Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
GW5074 (Raf1 Kinase Inhibitor I) C15H8Br2INO2 520.9 cRAF1 Lackey K. (2000) Bioorg. Med. Chem. Lett. 10 223 WO2010036813 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
PIM1 0 0
PIM3 0 0
DYRK1A 1 1
PIM2 1 0
MST2 1 0
RSK2 4 1
HIPK2 4 0
DYRK3 4 0
RSK1 5 1
GSK3 beta 6 0
HIPK3 8 1
DYRK2 8 1
Lck 8 0
PLK1 8 3
CK2 9 0
ROCK 2 9 2
Aurora B 10 1
CHK2 12 1
SRPK1 12 2
PHK 14 2
p38 alpha MAPK 16 4
MARK3 16 1
ERK8 19 0
MELK 21 0
CAMKK beta 22 1
PKD1 28 2
SmMLCK 29 4
PRAK 31 0
Aurora C 32 7
PAK4 36 3
PKC zeta 36 1
MKK1 38 5
AMPK 38 0
SGK1 39 4
S6K1 39 4
MAPKAP-K3 40 2
PKC alpha 41 1
MSK1 41 2
p38 beta MAPK 42 4
NEK2a 44 7
IKK beta 45 6
CAMKK alpha 48 1
CAMK1 48 3
PRK2 48 7
Src 50 1
PKA 53 4
JNK3 53 2
PKB beta 59 6
PDK1 61 7
JNK2 61 1
MNK2 63 2
MAPKAP-K2 65 5
PAK5 66 4
JNK1 66 4
CK1 delta 71 4
MNK1 73 4
p38 gamma MAPK 77 5
PKB alpha 78 7
CDK2-Cyclin A 79 2
PAK6 82 4
CSK 84 1
p38 delta MAPK 84 0
ERK1 86 5
CHK1 86 2
ERK2 89 0
NEK6 92 8
BRSK2 96 0
EF2K 100 2
NEK7 103 1
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
PIM2 5 0
PIM3 8 0
PIM1 13 0
HIPK2 38 5
MST2 40 4
DYRK3 42 0
FGF-R1 49 7
CAMKK alpha 51 6
GSK3 beta 54 2
IRR 57 2
Aurora B 60 2
DYRK1A 62 4
CAMKK beta 63 3
Lck 63 0
RSK1 65 1
ROCK 2 66 1
ERK8 68 2
CK2 68 3
SmMLCK 68 5
RSK2 70 2
TBK1 72 2
MKK1 73 7
Src 74 7
CHK2 75 4
p38 alpha MAPK 77 2
MELK 78 3
SRPK1 79 3
HIPK3 79 8
PHK 79 2
MSK1 80 4
PLK1 81 7
PKB beta 82 5
SGK1 82 1
NEK6 82 7
NEK2a 83 3
MAPKAP-K2 84 7
DYRK2 84 9
CHK1 85 8
IKK epsilon 87 9
CAMK1 89 2
ERK2 89 6
MNK1 90 6
PKB alpha 90 3
SYK 91 7
MNK2 91 5
PRK2 91 6
JNK3 91 2
Aurora C 92 4
MARK3 92 0
CSK 92 11
PKC alpha 92 7
BRSK2 93 2
CK1 delta 93 5
IKK beta 93 6
JNK1 94 5
NEK7 94 4
YES1 95 4
MAPKAP-K3 95 5
PAK4 95 9
JNK2 96 8
p38 delta MAPK 97 3
AMPK 97 4
PRAK 97 8
PAK5 97 1
CDK2-Cyclin A 97 3
PDK1 98 4
S6K1 98 5
PAK6 98 8
ERK1 99 3
PKD1 99 4
EPH-A2 99 11
MST4 99 3
p38 beta MAPK 100 4
PKC zeta 103 9
EF2K 105 3
p38 gamma MAPK 107 7
PKA 109 2

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