Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
K252a C27H21N3O5 467.5 CaMKII Cools J. (2004) Cancer Res. 64 6385 Chin L.S. (1999) Cancer Invest. 17 391 WO2011114220 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
0.1µM
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 0 1
ERK1 8 1
ERK2 3 1
JNK1 3 1
JNK2 5 0
JNK3 3 0
p38 alpha MAPK 91 6
p38 beta MAPK 42 0
p38 gamma MAPK 8 0
p38 delta MAPK 41 1
ERK8 1 0
RSK1 1 1
RSK2 1 0
PDK1 3 3
PKB alpha 19 2
PKB beta 37 12
SGK1 8 1
S6K1 9 0
PKA 3 0
ROCK 2 12 2
PRK2 6 1
PKC alpha 5 1
PKC zeta 17 4
PKD1 15 2
MSK1 4 0
MNK1 41 5
MNK2 8 4
MAPKAP-K2 2 1
MAPKAP-K3 49 1
PRAK 14 2
CAMKK beta 18 4
CAMK1 15 6
SmMLCK 4 1
PHK 1 0
DAPK1 6 2
CHK1 9 2
CHK2 4 0
GSK3 beta 15 0
CDK2-Cyclin A 1 0
PLK1 41 1
Aurora A 0 0
Aurora B 5 2
LKB1 11 1
AMPK 4 2
MARK1 6 1
MARK2 24 9
MARK3 5 1
MARK4 7 1
BRSK1 11 2
BRSK2 3 0
MELK 5 3
NUAK1 7 0
CK1 delta 90 5
CK2 81 9
DYRK1A 1 1
DYRK2 1 0
DYRK3 1 0
NEK2a 48 3
NEK6 96 2
IKK beta 9 0
IKK epsilon 2 1
TBK1 3 1
PIM1 2 0
PIM2 12 1
PIM3 5 1
SRPK1 54 4
EF2K 100 5
HIPK1 34 4
HIPK2 4 1
HIPK3 24 0
CLK2 2 0
PAK2 11 2
PAK4 6 1
PAK5 5 0
PAK6 8 1
MST2 2 0
MST4 9 1
GCK 4 2
MINK1 3 1
MEKK1 2 1
MLK1 43 52
MLK3 3 0
TAK1 4 1
IRAK4 2 1
RIPK2 4 0
TTK 18 2
Src 6 1
Lck 6 3
CSK 22 2
YES1 10 0
BTK 4 1
JAK2 1 1
SYK 5 3
EPH-A2 29 6
EPH-A4 19 1
EPH-B2 44 3
EPH-B3 16 0
EPH-B4 75 13
FGF-R1 6 0
HER4 14 3
IGF-1R 3 1
IR 5 0
IRR 19 2
TrkA 6 1
VEGFR1 6 1
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 1 0
ERK1 24 3
ERK2 44 6
JNK1 65 12
JNK2 59 2
p38 alpha MAPK 86 10
p38 beta MAPK 110 22
p38 gamma MAPK 60 7
p38 delta MAPK 86 2
ERK8 3 0
RSK1 6 0
RSK2 28 8
PDK1 7 2
PKB alpha 82 4
PKB beta 78 3
SGK1 14 0
S6K1 28 2
PKA 51 7
ROCK 2 68 6
PRK2 7 0
PKC alpha 86 2
PKC zeta 77 17
PKD1 4 3
MSK1 28 7
MNK1 28 1
MNK2 6 0
MAPKAP-K2 4 1
PRAK 85 6
CAMKK beta 57 1
CAMK1 46 10
SmMLCK 32 2
PHK 0 0
CHK1 1 0
CHK2 14 20
GSK3 beta 66 5
CDK2-Cyclin A 41 3
PLK1 72 8
AMPK 17 7
MARK3 8 0
BRSK2 9 0
MELK 5 1
CK1 delta 86 1
CK2 99 3
DYRK1A 26 0
DYRK2 26 4
DYRK3 7 1
NEK2a 99 7
NEK6 93 4
IKK beta 54 11
IKK epsilon 19 0
TBK1 12 6
PIM1 18 0
PIM2 51 11
PIM3 3 0
SRPK1 92 2
EF2K 102 10
HIPK2 59 6
PAK4 21 0
PAK5 29 0
PAK6 30 2
MST2 4 2
MST4 244 41
Src 53 3
Lck 43 1
CSK 84 10
YES1 49 9
BTK 8 2
SYK 12 0
EPH-A2 97 9
EPH-B3 112 8
FGF-R1 50 0
IGF-1R 49 8
IR 94 6
IRR 29 1
VEGFR1 8 1
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 1 0
MKK2 5 1
MKK6 32 6
ERK1 14 5
ERK2 2 1
JNK1 1 0
JNK2 2 0
JNK3 5 0
p38 alpha MAPK 49 6
p38 beta MAPK 24 2
p38 gamma MAPK 7 3
p38 delta MAPK 11 0
ERK8 9 1
RSK1 3 0
RSK2 1 1
PDK1 5 0
PKB alpha 5 1
PKB beta 18 0
SGK1 8 3
S6K1 3 0
PKA 2 0
ROCK 2 21 6
PRK2 4 0
PKC alpha 18 4
PKC gamma 28 3
PKC zeta 3 1
PKD1 8 5
STK33 6 0
MSK1 1 0
MNK1 42 1
MNK2 39 2
MAPKAP-K2 0 0
MAPKAP-K3 11 3
PRAK 7 1
CAMKK beta 5 1
CAMK1 3 1
SmMLCK 12 2
PHK 5 2
DAPK1 8 0
CHK1 7 0
CHK2 5 8
GSK3 beta 2 1
CDK2-Cyclin A 6 1
PLK1 31 6
Aurora A 0 0
Aurora B 35 3
TLK1 3 2
LKB1 11 1
AMPK 14 1
MARK1 16 1
MARK2 20 14
MARK3 1 0
MARK4 9 0
BRSK1 5 3
BRSK2 3 1
MELK 9 4
NUAK1 2 0
CK1 delta 63 23
CK2 72 1
DYRK1A 0 0
DYRK2 5 6
DYRK3 4 1
NEK2a 20 5
NEK6 85 0
IKK beta 4 1
IKK epsilon 2 0
TBK1 11 9
PIM1 5 0
PIM2 2 0
PIM3 2 0
SRPK1 16 1
EF2K 105 1
EIF2AK3 15 1
HIPK1 7 0
HIPK2 2 0
HIPK3 4 0
CLK2 3 0
PAK2 4 0
PAK4 3 1
PAK5 4 1
PAK6 1 0
MST2 14 4
MST4 14 1
GCK 3 0
MINK1 24 1
MEKK1 54 5
MLK1 15 3
MLK3 11 0
TAO1 5 1
ASK1 6 0
TAK1 3 3
IRAK1 2 1
IRAK4 3 1
RIPK2 14 4
OSR1 4 0
TTK 19 1
MPSK1 12 1
Src 4 1
Lck 10 2
CSK 28 7
YES1 6 3
ABL 32 2
BTK 19 4
JAK2 3 3
SYK 5 1
ZAP70 6 1
TIE2 7 1
BRK 4 3
EPH-A2 8 1
EPH-A4 7 0
EPH-B1 19 1
EPH-B2 8 1
EPH-B3 49 0
EPH-B4 22 1
FGF-R1 3 1
HER4 13 0
IGF-1R 0 0
IR 1 0
IRR 2 1
TrkA 2 1
VEGFR1 2 1

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