Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
HA-1077, Dihydrochloride (Fasudil) C14H17N3O2S • 2HCl 364.3 PKA Watanabe K. (2007) Nature Biotechnology 25 681 Swärd K. (2000) J. Physiol. 522 33 WO1999041984 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 72 1
MKK2 63 2
MKK6 91 5
ERK1 92 1
ERK2 84 15
JNK1 94 0
JNK2 104 8
JNK3 81 2
p38 alpha MAPK 84 8
p38 beta MAPK 111 6
p38 gamma MAPK 104 8
p38 delta MAPK 84 9
ERK8 14 1
RSK1 16 0
RSK2 44 1
PDK1 93 2
PKB alpha 55 1
PKB beta 89 5
SGK1 89 1
S6K1 33 7
PKA 26 2
ROCK 2 12 3
PRK2 17 2
PKC alpha 77 2
PKC zeta 85 10
PKD1 44 2
MSK1 20 2
MNK1 52 6
MNK2 55 2
MAPKAP-K2 75 6
MAPKAP-K3 87 6
PRAK 98 12
CAMKK beta 79 9
CAMK1 91 3
SmMLCK 64 2
PHK 61 2
DAPK1 55 5
CHK1 91 6
CHK2 47 3
GSK3 beta 80 4
CDK2-Cyclin A 104 1
PLK1 101 2
Aurora A 92 7
Aurora B 70 2
LKB1 62 1
AMPK 73 6
MARK1 87 3
MARK2 93 4
MARK3 83 1
MARK4 96 3
BRSK1 55 2
BRSK2 58 2
MELK 54 6
NUAK1 27 2
CK1 delta 84 1
CK2 105 1
DYRK1A 88 2
DYRK2 84 6
DYRK3 36 4
NEK2a 91 7
NEK6 100 3
IKK beta 94 13
IKK epsilon 92 2
TBK1 91 1
PIM1 89 2
PIM2 101 1
PIM3 85 7
SRPK1 103 0
EF2K 95 4
HIPK1 96 5
HIPK2 99 4
HIPK3 89 10
CLK2 51 2
PAK2 99 2
PAK4 93 3
PAK5 83 13
PAK6 88 3
MST2 69 5
MST4 96 4
GCK 74 2
MINK1 77 8
MEKK1 57 5
MLK1 81 2
MLK3 65 6
TAO1 85 5
ASK1 93 11
TAK1 47 6
IRAK4 82 2
RIPK2 93 6
TTK 88 0
Src 93 0
Lck 97 5
CSK 97 1
YES1 94 1
BTK 94 0
JAK2 83 0
SYK 88 7
EPH-A2 94 6
EPH-A4 100 4
EPH-B1 96 6
EPH-B2 97 5
EPH-B3 83 6
EPH-B4 96 7
FGF-R1 66 2
HER4 93 9
IGF-1R 107 1
IR 104 2
IRR 92 1
TrkA 118 15
VEGFR1 60 6
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 92 9
MKK2 99 2
MKK6 106 9
ERK1 107 0
ERK2 114 5
JNK1 93 6
JNK2 101 8
JNK3 105 0
p38 alpha MAPK 98 2
p38 beta MAPK 86 5
p38 gamma MAPK 116 1
p38 delta MAPK 108 4
ERK8 59 5
RSK1 52 6
RSK2 92 1
PDK1 102 7
PKB alpha 98 8
PKB beta 100 1
SGK1 99 4
S6K1 81 1
PKA 79 3
ROCK 2 32 0
PRK2 62 3
PKC alpha 107 3
PKC zeta 97 0
PKD1 87 3
MSK1 65 6
MNK1 104 10
MNK2 109 15
MAPKAP-K2 110 7
MAPKAP-K3 110 9
PRAK 107 1
CAMKK beta 98 1
CAMK1 115 1
SmMLCK 98 11
PHK 101 3
DAPK1 81 1
CHK1 117 4
CHK2 96 9
GSK3 beta 90 3
CDK2-Cyclin A 99 6
PLK1 112 9
Aurora A 107 13
Aurora B 101 0
LKB1 91 12
AMPK 111 0
MARK1 124 15
MARK2 99 3
MARK3 101 2
MARK4 104 7
BRSK1 81 8
BRSK2 105 2
MELK 105 1
NUAK1 71 1
CK1 delta 100 5
CK2 110 6
DYRK1A 98 0
DYRK2 109 6
DYRK3 90 3
NEK2a 81 3
NEK6 102 11
IKK beta 102 3
IKK epsilon 109 11
TBK1 105 2
PIM1 106 13
PIM2 100 6
PIM3 94 3
SRPK1 110 7
EF2K 104 2
HIPK1 97 6
HIPK2 113 1
HIPK3 95 3
CLK2 95 1
PAK2 102 1
PAK4 84 8
PAK5 104 11
PAK6 107 1
MST2 104 5
MST4 92 3
GCK 105 5
MINK1 105 9
MEKK1 98 10
MLK1 95 5
MLK3 84 1
TAO1 120 3
ASK1 124 0
TAK1 88 5
IRAK4 99 4
RIPK2 102 8
TTK 100 5
Src 102 2
Lck 127 8
CSK 107 11
YES1 102 4
BTK 96 3
JAK2 90 2
SYK 121 4
EPH-A2 111 1
EPH-A4 119 1
EPH-B1 103 4
EPH-B2 127 14
EPH-B3 95 11
EPH-B4 108 9
FGF-R1 106 7
HER4 103 10
IGF-1R 110 6
IR 121 5
IRR 110 6
TrkA 99 3
VEGFR1 106 1

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