Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
IRAK-4 kinase inhibitor a C22H24N4O6 440.45 IRAK4 Wang Z. (2006) Structure 14 1835-1844 Download

Results as Barchart

View results as a bar chart
1µM
10µM
0.1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 92 1
MKK2 77 15
MKK6 138 63
ERK1 98 11
ERK2 104 8
JNK1 103 2
JNK2 93 4
JNK3 95 7
p38 alpha MAPK 94 2
p38 beta MAPK 103 2
p38 gamma MAPK 107 18
p38 delta MAPK 100 8
ERK8 83 21
RSK1 98 11
RSK2 80 20
PDK1 103 13
PKB alpha 108 3
PKB beta 79 2
SGK1 91 2
S6K1 100 5
PKA 94 5
ROCK 2 97 7
PRK2 104 14
PKC alpha 119 6
PKC gamma 104 7
PKC zeta 107 3
PKD1 82 1
STK33 84 4
MSK1 99 5
MNK1 107 0
MNK2 104 2
MAPKAP-K2 121 6
MAPKAP-K3 91 1
PRAK 103 9
CAMKK beta 98 1
CAMK1 134 7
SmMLCK 81 20
PHK 62 6
DAPK1 87 9
CHK1 95 2
CHK2 102 12
GSK3 beta 95 6
CDK2-Cyclin A 89 7
PLK1 107 5
Aurora A 101 16
Aurora B 80 4
TLK1 106 11
LKB1 93 9
AMPK 101 17
MARK1 100 3
MARK2 95 14
MARK3 93 10
MARK4 86 5
BRSK1 106 14
BRSK2 89 9
MELK 98 5
NUAK1 86 18
TSSK1 106 21
CK1 delta 72 2
CK2 81 12
TTBK1 87 14
DYRK1A 54 2
DYRK2 106 17
DYRK3 86 1
NEK2a 90 0
NEK6 92 15
IKK beta 87 0
IKK epsilon 113 11
TBK1 97 9
PIM1 101 6
PIM2 90 1
PIM3 98 6
SRPK1 90 13
EF2K 94 4
EIF2AK3 99 9
HIPK1 106 24
HIPK2 87 11
HIPK3 90 16
CLK2 50 13
PAK2 98 7
PAK4 91 0
PAK5 94 11
PAK6 104 13
MST2 102 7
MST4 109 10
GCK 92 13
MINK1 30 2
MEKK1 101 13
MLK1 99 5
MLK3 81 5
TESK1 110 8
TAO1 100 26
ASK1 90 7
TAK1 71 11
IRAK1 11 3
IRAK4 6 0
RIPK2 96 13
OSR1 94 10
TTK 91 8
MPSK1 91 17
Src 93 15
Lck 92 11
CSK 88 7
YES1 122 4
ABL 105 8
BTK 94 16
JAK2 91 3
SYK 97 18
ZAP70 104 22
TIE2 108 9
BRK 107 0
EPH-A2 93 7
EPH-A4 103 1
EPH-B1 118 3
EPH-B2 110 7
EPH-B3 99 25
EPH-B4 102 4
FGF-R1 111 16
HER4 100 15
IGF-1R 88 2
IR 91 5
IRR 69 10
TrkA 99 14
VEGFR1 83 9
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 79 3
MKK2 83 8
MKK6 88 5
ERK1 89 3
ERK2 93 11
JNK1 103 2
JNK2 96 1
JNK3 77 0
p38 alpha MAPK 83 5
p38 beta MAPK 81 9
p38 gamma MAPK 85 5
p38 delta MAPK 93 11
ERK8 84 8
RSK1 66 1
RSK2 73 5
PDK1 86 4
PKB alpha 93 4
PKB beta 74 10
SGK1 92 5
S6K1 81 6
PKA 93 1
ROCK 2 85 14
PRK2 92 2
PKC alpha 94 8
PKC zeta 98 15
PKD1 96 3
MSK1 73 3
MNK1 97 10
MNK2 104 3
MAPKAP-K2 99 8
MAPKAP-K3 83 5
PRAK 88 6
CAMKK beta 44 1
CAMK1 92 11
SmMLCK 69 2
PHK 35 1
DAPK1 79 6
CHK1 75 2
CHK2 78 6
GSK3 beta 59 4
CDK2-Cyclin A 97 7
