Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
IKK-2 Inhibitor IV (TPCA-1) C12H10FN3O2S 279.3 IKK2 Podolin P.L. (2005) J. Pharmacol. Exp. Ther. 312 373 Karin M. (2004) Nat. Rev. Drug Discov. 3 17 WO2008144011 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 74 1
MKK2 54 0
MKK6 89 8
ERK1 107 10
ERK2 102 11
JNK1 93 8
JNK2 106 4
JNK3 93 2
p38 alpha MAPK 101 9
p38 beta MAPK 96 4
p38 gamma MAPK 92 4
p38 delta MAPK 122 11
ERK8 83 2
RSK1 77 3
RSK2 76 5
PDK1 87 0
PKB alpha 97 7
PKB beta 90 15
SGK1 108 6
S6K1 102 1
PKA 98 3
ROCK 2 80 3
PRK2 71 4
PKC alpha 81 1
PKC zeta 102 3
PKD1 86 5
MSK1 97 0
MNK1 100 3
MNK2 105 5
MAPKAP-K2 98 9
MAPKAP-K3 94 10
PRAK 100 7
CAMKK beta 66 2
CAMK1 82 2
SmMLCK 104 7
PHK 90 3
DAPK1 62 3
CHK1 83 1
CHK2 51 8
GSK3 beta 87 1
CDK2-Cyclin A 35 5
PLK1 91 0
Aurora A 54 8
Aurora B 21 2
LKB1 71 0
AMPK 83 7
MARK1 98 10
MARK2 76 10
MARK3 81 2
MARK4 91 7
BRSK1 77 10
BRSK2 98 6
MELK 89 2
NUAK1 31 1
CK1 delta 97 1
CK2 109 8
DYRK1A 97 1
DYRK2 100 8
DYRK3 101 4
NEK2a 94 8
NEK6 108 3
IKK beta 15 0
IKK epsilon 86 3
TBK1 75 0
PIM1 85 4
PIM2 104 8
PIM3 78 6
SRPK1 92 8
EF2K 103 6
HIPK1 109 0
HIPK2 101 5
HIPK3 100 12
CLK2 84 5
PAK2 97 13
PAK4 74 2
PAK5 88 8
PAK6 90 0
MST2 50 7
MST4 79 0
GCK 48 1
MINK1 69 12
MEKK1 61 6
MLK1 21 0
MLK3 19 0
TAO1 71 4
ASK1 62 1
TAK1 21 0
IRAK4 61 0
RIPK2 90 4
TTK 94 3
Src 39 2
Lck 80 2
CSK 101 12
YES1 57 11
BTK 26 1
JAK2 11 1
SYK 91 3
EPH-A2 59 11
EPH-A4 73 10
EPH-B1 68 6
EPH-B2 83 10
EPH-B3 37 2
EPH-B4 85 8
FGF-R1 61 3
HER4 70 11
IGF-1R 64 14
IR 94 14
IRR 96 7
TrkA 32 1
VEGFR1 23 0
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 23 2
MKK2 13 1
MKK6 62 7
ERK1 62 5
ERK2 68 9
JNK1 83 4
JNK2 83 1
JNK3 65 1
p38 alpha MAPK 81 3
p38 beta MAPK 65 8
p38 gamma MAPK 59 13
p38 delta MAPK 85 7
ERK8 25 1
RSK1 23 4
RSK2 36 1
PDK1 34 3
PKB alpha 85 4
PKB beta 60 10
SGK1 91 2
S6K1 81 4
PKA 85 6
ROCK 2 56 4
PRK2 41 7
PKC alpha 44 3
PKC zeta 94 12
PKD1 46 0
MSK1 80 4
MNK1 56 11
MNK2 58 3
MAPKAP-K2 85 1
MAPKAP-K3 74 1
PRAK 77 1
CAMKK beta 77 2
CAMK1 35 9
SmMLCK 42 3
PHK 31 2
DAPK1 21 0
CHK1 39 2
CHK2 17 10
GSK3 beta 47 2
CDK2-Cyclin A 8 2
PLK1 77 2
Aurora A 11 1
Aurora B 5 1
LKB1 32 0
AMPK 26 1
MARK1 44 3
MARK2 52 12
MARK3 45 1
MARK4 57 6
BRSK1 27 2
BRSK2 42 4
MELK 45 1
NUAK1 8 1
CK1 delta 81 7
CK2 67 0
DYRK1A 65 5
DYRK2 50 3
DYRK3 73 2
NEK2a 65 2
NEK6 98 8
IKK beta 8 0
IKK epsilon 30 1
TBK1 38 8
PIM1 40 5
PIM2 37 1
PIM3 38 2
SRPK1 76 4
EF2K 54 8
HIPK1 87 7
HIPK2 49 15
HIPK3 81 6
CLK2 35 1
PAK2 72 5
PAK4 33 2
PAK5 40 8
PAK6 49 4
MST2 12 0
MST4 19 2
GCK 8 0
MINK1 13 1
MEKK1 17 4
MLK1 4 1
MLK3 2 0
TAO1 21 2
ASK1 14 1
TAK1 5 2
IRAK4 13 1
RIPK2 29 1
TTK 64 4
Src 14 3
Lck 36 3
CSK 90 9
YES1 15 1
BTK 10 0
JAK2 9 3
SYK 38 2
EPH-A2 31 0
EPH-A4 21 1
EPH-B1 17 1
EPH-B2 18 1
EPH-B3 12 5
EPH-B4 34 1
FGF-R1 17 1
HER4 22 2
IGF-1R 9 2
IR 46 5
IRR 57 6
TrkA 26 3
VEGFR1 4 0

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