Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
H-89, Dihydrochloride C20H20BrN3O2S • 2HCl 519.3 PKA Leemhuis J. (2002) J. Pharmacol. Exp. Ther. 300 1000 Davies S.P. (2000) Biochem. J. 351 95 WO2003080649 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort ascending Standard Deviation
ZAP70 124 9
IR 114 13
TGFBR1 113 6
TTBK1 110 25
CK1 gamma 2 107 14
EF2K 106 0
TTK 106 2
PIM2 105 4
CK2 102 9
HIPK3 102 3
NEK6 102 9
p38 beta MAPK 101 4
EPH-B4 101 5
ABL 101 4
TTBK2 100 4
p38 alpha MAPK 100 5
EPH-B1 100 11
MPSK1 100 2
JNK2 99 4
ASK1 99 4
RIPK2 99 1
CSK 99 4
MKK6 97 0
HIPK1 97 13
OSR1 97 2
HIPK2 96 11
p38 gamma MAPK 96 4
IKK epsilon 96 12
PDK1 95 3
MEKK1 94 4
SYK 94 11
MAP4K5 94 0
PAK2 94 8
EPH-B2 94 9
NEK2a 94 8
Src 94 6
IKK beta 94 3
ERK2 93 5
JNK1 93 3
JNK3 93 0
TESK1 93 7
DYRK1A 93 1
PLK1 93 2
DYRK2 93 5
SRPK1 91 1
TIE2 91 10
GSK3 beta 91 5
MAPKAP-K3 91 1
EIF2AK3 90 23
TLK1 88 15
TBK1 88 6
PIM1 87 2
MNK1 87 1
MNK2 87 3
JAK2 86 6
BRK 86 7
CAMKK beta 85 6
WNK1 85 17
DDR2 85 20
YES1 85 5
PAK5 84 0
HER4 84 12
TrkA 83 12
IRAK4 83 5
ERK1 81 4
PIM3 81 3
EPH-A4 81 9
ERK5 81 16
BTK 79 8
LKB1 78 8
PKC alpha 77 2
Lck 77 7
EPH-A2 76 4
p38 delta MAPK 75 4
IRR 73 2
CK1 delta 72 2
EPH-B3 72 5
ULK1 71 5
ULK2 71 9
SIK3 71 0
SmMLCK 70 6
MLK3 70 1
PAK6 68 7
TAK1 67 2
PDGFRA 67 11
TSSK1 66 20
TAO1 65 4
CDK9-Cyclin T1 65 1
PAK4 65 1
PRAK 65 4
MARK4 63 9
MARK1 62 8
MST2 57 0
IGF-1R 57 3
Aurora A 56 3
CLK2 55 1
MAPKAP-K2 55 1
PHK 54 5
MKK1 54 3
MST4 53 10
MLK1 51 3
SIK2 50 2
MST3 49 1
MAP4K3 49 8
CAMK1 47 0
MKK2 46 3
Aurora B 45 1
DAPK1 44 2
CDK2-Cyclin A 41 4
BRSK1 39 7
IRAK1 39 4
MELK 38 4
PKC gamma 38 2
PKC zeta 35 2
MARK2 35 4
MINK1 34 1
PKD1 31 2
BRSK2 30 1
MARK3 29 4
FGF-R1 27 9
AMPK 26 1
CHK1 24 4
GCK 24 1
RSK2 19 2
SGK1 16 0
DYRK3 15 2
CHK2 14 1
AMPK (hum) 14 6
VEGFR1 13 1
ERK8 13 0
PKB beta 12 1
STK33 11 0
RSK1 8 1
ROCK 2 6 1
PRK2 6 4
MSK1 5 0
PKB alpha 5 2
NUAK1 4 1
S6K1 3 0
PKA 1 0
Screening Concentration: 1µM
Kinase % Activity Remainingsort ascending Standard Deviation
EF2K 120 1
TIE2 117 1
HIPK2 111 2
SIK3 109 7
OSR1 109 20
HIPK3 108 7
TrkA 107 1
ZAP70 107 3
ERK5 107 14
TGFBR1 106 3
IKK epsilon 105 6
TTBK1 105 14
PKC zeta 105 7
MAP4K5 105 14
DYRK2 105 9
NEK6 104 6
MAPKAP-K3 104 0
CAMK1 104 1
JAK2 104 0
IRAK4 104 7
NEK2a 102 7
HER4 102 2
IR 102 19
ERK8 102 9
HIPK1 101 8
p38 gamma MAPK 101 1
p38 beta MAPK 100 1
EPH-B2 100 5
IRAK1 100 3
EPH-B3 100 1
YES1 99 2
MPSK1 99 6
ULK1 98 4
MAPKAP-K2 98 9
IKK beta 98 2
BTK 98 8
PDGFRA 98 6
MARK4 98 8
CK2 98 3
TESK1 98 19
p38 delta MAPK 98 3
MNK2 97 1
ULK2 97 1
JNK3 97 0
EPH-A2 97 5
EPH-A4 97 7
EPH-B1 97 6
PAK2 97 5
Src 96 7
SYK 96 3
CK1 gamma 2 96 0
MARK1 95 8
PRAK 95 5
DDR2 95 11
TTBK2 95 6
ASK1 95 1
DYRK1A 95 7
CLK2 95 1
TLK1 94 12
ABL 94 4
CAMKK beta 94 4
DAPK1 94 5
MNK1 93 1
PAK6 93 0
GCK 93 9
JNK2 93 5
p38 alpha MAPK 93 0
MAP4K3 93 8
MST3 92 2
RIPK2 92 11
PLK1 92 0
PAK5 91 2
TBK1 91 29
ERK2 91 4
MLK1 91 0
FGF-R1 90 10
MARK2 90 4
MEKK1 90 9
JNK1 90 1
PAK4 90 1
EPH-B4 89 0
CDK9-Cyclin T1 89 0
PIM1 89 2
VEGFR1 89 4
SRPK1 89 4
CSK 88 4
MST4 88 4
IGF-1R 88 2
IRR 88 6
MLK3 88 0
BRK 88 6
GSK3 beta 88 3
Aurora A 88 3
TAO1 87 2
TAK1 87 2
MKK6 86 2
ERK1 86 2
SmMLCK 86 6
CK1 delta 86 8
BRSK1 85 8
SIK2 84 0
MKK2 83 6
MINK1 82 5
BRSK2 82 4
CHK2 82 0
PDK1 81 6
WNK1 79 2
PIM2 77 7
LKB1 76 1
CDK2-Cyclin A 75 4
TTK 75 0
MKK1 73 7
Lck 72 3
MST2 72 6
DYRK3 72 0
PKC gamma 71 4
AMPK (hum) 70 2
EIF2AK3 69 17
MARK3 67 3
CHK1 67 0
PHK 66 3
PKD1 64 7
Aurora B 63 8
TSSK1 63 10
PKC alpha 63 3
SGK1 61 0
PIM3 59 0
MELK 42 0
STK33 42 3
RSK2 40 7
RSK1 24 0
AMPK 24 0
NUAK1 18 1
PKB alpha 14 0
PKB beta 13 3
S6K1 10 0
MSK1 7 2
PKA 6 0
PRK2 6 2
ROCK 2 5 0

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