PLK1 92 3
Aurora A 81 2
Aurora B 60 1
LKB1 94 7
AMPK 79 8
MARK1 77 1
MARK2 74 3
MARK3 84 4
MARK4 69 2
BRSK1 81 1
BRSK2 80 3
MELK 80 9
NUAK1 62 9
CK1 delta 10 1
CK2 94 12
DYRK1A 28 4
DYRK2 70 2
DYRK3 44 2
NEK2a 76 9
NEK6 77 1
IKK beta 111 6
IKK epsilon 90 2
TBK1 87 13
PIM1 69 1
PIM2 74 3
PIM3 73 2
SRPK1 44 3
EF2K 101 7
HIPK1 94 6
HIPK2 83 1
HIPK3 98 2
CLK2 6 2
PAK2 121 14
PAK4 66 3
PAK5 87 1
PAK6 87 5
MST2 87 2
MST4 71 0
GCK 32 2
MINK1 14 3
MEKK1 61 3
MLK1 47 0
MLK3 30 4
TAO1 85 3
ASK1 101 11
TAK1 17 4
IRAK4 2 1
RIPK2 88 1
TTK 55 8
Src 98 5
Lck 76 2
CSK 87 4
YES1 96 6
BTK 71 6
JAK2 89 1
SYK 96 1
EPH-A2 109 6
EPH-A4 97 2
EPH-B1 106 7
EPH-B2 92 11
EPH-B3 86 9
EPH-B4 112 5
FGF-R1 81 1
HER4 106 12
IGF-1R 103 3
IR 103 4
IRR 47 0
TrkA 27 3
VEGFR1 35 7
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 83 23
MKK2 67 17
MKK6 126 9
ERK1 90 7
ERK2 96 18
JNK1 97 2
JNK2 86 3
JNK3 95 6
p38 alpha MAPK 89 22
p38 beta MAPK 95 15
p38 gamma MAPK 90 5
p38 delta MAPK 86 15
ERK8 69 1
RSK1 94 3
RSK2 96 5
PDK1 93 7
PKB alpha 102 7
PKB beta 95 13
SGK1 89 8
S6K1 93 35
PKA 91 9
ROCK 2 92 12
PRK2 95 7
PKC alpha 106 18
PKC gamma 105 0
PKC zeta 114 16
PKD1 76 13
STK33 82 3
MSK1 100 17
MNK1 93 7
MNK2 93 4
MAPKAP-K2 104 6
MAPKAP-K3 87 7
PRAK 110 18
CAMKK beta 90 0
CAMK1 118 20
SmMLCK 98 1
PHK 94 7
DAPK1 87 7
CHK1 90 15
CHK2 93 5
GSK3 beta 84 6
CDK2-Cyclin A 92 6
PLK1 94 0
Aurora A 101 8
Aurora B 70 16
TLK1 96 10
LKB1 86 4
AMPK 91 8
MARK1 90 8
MARK2 87 8
MARK3 91 2
MARK4 84 9
BRSK1 91 13
BRSK2 98 5
MELK 93 3
NUAK1 85 4
TSSK1 96 10
CK1 delta 78 6
CK2 65 7
TTBK1 96 11
DYRK1A 91 4
DYRK2 96 7
DYRK3 95 3
NEK2a 85 11
NEK6 83 9
IKK beta 96 4
IKK epsilon 94 10
TBK1 84 6
PIM1 97 10
PIM2 87 0
PIM3 92 1
SRPK1 93 9
EF2K 78 13
EIF2AK3 94 0
HIPK1 93 8
HIPK2 91 22
HIPK3 77 7
CLK2 49 2
PAK2 87 11
PAK4 94 10
PAK5 89 6
PAK6 107 3
MST2 88 14
MST4 97 20
GCK 85 12
MINK1 66 0
MEKK1 96 0
MLK1 93 5
MLK3 87 5
TESK1 97 9
TAO1 99 9
ASK1 91 9
TAK1 55 15
IRAK1 15 2
IRAK4 6 4
RIPK2 93 21
OSR1 100 8
TTK 87 12
MPSK1 87 19
Src 111 21
Lck 95 19
CSK 86 6
YES1 90 2
ABL 102 7
BTK 97 9
JAK2 87 9
SYK 89 23
ZAP70 99 2
TIE2 90 5
BRK 95 19
EPH-A2 93 4
EPH-A4 96 4
EPH-B1 111 13
EPH-B2 117 9
EPH-B3 84 6
EPH-B4 91 3
FGF-R1 108 1
HER4 99 5
IGF-1R 88 16
IR 91 0
IRR 68 0
TrkA 91 15
VEGFR1 93 1

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