Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
IKK-3 inhibitor IX C22H19N3O5S2 469.5 IKK3 Bamborough P. (2006) Bioorg. Med. Chem. Lett. 16 6236 US20120134931 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 75 10
MKK2 57 9
MKK6 84 4
ERK1 77 10
ERK2 88 4
JNK1 87 1
JNK2 90 4
JNK3 77 6
p38 alpha MAPK 85 3
p38 beta MAPK 83 0
p38 gamma MAPK 94 3
p38 delta MAPK 86 14
ERK8 15 4
RSK1 28 6
RSK2 57 9
PDK1 52 10
PKB alpha 85 10
PKB beta 98 2
SGK1 88 2
S6K1 66 7
PKA 83 6
ROCK 2 61 8
PRK2 64 8
PKC alpha 88 1
PKC zeta 95 4
PKD1 92 3
MSK1 58 3
MNK1 34 0
MNK2 35 1
MAPKAP-K2 85 4
MAPKAP-K3 67 1
PRAK 87 1
CAMKK beta 86 4
CAMK1 80 1
SmMLCK 61 1
PHK 4 0
DAPK1 51 1
CHK1 64 6
CHK2 19 3
GSK3 beta 68 2
CDK2-Cyclin A 99 1
PLK1 55 2
Aurora A 6 0
Aurora B 4 1
LKB1 62 5
AMPK 9 3
MARK1 31 2
MARK2 35 4
MARK3 41 2
MARK4 42 1
BRSK1 34 5
BRSK2 30 4
MELK 59 7
NUAK1 35 2
CK1 delta 91 0
CK2 107 11
DYRK1A 81 3
DYRK2 72 3
DYRK3 82 12
NEK2a 39 3
NEK6 77 1
IKK beta 78 11
IKK epsilon 6 1
TBK1 17 3
PIM1 71 6
PIM2 78 10
PIM3 73 0
SRPK1 79 9
EF2K 98 5
HIPK1 58 1
HIPK2 32 7
HIPK3 61 1
CLK2 18 0
PAK2 111 3
PAK4 41 3
PAK5 58 6
PAK6 67 0
MST2 7 1
MST4 47 5
GCK 8 0
MINK1 1 0
MEKK1 54 12
MLK1 8 1
MLK3 3 2
TAO1 27 1
ASK1 69 1
TAK1 70 6
IRAK4 6 2
RIPK2 6 0
TTK 77 5
Src 64 1
Lck 33 2
CSK 74 3
YES1 58 0
BTK 45 13
JAK2 18 1
SYK 87 9
EPH-A2 53 9
EPH-A4 45 3
EPH-B1 95 2
EPH-B2 50 5
EPH-B3 27 4
EPH-B4 82 12
FGF-R1 49 5
HER4 84 11
IGF-1R 92 3
IR 105 8
IRR 66 4
TrkA 28 4
VEGFR1 23 2
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 78 8
MKK2 75 0
MKK6 91 6
ERK1 101 12
ERK2 104 12
JNK1 92 1
JNK2 95 7
JNK3 99 5
p38 alpha MAPK 91 1
p38 beta MAPK 103 3
p38 gamma MAPK 93 9
p38 delta MAPK 112 14
ERK8 65 7
RSK1 50 5
RSK2 82 2
PDK1 71 11
PKB alpha 98 0
PKB beta 72 2
SGK1 105 4
S6K1 87 0
PKA 101 0
ROCK 2 93 11
PRK2 63 0
PKC alpha 96 4
PKC zeta 97 0
PKD1 93 5
MSK1 78 4
MNK1 47 0
MNK2 47 8
MAPKAP-K2 99 5
MAPKAP-K3 93 2
PRAK 101 7
CAMKK beta 112 1
CAMK1 90 12
SmMLCK 89 2
PHK 5 0
DAPK1 54 6
CHK1 79 8
CHK2 19 3
GSK3 beta 90 7
CDK2-Cyclin A 100 10
PLK1 65 2
Aurora A 29 0
Aurora B 6 1
LKB1 80 3
AMPK 10 1
MARK1 33 5
MARK2 39 1
MARK3 31 1
MARK4 57 9
BRSK1 40 1
BRSK2 31 0
MELK 84 8
NUAK1 35 5
CK1 delta 89 7
CK2 118 5
DYRK1A 73 6
DYRK2 84 8
DYRK3 75 3
NEK2a 41 1
NEK6 93 4
IKK beta 103 8
IKK epsilon 9 2
TBK1 21 3
PIM1 94 1
PIM2 93 3
PIM3 90 5
SRPK1 93 2
EF2K 105 1
HIPK1 99 1
HIPK2 49 3
HIPK3 102 5
CLK2 47 0
PAK2 94 6
PAK4 53 6
PAK5 80 1
PAK6 95 1
MST2 19 1
MST4 76 4
GCK 24 2
MINK1 5 1
MEKK1 77 5
MLK1 28 1
MLK3 5 1
TAO1 61 3
ASK1 83 2
TAK1 100 8
IRAK4 13 1
RIPK2 14 3
TTK 83 1
Src 57 4
Lck 35 10
CSK 81 7
YES1 43 2
BTK 63 6
JAK2 34 7
SYK 95 12
EPH-A2 66 4
EPH-A4 57 5
EPH-B1 79 8
EPH-B2 62 6
EPH-B3 40 3
EPH-B4 94 4
FGF-R1 49 2
HER4 78 2
IGF-1R 89 6
IR 104 4
IRR 77 11
TrkA 30 1
VEGFR1 15 2

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