Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
HA-1077, Dihydrochloride (Fasudil) C14H17N3O2S • 2HCl 364.3 PKA Watanabe K. (2007) Nature Biotechnology 25 681 Swärd K. (2000) J. Physiol. 522 33 WO1999041984 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
ROCK 2 12 3
ERK8 14 1
RSK1 16 0
PRK2 17 2
MSK1 20 2
PKA 26 2
NUAK1 27 2
S6K1 33 7
DYRK3 36 4
PKD1 44 2
RSK2 44 1
CHK2 47 3
TAK1 47 6
CLK2 51 2
MNK1 52 6
MELK 54 6
MNK2 55 2
PKB alpha 55 1
BRSK1 55 2
DAPK1 55 5
MEKK1 57 5
BRSK2 58 2
VEGFR1 60 6
PHK 61 2
LKB1 62 1
MKK2 63 2
SmMLCK 64 2
MLK3 65 6
FGF-R1 66 2
MST2 69 5
Aurora B 70 2
MKK1 72 1
AMPK 73 6
GCK 74 2
MAPKAP-K2 75 6
MINK1 77 8
PKC alpha 77 2
CAMKK beta 79 9
GSK3 beta 80 4
MLK1 81 2
JNK3 81 2
IRAK4 82 2
PAK5 83 13
JAK2 83 0
MARK3 83 1
EPH-B3 83 6
DYRK2 84 6
p38 delta MAPK 84 9
ERK2 84 15
CK1 delta 84 1
p38 alpha MAPK 84 8
PIM3 85 7
TAO1 85 5
PKC zeta 85 10
MAPKAP-K3 87 6
MARK1 87 3
TTK 88 0
PAK6 88 3
SYK 88 7
DYRK1A 88 2
PIM1 89 2
PKB beta 89 5
SGK1 89 1
HIPK3 89 10
NEK2a 91 7
TBK1 91 1
CAMK1 91 3
MKK6 91 5
CHK1 91 6
Aurora A 92 7
IRR 92 1
IKK epsilon 92 2
ERK1 92 1
PAK4 93 3
Src 93 0
PDK1 93 2
MARK2 93 4
ASK1 93 11
RIPK2 93 6
HER4 93 9
IKK beta 94 13
YES1 94 1
BTK 94 0
EPH-A2 94 6
JNK1 94 0
EF2K 95 4
MST4 96 4
MARK4 96 3
EPH-B1 96 6
HIPK1 96 5
EPH-B4 96 7
Lck 97 5
CSK 97 1
EPH-B2 97 5
PRAK 98 12
PAK2 99 2
HIPK2 99 4
NEK6 100 3
EPH-A4 100 4
PLK1 101 2
PIM2 101 1
SRPK1 103 0
p38 gamma MAPK 104 8
IR 104 2
JNK2 104 8
CDK2-Cyclin A 104 1
CK2 105 1
IGF-1R 107 1
p38 beta MAPK 111 6
TrkA 118 15
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
ROCK 2 32 0
RSK1 52 6
ERK8 59 5
PRK2 62 3
MSK1 65 6
NUAK1 71 1
PKA 79 3
NEK2a 81 3
BRSK1 81 8
S6K1 81 1
DAPK1 81 1
PAK4 84 8
MLK3 84 1
p38 beta MAPK 86 5
PKD1 87 3
TAK1 88 5
GSK3 beta 90 3
DYRK3 90 3
JAK2 90 2
LKB1 91 12
RSK2 92 1
MST4 92 3
MKK1 92 9
JNK1 93 6
PIM3 94 3
HIPK3 95 3
CLK2 95 1
MLK1 95 5
EPH-B3 95 11
BTK 96 3
CHK2 96 9
PKC zeta 97 0
HIPK1 97 6
p38 alpha MAPK 98 2
DYRK1A 98 0
PKB alpha 98 8
CAMKK beta 98 1
MEKK1 98 10
SmMLCK 98 11
IRAK4 99 4
CDK2-Cyclin A 99 6
TrkA 99 3
MARK2 99 3
MKK2 99 2
SGK1 99 4
TTK 100 5
PKB beta 100 1
PIM2 100 6
CK1 delta 100 5
Aurora B 101 0
MARK3 101 2
PHK 101 3
JNK2 101 8
RIPK2 102 8
PAK2 102 1
Src 102 2
NEK6 102 11
IKK beta 102 3
YES1 102 4
PDK1 102 7
HER4 103 10
EPH-B1 103 4
MNK1 104 10
PAK5 104 11
MST2 104 5
MARK4 104 7
EF2K 104 2
JNK3 105 0
TBK1 105 2
GCK 105 5
MINK1 105 9
BRSK2 105 2
MELK 105 1
FGF-R1 106 7
VEGFR1 106 1
PIM1 106 13
MKK6 106 9
PKC alpha 107 3
Aurora A 107 13
PAK6 107 1
CSK 107 11
PRAK 107 1
ERK1 107 0
p38 delta MAPK 108 4
EPH-B4 108 9
DYRK2 109 6
MNK2 109 15
IKK epsilon 109 11
CK2 110 6
IGF-1R 110 6
IRR 110 6
MAPKAP-K2 110 7
MAPKAP-K3 110 9
SRPK1 110 7
AMPK 111 0
EPH-A2 111 1
PLK1 112 9
HIPK2 113 1
ERK2 114 5
CAMK1 115 1
p38 gamma MAPK 116 1
CHK1 117 4
EPH-A4 119 1
TAO1 120 3
IR 121 5
SYK 121 4
MARK1 124 15
ASK1 124 0
Lck 127 8
EPH-B2 127 14

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