Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Gö 7874 C27H26N4O4 • HCl 507 PKC Kleinschroth J. (1995) Bioorg. Med. Chem. Lett. 5 55 US20080153903 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
0.1µM
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 16 5
ERK1 96 5
ERK2 106 2
JNK1 60 2
JNK2 35 4
JNK3 87 1
p38 alpha MAPK 86 8
p38 beta MAPK 95 4
p38 gamma MAPK 74 3
p38 delta MAPK 37 2
ERK8 54 1
RSK1 5 4
RSK2 0 0
PDK1 3 0
PKB alpha 8 1
PKB beta 13 0
SGK1 6 0
S6K1 1 0
PKA 2 0
ROCK 2 112 6
PRK2 4 0
PKC alpha 1 0
PKC zeta 62 5
PKD1 47 0
MSK1 3 0
MNK1 62 11
MNK2 70 5
MAPKAP-K2 62 0
MAPKAP-K3 79 4
PRAK 108 5
CAMKK alpha 101 4
CAMKK beta 37 4
CAMK1 16 3
SmMLCK 3 1
PHK 11 1
CHK1 4 0
CHK2 10 1
GSK3 beta 5 1
CDK2-Cyclin A 81 1
PLK1 79 0
Aurora B 12 2
Aurora C 7 4
AMPK 24 8
MARK3 33 5
BRSK2 6 0
MELK 8 0
CK1 delta 68 5
CK2 71 5
DYRK1A 41 3
DYRK2 70 3
DYRK3 24 2
NEK2a 59 3
NEK6 84 0
NEK7 82 2
IKK beta 80 5
PIM1 2 3
PIM2 1 0
PIM3 1 0
SRPK1 77 13
EF2K 108 12
HIPK2 24 0
HIPK3 59 6
PAK4 66 0
PAK5 85 2
PAK6 71 0
MST2 2 0
Src 63 3
Lck 41 2
CSK 58 4
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 82 2
ERK1 94 7
ERK2 114 5
JNK1 103 13
JNK2 92 4
JNK3 90 9
p38 alpha MAPK 107 12
p38 beta MAPK 119 9
p38 gamma MAPK 99 2
p38 delta MAPK 89 4
ERK8 78 5
RSK1 10 8
RSK2 3 1
PDK1 48 3
PKB alpha 70 0
PKB beta 80 2
SGK1 69 3
S6K1 11 0
PKA 42 4
ROCK 2 118 0
PRK2 63 0
PKC alpha 5 0
PKC zeta 118 0
PKD1 87 9
MSK1 11 2
MNK1 94 4
MNK2 90 0
MAPKAP-K2 107 0
MAPKAP-K3 131 2
PRAK 104 8
CAMKK alpha 109 13
CAMKK beta 113 5
CAMK1 79 0
SmMLCK 15 1
PHK 77 14
CHK1 56 5
CHK2 57 3
GSK3 beta 67 2
CDK2-Cyclin A 95 2
PLK1 99 4
Aurora B 17 0
Aurora C 48 9
AMPK 64 8
MARK3 93 4
BRSK2 72 5
MELK 72 7
CK1 delta 103 1
CK2 105 4
DYRK1A 96 4
DYRK2 98 9
DYRK3 92 2
NEK2a 95 4
NEK6 99 0
NEK7 94 9
IKK beta 104 3
PIM1 9 1
PIM2 38 1
PIM3 2 0
SRPK1 113 3
EF2K 106 0
HIPK2 97 7
HIPK3 108 11
PAK4 99 2
PAK5 108 5
PAK6 107 5
MST2 20 0
Src 104 2
Lck 103 1
CSK 84 4
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 27 0
ERK1 102 3
ERK2 110 5
JNK1 99 8
JNK2 63 3
JNK3 97 2
p38 alpha MAPK 106 5
p38 beta MAPK 102 2
p38 gamma MAPK 90 4
p38 delta MAPK 65 7
ERK8 53 2
RSK1 5 2
RSK2 0 0
PDK1 11 1
PKB alpha 34 1
PKB beta 44 1
SGK1 25 1
S6K1 2 0
PKA 7 1
ROCK 2 115 6
PRK2 13 0
PKC alpha 1 0
PKC zeta 74 2
PKD1 84 1
MSK1 3 0
MNK1 80 1
MNK2 88 2
MAPKAP-K2 93 2
MAPKAP-K3 92 1
PRAK 103 0
CAMKK alpha 97 3
CAMKK beta 68 3
CAMK1 55 6
SmMLCK 6 2
PHK 17 2
CHK1 13 0
CHK2 27 2
GSK3 beta 20 1
CDK2-Cyclin A 90 4
PLK1 98 4
Aurora B 14 2
Aurora C 13 0
AMPK 19 1
MARK3 68 3
BRSK2 18 5
MELK 20 4
CK1 delta 83 7
CK2 83 8
DYRK1A 68 0
DYRK2 65 6
DYRK3 57 3
NEK2a 80 5
NEK6 87 1
NEK7 84 3
IKK beta 94 2
PIM1 1 0
PIM2 6 0
PIM3 1 1
SRPK1 89 3
EF2K 106 3
HIPK2 55 0
HIPK3 106 0
PAK4 82 0
PAK5 81 3
PAK6 82 2
MST2 3 0
Src 95 4
Lck 75 3
CSK 78 0

Do you need any help? Please get in touch and we’ll be happy to lend a hand.