Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Gleevec (Imatinib) C29H31N7O 493.6 BCR-ABL Druker B. J. (2000) J. Clin. Invest. 105 3-7 WO2006039533 Tocris Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 94 11
MKK2 104 5
MKK6 98 9
ERK1 86 11
ERK2 83 4
JNK1 90 7
JNK2 85 0
JNK3 79 1
p38 alpha MAPK 106 2
p38 beta MAPK 82 2
p38 gamma MAPK 97 4
p38 delta MAPK 81 2
ERK8 72 4
RSK1 83 8
RSK2 83 14
PDK1 102 5
PKB alpha 77 4
PKB beta 86 12
SGK1 89 0
S6K1 87 13
PKA 105 2
ROCK 2 94 9
PRK2 95 7
PKC alpha 92 5
PKC zeta 96 6
PKD1 91 5
MSK1 86 5
MNK1 95 2
MNK2 85 6
MAPKAP-K2 93 10
MAPKAP-K3 93 4
PRAK 99 0
CAMKK beta 61 7
CAMK1 88 13
SmMLCK 85 10
PHK 86 12
DAPK1 88 10
CHK1 97 7
CHK2 67 7
GSK3 beta 75 0
CDK2-Cyclin A 73 3
PLK1 88 1
Aurora A 91 6
Aurora B 89 7
LKB1 85 5
AMPK 95 6
MARK1 92 10
MARK2 97 7
MARK3 105 6
MARK4 100 2
BRSK1 94 3
BRSK2 100 1
MELK 40 3
NUAK1 54 5
CK1 delta 79 9
CK2 69 6
DYRK1A 93 5
DYRK2 99 9
DYRK3 88 6
NEK2a 110 5
NEK6 90 0
IKK beta 74 8
IKK epsilon 70 6
TBK1 77 4
PIM1 68 4
PIM2 88 2
PIM3 61 3
SRPK1 101 10
EF2K 82 7
HIPK1 84 8
HIPK2 70 6
HIPK3 105 1
CLK2 62 9
PAK2 102 13
PAK4 92 12
PAK5 95 0
PAK6 89 11
MST2 78 2
MST4 102 3
GCK 83 2
MINK1 63 10
MEKK1 99 9
MLK1 71 0
MLK3 74 10
TAO1 75 1
ASK1 101 6
TAK1 81 1
IRAK4 88 8
RIPK2 39 2
TTK 80 2
Src 75 6
Lck 7 1
CSK 61 0
YES1 49 5
BTK 92 0
JAK2 85 6
SYK 70 8
EPH-A2 44 1
EPH-A4 70 4
EPH-B1 90 4
EPH-B2 24 3
EPH-B3 24 0
EPH-B4 89 4
FGF-R1 76 5
HER4 46 4
IGF-1R 80 1
IR 62 9
IRR 87 8
TrkA 52 8
VEGFR1 56 7
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 68 3
MKK2 101 11
MKK6 85 2
ERK1 82 6
ERK2 73 9
JNK1 100 6
JNK2 87 7
JNK3 96 7
p38 alpha MAPK 98 14
p38 beta MAPK 75 2
p38 gamma MAPK 93 9
p38 delta MAPK 85 5
ERK8 77 8
RSK1 81 4
RSK2 83 6
PDK1 90 2
PKB alpha 81 2
PKB beta 84 9
SGK1 85 3
S6K1 86 1
PKA 97 2
ROCK 2 83 3
PRK2 91 2
PKC alpha 86 3
PKC zeta 87 9
PKD1 95 1
MSK1 84 5
MNK1 99 2
MNK2 107 8
MAPKAP-K2 98 9
MAPKAP-K3 81 2
PRAK 94 2
CAMKK beta 83 1
CAMK1 91 13
SmMLCK 88 3
PHK 85 3
DAPK1 90 2
CHK1 86 3
CHK2 99 7
GSK3 beta 72 7
CDK2-Cyclin A 83 0
PLK1 91 1
Aurora A 111 10
Aurora B 88 8
LKB1 84 7
AMPK 93 5
MARK1 93 7
MARK2 89 3
MARK3 88 1
MARK4 98 14
BRSK1 98 12
BRSK2 80 3
MELK 76 4
NUAK1 78 4
CK1 delta 87 8
CK2 76 8
DYRK1A 103 1
DYRK2 87 9
DYRK3 84 0
NEK2a 98 11
NEK6 88 0
IKK beta 74 6
IKK epsilon 54 14
TBK1 83 1
PIM1 96 1
PIM2 101 9
PIM3 83 3
SRPK1 93 0
EF2K 67 5
HIPK1 80 1
HIPK2 89 15
HIPK3 86 7
CLK2 78 4
PAK2 94 5
PAK4 85 4
PAK5 95 7
PAK6 94 0
MST2 82 0
MST4 87 2
GCK 91 2
MINK1 56 9
MEKK1 110 1
MLK1 77 1
MLK3 101 5
TAO1 81 3
ASK1 89 7
TAK1 96 5
IRAK4 95 10
RIPK2 77 11
TTK 81 3
Src 92 8
Lck 29 1
CSK 79 3
YES1 77 6
BTK 88 5
JAK2 75 0
SYK 84 8
EPH-A2 69 7
EPH-A4 101 14
EPH-B1 94 1
EPH-B2 91 8
EPH-B3 54 3
EPH-B4 97 6
FGF-R1 89 6
HER4 67 3
IGF-1R 80 1
IR 48 8
IRR 84 7
TrkA 85 1
VEGFR1 64 7

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