Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
IRAK-4 kinase inhibitor a C22H24N4O6 440.45 IRAK4 Wang Z. (2006) Structure 14 1835-1844 Download

Results as Barchart

View results as a bar chart
1µM
10µM
0.1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
IRAK4 2 1
CLK2 6 2
CK1 delta 10 1
MINK1 14 3
TAK1 17 4
TrkA 27 3
DYRK1A 28 4
MLK3 30 4
GCK 32 2
VEGFR1 35 7
PHK 35 1
CAMKK beta 44 1
SRPK1 44 3
DYRK3 44 2
MLK1 47 0
IRR 47 0
TTK 55 8
GSK3 beta 59 4
Aurora B 60 1
MEKK1 61 3
NUAK1 62 9
RSK1 66 1
PAK4 66 3
SmMLCK 69 2
PIM1 69 1
MARK4 69 2
DYRK2 70 2
MST4 71 0
BTK 71 6
PIM3 73 2
MSK1 73 3
RSK2 73 5
PKB beta 74 10
MARK2 74 3
PIM2 74 3
CHK1 75 2
NEK2a 76 9
Lck 76 2
MARK1 77 1
JNK3 77 0
NEK6 77 1
CHK2 78 6
MKK1 79 3
AMPK 79 8
DAPK1 79 6
BRSK2 80 3
MELK 80 9
S6K1 81 6
BRSK1 81 1
p38 beta MAPK 81 9
Aurora A 81 2
FGF-R1 81 1
MKK2 83 8
p38 alpha MAPK 83 5
HIPK2 83 1
MAPKAP-K3 83 5
MARK3 84 4
ERK8 84 8
ROCK 2 85 14
TAO1 85 3
p38 gamma MAPK 85 5
EPH-B3 86 9
PDK1 86 4
MST2 87 2
TBK1 87 13
PAK5 87 1
PAK6 87 5
CSK 87 4
MKK6 88 5
RIPK2 88 1
PRAK 88 6
JAK2 89 1
ERK1 89 3
IKK epsilon 90 2
CAMK1 92 11
SGK1 92 5
PRK2 92 2
EPH-B2 92 11
PLK1 92 3
PKB alpha 93 4
ERK2 93 11
PKA 93 1
p38 delta MAPK 93 11
PKC alpha 94 8
HIPK1 94 6
CK2 94 12
LKB1 94 7
YES1 96 6
SYK 96 1
JNK2 96 1
PKD1 96 3
EPH-A4 97 2
CDK2-Cyclin A 97 7
MNK1 97 10
PKC zeta 98 15
HIPK3 98 2
Src 98 5
MAPKAP-K2 99 8
EF2K 101 7
ASK1 101 11
JNK1 103 2
IGF-1R 103 3
IR 103 4
MNK2 104 3
EPH-B1 106 7
HER4 106 12
EPH-A2 109 6
IKK beta 111 6
EPH-B4 112 5
PAK2 121 14
Screening Concentration: 0.1µM
Kinase % Activity Remainingsort descending Standard Deviation
IRAK4 6 4
IRAK1 15 2
CLK2 49 2
TAK1 55 15
CK2 65 7
MINK1 66 0
MKK2 67 17
IRR 68 0
ERK8 69 1
Aurora B 70 16
PKD1 76 13
HIPK3 77 7
EF2K 78 13
CK1 delta 78 6
STK33 82 3
MKK1 83 23
NEK6 83 9
EPH-B3 84 6
MARK4 84 9
TBK1 84 6
GSK3 beta 84 6
NEK2a 85 11
GCK 85 12
NUAK1 85 4
LKB1 86 4
JNK2 86 3
CSK 86 6
p38 delta MAPK 86 15
PAK2 87 11
MAPKAP-K3 87 7
MARK2 87 8
TTK 87 12
MPSK1 87 19
DAPK1 87 7
PIM2 87 0
MLK3 87 5
JAK2 87 9
MST2 88 14
IGF-1R 88 16
PAK5 89 6
SGK1 89 8
p38 alpha MAPK 89 22
SYK 89 23
MARK1 90 8
CAMKK beta 90 0
ERK1 90 7
CHK1 90 15
YES1 90 2
p38 gamma MAPK 90 5
TIE2 90 5
AMPK 91 8
MARK3 91 2
PKA 91 9
EPH-B4 91 3
BRSK1 91 13
IR 91 0
TrkA 91 15
HIPK2 91 22
ASK1 91 9
DYRK1A 91 4
ROCK 2 92 12
PIM3 92 1
