Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Gö 7874 C27H26N4O4 • HCl 507 PKC Kleinschroth J. (1995) Bioorg. Med. Chem. Lett. 5 55 US20080153903 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
0.1µM
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
RSK2 0 0
PKC alpha 1 0
PIM1 1 0
PIM3 1 1
S6K1 2 0
MSK1 3 0
MST2 3 0
RSK1 5 2
PIM2 6 0
SmMLCK 6 2
PKA 7 1
PDK1 11 1
CHK1 13 0
PRK2 13 0
Aurora C 13 0
Aurora B 14 2
PHK 17 2
BRSK2 18 5
AMPK 19 1
GSK3 beta 20 1
MELK 20 4
SGK1 25 1
CHK2 27 2
MKK1 27 0
PKB alpha 34 1
PKB beta 44 1
ERK8 53 2
HIPK2 55 0
CAMK1 55 6
DYRK3 57 3
JNK2 63 3
p38 delta MAPK 65 7
DYRK2 65 6
MARK3 68 3
CAMKK beta 68 3
DYRK1A 68 0
PKC zeta 74 2
Lck 75 3
CSK 78 0
NEK2a 80 5
MNK1 80 1
PAK5 81 3
PAK4 82 0
PAK6 82 2
CK1 delta 83 7
CK2 83 8
NEK7 84 3
PKD1 84 1
NEK6 87 1
MNK2 88 2
SRPK1 89 3
CDK2-Cyclin A 90 4
p38 gamma MAPK 90 4
MAPKAP-K3 92 1
MAPKAP-K2 93 2
IKK beta 94 2
Src 95 4
JNK3 97 2
CAMKK alpha 97 3
PLK1 98 4
JNK1 99 8
p38 beta MAPK 102 2
ERK1 102 3
PRAK 103 0
p38 alpha MAPK 106 5
EF2K 106 3
HIPK3 106 0
ERK2 110 5
ROCK 2 115 6
Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
RSK2 0 0
S6K1 1 0
PKC alpha 1 0
PIM2 1 0
PIM3 1 0
PKA 2 0
PIM1 2 3
MST2 2 0
PDK1 3 0
SmMLCK 3 1
MSK1 3 0
CHK1 4 0
PRK2 4 0
GSK3 beta 5 1
RSK1 5 4
SGK1 6 0
BRSK2 6 0
Aurora C 7 4
MELK 8 0
PKB alpha 8 1
CHK2 10 1
PHK 11 1
Aurora B 12 2
PKB beta 13 0
MKK1 16 5
CAMK1 16 3
HIPK2 24 0
DYRK3 24 2
AMPK 24 8
MARK3 33 5
JNK2 35 4
CAMKK beta 37 4
p38 delta MAPK 37 2
DYRK1A 41 3
Lck 41 2
PKD1 47 0
ERK8 54 1
CSK 58 4
HIPK3 59 6
NEK2a 59 3
JNK1 60 2
PKC zeta 62 5
MNK1 62 11
MAPKAP-K2 62 0
Src 63 3
PAK4 66 0
CK1 delta 68 5
DYRK2 70 3
MNK2 70 5
CK2 71 5
PAK6 71 0
p38 gamma MAPK 74 3
SRPK1 77 13
PLK1 79 0
MAPKAP-K3 79 4
IKK beta 80 5
CDK2-Cyclin A 81 1
NEK7 82 2
NEK6 84 0
PAK5 85 2
p38 alpha MAPK 86 8
JNK3 87 1
p38 beta MAPK 95 4
ERK1 96 5
CAMKK alpha 101 4
ERK2 106 2
PRAK 108 5
EF2K 108 12
ROCK 2 112 6
Screening Concentration: 0.1µM
Kinase % Activity Remainingsort descending Standard Deviation
PIM3 2 0
RSK2 3 1
PKC alpha 5 0
PIM1 9 1
RSK1 10 8
MSK1 11 2
S6K1 11 0
SmMLCK 15 1
Aurora B 17 0
MST2 20 0
PIM2 38 1
PKA 42 4
Aurora C 48 9
PDK1 48 3
CHK1 56 5
CHK2 57 3
PRK2 63 0
AMPK 64 8
GSK3 beta 67 2
SGK1 69 3
PKB alpha 70 0
BRSK2 72 5
MELK 72 7
PHK 77 14
ERK8 78 5
CAMK1 79 0
PKB beta 80 2
MKK1 82 2
CSK 84 4
PKD1 87 9
p38 delta MAPK 89 4
MNK2 90 0
JNK3 90 9
DYRK3 92 2
JNK2 92 4
MARK3 93 4
MNK1 94 4
ERK1 94 7
NEK7 94 9
NEK2a 95 4
CDK2-Cyclin A 95 2
DYRK1A 96 4
HIPK2 97 7
DYRK2 98 9
PLK1 99 4
p38 gamma MAPK 99 2
PAK4 99 2
NEK6 99 0
CK1 delta 103 1
JNK1 103 13
Lck 103 1
PRAK 104 8
Src 104 2
IKK beta 104 3
CK2 105 4
EF2K 106 0
MAPKAP-K2 107 0
PAK6 107 5
p38 alpha MAPK 107 12
HIPK3 108 11
PAK5 108 5
CAMKK alpha 109 13
SRPK1 113 3
CAMKK beta 113 5
ERK2 114 5
ROCK 2 118 0
PKC zeta 118 0
p38 beta MAPK 119 9
MAPKAP-K3 131 2

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