Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
H-89, Dihydrochloride C20H20BrN3O2S • 2HCl 519.3 PKA Leemhuis J. (2002) J. Pharmacol. Exp. Ther. 300 1000 Davies S.P. (2000) Biochem. J. 351 95 WO2003080649 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 54 3
MKK2 46 3
MKK6 97 0
ERK1 81 4
ERK2 93 5
ERK5 81 16
JNK1 93 3
JNK2 99 4
JNK3 93 0
p38 alpha MAPK 100 5
p38 beta MAPK 101 4
p38 gamma MAPK 96 4
p38 delta MAPK 75 4
ERK8 13 0
RSK1 8 1
RSK2 19 2
PDK1 95 3
PKB alpha 5 2
PKB beta 12 1
SGK1 16 0
S6K1 3 0
PKA 1 0
ROCK 2 6 1
PRK2 6 4
PKC alpha 77 2
PKC gamma 38 2
PKC zeta 35 2
PKD1 31 2
STK33 11 0
MSK1 5 0
MNK1 87 1
MNK2 87 3
MAPKAP-K2 55 1
MAPKAP-K3 91 1
PRAK 65 4
CAMKK beta 85 6
CAMK1 47 0
SmMLCK 70 6
PHK 54 5
DAPK1 44 2
CHK1 24 4
CHK2 14 1
GSK3 beta 91 5
CDK2-Cyclin A 41 4
CDK9-Cyclin T1 65 1
PLK1 93 2
Aurora A 56 3
Aurora B 45 1
TLK1 88 15
LKB1 78 8
AMPK 26 1
AMPK (hum) 14 6
MARK1 62 8
MARK2 35 4
MARK3 29 4
MARK4 63 9
BRSK1 39 7
BRSK2 30 1
MELK 38 4
NUAK1 4 1
SIK2 50 2
SIK3 71 0
TSSK1 66 20
CK1 gamma 2 107 14
CK1 delta 72 2
CK2 102 9
TTBK1 110 25
TTBK2 100 4
DYRK1A 93 1
DYRK2 93 5
DYRK3 15 2
NEK2a 94 8
NEK6 102 9
IKK beta 94 3
IKK epsilon 96 12
TBK1 88 6
PIM1 87 2
PIM2 105 4
PIM3 81 3
SRPK1 91 1
EF2K 106 0
EIF2AK3 90 23
HIPK1 97 13
HIPK2 96 11
HIPK3 102 3
CLK2 55 1
PAK2 94 8
PAK4 65 1
PAK5 84 0
PAK6 68 7
MST2 57 0
MST3 49 1
MST4 53 10
GCK 24 1
MAP4K3 49 8
MAP4K5 94 0
MINK1 34 1
MEKK1 94 4
MLK1 51 3
MLK3 70 1
TESK1 93 7
TAO1 65 4
ASK1 99 4
TAK1 67 2
IRAK1 39 4
IRAK4 83 5
RIPK2 99 1
OSR1 97 2
TTK 106 2
MPSK1 100 2
WNK1 85 17
ULK1 71 5
ULK2 71 9
TGFBR1 113 6
Src 94 6
Lck 77 7
CSK 99 4
YES1 85 5
ABL 101 4
BTK 79 8
JAK2 86 6
SYK 94 11
ZAP70 124 9
TIE2 91 10
BRK 86 7
EPH-A2 76 4
EPH-A4 81 9
EPH-B1 100 11
EPH-B2 94 9
EPH-B3 72 5
EPH-B4 101 5
FGF-R1 27 9
HER4 84 12
IGF-1R 57 3
IR 114 13
IRR 73 2
TrkA 83 12
DDR2 85 20
VEGFR1 13 1
PDGFRA 67 11
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 73 7
MKK2 83 6
MKK6 86 2
ERK1 86 2
ERK2 91 4
ERK5 107 14
JNK1 90 1
JNK2 93 5
JNK3 97 0
p38 alpha MAPK 93 0
p38 beta MAPK 100 1
p38 gamma MAPK 101 1
p38 delta MAPK 98 3
ERK8 102 9
RSK1 24 0
RSK2 40 7
PDK1 81 6
PKB alpha 14 0
PKB beta 13 3
SGK1 61 0
S6K1 10 0
PKA 6 0
ROCK 2 5 0
PRK2 6 2
PKC alpha 63 3
PKC gamma 71 4
PKC zeta 105 7
PKD1 64 7
STK33 42 3
MSK1 7 2
MNK1 93 1
MNK2 97 1
MAPKAP-K2 98 9
MAPKAP-K3 104 0
PRAK 95 5
CAMKK beta 94 4
CAMK1 104 1
SmMLCK 86 6
PHK 66 3
DAPK1 94 5
CHK1 67 0
CHK2 82 0
GSK3 beta 88 3
CDK2-Cyclin A 75 4
CDK9-Cyclin T1 89 0
PLK1 92 0
Aurora A 88 3
Aurora B 63 8
TLK1 94 12
LKB1 76 1
AMPK 24 0
AMPK (hum) 70 2
MARK1 95 8
MARK2 90 4
MARK3 67 3
MARK4 98 8
BRSK1 85 8
BRSK2 82 4
MELK 42 0
NUAK1 18 1
SIK2 84 0
SIK3 109 7
TSSK1 63 10
CK1 gamma 2 96 0
CK1 delta 86 8
CK2 98 3
TTBK1 105 14
TTBK2 95 6
DYRK1A 95 7
DYRK2 105 9
DYRK3 72 0
NEK2a 102 7
NEK6 104 6
IKK beta 98 2
IKK epsilon 105 6
TBK1 91 29
PIM1 89 2
PIM2 77 7
PIM3 59 0
SRPK1 89 4
EF2K 120 1
EIF2AK3 69 17
HIPK1 101 8
HIPK2 111 2
HIPK3 108 7
CLK2 95 1
PAK2 97 5
PAK4 90 1
PAK5 91 2
PAK6 93 0
MST2 72 6
MST3 92 2
MST4 88 4
GCK 93 9
MAP4K3 93 8
MAP4K5 105 14
MINK1 82 5
MEKK1 90 9
MLK1 91 0
MLK3 88 0
TESK1 98 19
TAO1 87 2
ASK1 95 1
TAK1 87 2
IRAK1 100 3
IRAK4 104 7
RIPK2 92 11
OSR1 109 20
TTK 75 0
MPSK1 99 6
WNK1 79 2
ULK1 98 4
ULK2 97 1
TGFBR1 106 3
Src 96 7
Lck 72 3
CSK 88 4
YES1 99 2
ABL 94 4
BTK 98 8
JAK2 104 0
SYK 96 3
ZAP70 107 3
TIE2 117 1
BRK 88 6
EPH-A2 97 5
EPH-A4 97 7
EPH-B1 97 6
EPH-B2 100 5
EPH-B3 100 1
EPH-B4 89 0
FGF-R1 90 10
HER4 102 2
IGF-1R 88 2
IR 102 19
IRR 88 6
TrkA 107 1
DDR2 95 11
VEGFR1 89 4
PDGFRA 98 6

Do you need any help? Please get in touch and we’ll be happy to lend a hand.