CDK2-Cyclin A 92 6
PDK1 93 7
EPH-A2 93 4
RIPK2 93 21
S6K1 93 35
MELK 93 3
CHK2 93 5
SRPK1 93 9
MLK1 93 5
HIPK1 93 8
VEGFR1 93 1
MNK1 93 7
MNK2 93 4
PAK4 94 10
IKK epsilon 94 10
PHK 94 7
EIF2AK3 94 0
PLK1 94 0
RSK1 94 3
DYRK3 95 3
PKB beta 95 13
Lck 95 19
PRK2 95 7
JNK3 95 6
p38 beta MAPK 95 15
BRK 95 19
EPH-A4 96 4
IKK beta 96 4
ERK2 96 18
MEKK1 96 0
TSSK1 96 10
TTBK1 96 11
RSK2 96 5
TLK1 96 10
DYRK2 96 7
MST4 97 20
JNK1 97 2
PIM1 97 10
BTK 97 9
TESK1 97 9
SmMLCK 98 1
BRSK2 98 5
HER4 99 5
TAO1 99 9
ZAP70 99 2
OSR1 100 8
MSK1 100 17
Aurora A 101 8
PKB alpha 102 7
ABL 102 7
MAPKAP-K2 104 6
PKC gamma 105 0
PKC alpha 106 18
PAK6 107 3
FGF-R1 108 1
PRAK 110 18
EPH-B1 111 13
Src 111 21
PKC zeta 114 16
EPH-B2 117 9
CAMK1 118 20
MKK6 126 9
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
IRAK4 6 0
IRAK1 11 3
MINK1 30 2
CLK2 50 13
DYRK1A 54 2
PHK 62 6
IRR 69 10
TAK1 71 11
CK1 delta 72 2
MKK2 77 15
PKB beta 79 2
Aurora B 80 4
RSK2 80 20
SmMLCK 81 20
MLK3 81 5
CK2 81 12
PKD1 82 1
ERK8 83 21
VEGFR1 83 9
STK33 84 4
DYRK3 86 1
MARK4 86 5
NUAK1 86 18
TTBK1 87 14
HIPK2 87 11
IKK beta 87 0
DAPK1 87 9
CSK 88 7
IGF-1R 88 2
BRSK2 89 9
CDK2-Cyclin A 89 7
ASK1 90 7
HIPK3 90 16
NEK2a 90 0
PIM2 90 1
SRPK1 90 13
MAPKAP-K3 91 1
PAK4 91 0
SGK1 91 2
TTK 91 8
MPSK1 91 17
IR 91 5
JAK2 91 3
NEK6 92 15
MKK1 92 1
GCK 92 13
Lck 92 11
LKB1 93 9
EPH-A2 93 7
MARK3 93 10
Src 93 15
JNK2 93 4
PAK5 94 11
OSR1 94 10
PKA 94 5
EF2K 94 4
BTK 94 16
p38 alpha MAPK 94 2
MARK2 95 14
CHK1 95 2
GSK3 beta 95 6
JNK3 95 7
RIPK2 96 13
SYK 97 18
TBK1 97 9
ROCK 2 97 7
RSK1 98 11
PAK2 98 7
CAMKK beta 98 1
ERK1 98 11
MELK 98 5
PIM3 98 6
MSK1 99 5
EPH-B3 99 25
MLK1 99 5
EIF2AK3 99 9
TrkA 99 14
TAO1 100 26
MARK1 100 3
S6K1 100 5
HER4 100 15
p38 delta MAPK 100 8
Aurora A 101 16
AMPK 101 17
PIM1 101 6
MEKK1 101 13
MST2 102 7
EPH-B4 102 4
CHK2 102 12
PDK1 103 13
PRAK 103 9
EPH-A4 103 1
JNK1 103 2
p38 beta MAPK 103 2
ZAP70 104 22
MNK2 104 2
PAK6 104 13
PRK2 104 14
ERK2 104 8
PKC gamma 104 7
ABL 105 8
TLK1 106 11
DYRK2 106 17
BRSK1 106 14
TSSK1 106 21
HIPK1 106 24
MNK1 107 0
BRK 107 0
PKC zeta 107 3
p38 gamma MAPK 107 18
PLK1 107 5
TIE2 108 9
PKB alpha 108 3
MST4 109 10
EPH-B2 110 7
TESK1 110 8
FGF-R1 111 16
IKK epsilon 113 11
EPH-B1 118 3
PKC alpha 119 6
MAPKAP-K2 121 6
YES1 122 4
CAMK1 134 7
MKK6 138 63

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