Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
GW5074 (Raf1 Kinase Inhibitor I) C15H8Br2INO2 520.9 cRAF1 Lackey K. (2000) Bioorg. Med. Chem. Lett. 10 223 WO2010036813 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 38 5
ERK1 86 5
ERK2 89 0
JNK1 66 4
JNK2 61 1
JNK3 53 2
p38 alpha MAPK 16 4
p38 beta MAPK 42 4
p38 gamma MAPK 77 5
p38 delta MAPK 84 0
ERK8 19 0
RSK1 5 1
RSK2 4 1
PDK1 61 7
PKB alpha 78 7
PKB beta 59 6
SGK1 39 4
S6K1 39 4
PKA 53 4
ROCK 2 9 2
PRK2 48 7
PKC alpha 41 1
PKC zeta 36 1
PKD1 28 2
MSK1 41 2
MNK1 73 4
MNK2 63 2
MAPKAP-K2 65 5
MAPKAP-K3 40 2
PRAK 31 0
CAMKK alpha 48 1
CAMKK beta 22 1
CAMK1 48 3
SmMLCK 29 4
PHK 14 2
CHK1 86 2
CHK2 12 1
GSK3 beta 6 0
CDK2-Cyclin A 79 2
PLK1 8 3
Aurora B 10 1
Aurora C 32 7
AMPK 38 0
MARK3 16 1
BRSK2 96 0
MELK 21 0
CK1 delta 71 4
CK2 9 0
DYRK1A 1 1
DYRK2 8 1
DYRK3 4 0
NEK2a 44 7
NEK6 92 8
NEK7 103 1
IKK beta 45 6
PIM1 0 0
PIM2 1 0
PIM3 0 0
SRPK1 12 2
EF2K 100 2
HIPK2 4 0
HIPK3 8 1
PAK4 36 3
PAK5 66 4
PAK6 82 4
MST2 1 0
Src 50 1
Lck 8 0
CSK 84 1
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 73 7
ERK1 99 3
ERK2 89 6
JNK1 94 5
JNK2 96 8
JNK3 91 2
p38 alpha MAPK 77 2
p38 beta MAPK 100 4
p38 gamma MAPK 107 7
p38 delta MAPK 97 3
ERK8 68 2
RSK1 65 1
RSK2 70 2
PDK1 98 4
PKB alpha 90 3
PKB beta 82 5
SGK1 82 1
S6K1 98 5
PKA 109 2
ROCK 2 66 1
PRK2 91 6
PKC alpha 92 7
PKC zeta 103 9
PKD1 99 4
MSK1 80 4
MNK1 90 6
MNK2 91 5
MAPKAP-K2 84 7
MAPKAP-K3 95 5
PRAK 97 8
CAMKK alpha 51 6
CAMKK beta 63 3
CAMK1 89 2
SmMLCK 68 5
PHK 79 2
CHK1 85 8
CHK2 75 4
GSK3 beta 54 2
CDK2-Cyclin A 97 3
PLK1 81 7
Aurora B 60 2
Aurora C 92 4
AMPK 97 4
MARK3 92 0
BRSK2 93 2
MELK 78 3
CK1 delta 93 5
CK2 68 3
DYRK1A 62 4
DYRK2 84 9
DYRK3 42 0
NEK2a 83 3
NEK6 82 7
NEK7 94 4
IKK beta 93 6
IKK epsilon 87 9
TBK1 72 2
PIM1 13 0
PIM2 5 0
PIM3 8 0
SRPK1 79 3
EF2K 105 3
HIPK2 38 5
HIPK3 79 8
PAK4 95 9
PAK5 97 1
PAK6 98 8
MST2 40 4
MST4 99 3
Src 74 7
Lck 63 0
CSK 92 11
YES1 95 4
SYK 91 7
EPH-A2 99 11
FGF-R1 49 7
IRR 57 2

Do you need any help? Please get in touch and we’ll be happy to lend a hand.