Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Genistein C15H10O5 270.2 Tyrosine-kinases Constantinou A. and Huberman E. (1995) Proc. Soc. Exp. Biol. Med. 208 109 Wei H. (1995) Proc. Soc. Exp. Biol. Med. 208 124 WO1999045920 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
50µM
5µM
10µM
25µM

Results as Table

Screening Concentration: 50µM
Kinase % Activity Remainingsort descending Standard Deviation
CK1 delta 6 4
PIM2 8 0
DYRK1A 11 0
Aurora B 13 2
MNK2 14 5
SmMLCK 19 2
ERK8 19 0
GSK3 beta 20 0
MNK1 22 0
SGK1 25 2
PRK2 39 4
Lck 40 1
MSK1 41 4
CK2 43 10
S6K1 44 1
CHK2 47 4
Src 48 2
RSK1 53 1
RSK2 54 11
MKK1 56 12
AMPK 58 2
PKC alpha 59 0
CAMK1 61 1
ROCK 2 62 3
NEK7 64 0
IKK beta 64 2
JNK1 68 5
CSK 70 3
NEK6 71 4
PKA 71 7
PRAK 73 6
PKB beta 73 1
CHK1 73 6
MST2 73 10
JNK2 73 8
PKD1 73 2
PHK 79 5
PDK1 80 3
MAPKAP-K2 80 0
NEK2a 81 13
SRPK1 82 4
p38 beta MAPK 82 1
p38 gamma MAPK 82 4
CDK2-Cyclin A 83 3
MAPKAP-K3 85 0
PLK1 85 8
MARK3 86 1
EF2K 87 0
p38 delta MAPK 91 4
PKB alpha 96 5
ERK2 101 8
p38 alpha MAPK 114 7
Screening Concentration: 25µM
Kinase % Activity Remainingsort descending Standard Deviation
RIPK2 21 5
GCK 21 3
PIM3 23 1
DYRK3 24 3
PIM1 25 0
DYRK1A 32 3
CLK2 39 0
IRR 43 2
CK1 delta 44 2
DYRK2 46 0
PIM2 48 0
GSK3 beta 50 4
JAK2 50 1
SmMLCK 51 6
DAPK1 57 10
HIPK2 57 3
IGF-1R 61 3
Aurora B 61 1
VEGFR1 62 2
MNK1 63 3
MLK3 64 6
S6K1 67 2
ERK8 67 14
YES1 74 4
MINK1 74 4
Src 75 6
IKK epsilon 75 1
MELK 76 4
MSK1 76 3
PKB beta 76 2
NUAK1 77 9
JNK3 78 10
CDK2-Cyclin A 78 3
TTK 78 5
Aurora A 79 14
CK2 80 8
BTK 80 5
BRSK2 81 5
CHK2 82 9
RSK1 82 4
SGK1 82 3
PRK2 83 13
PKC alpha 83 4
BRSK1 83 9
HER4 84 10
Lck 84 0
TAO1 85 3
ROCK 2 85 2
FGF-R1 85 8
HIPK3 86 3
SRPK1 87 11
EF2K 88 2
JNK1 88 1
IRAK4 89 0
LKB1 89 3
CAMKK beta 89 1
MEKK1 89 9
TBK1 90 7
EPH-A4 90 12
PKC zeta 91 8
PKD1 91 5
PAK2 91 0
MNK2 91 3
CSK 91 1
MST2 91 2
RSK2 91 12
ERK1 92 3
AMPK 92 12
IKK beta 92 2
MARK2 92 10
MKK2 92 15
PRAK 93 8
MKK1 93 4
CHK1 94 15
HIPK1 94 2
JNK2 94 5
p38 delta MAPK 94 3
MAPKAP-K3 94 6
MST4 94 2
CAMK1 95 11
ASK1 96 4
PAK5 96 11
MARK1 96 6
EPH-A2 96 4
EPH-B1 97 7
TAK1 97 2
p38 alpha MAPK 97 1
PAK4 97 5
IR 97 8
PKA 98 1
p38 gamma MAPK 98 10
NEK6 98 7
MLK1 98 5
EPH-B4 99 7
TrkA 99 2
MKK6 99 7
PAK6 100 4
MAPKAP-K2 100 5
PHK 102 11
PLK1 102 2
ERK2 103 8
PDK1 104 10
MARK3 104 1
EPH-B2 105 9
EPH-B3 105 0
NEK2a 106 8
PKB alpha 107 7
MARK4 107 7
p38 beta MAPK 109 9
SYK 110 1
Screening Concentration: 5µM
Kinase % Activity Remainingsort descending Standard Deviation
PIM2 38 4
Aurora B 48 5
CK1 delta 51 0
MNK2 51 1
ERK8 53 5
DYRK1A 53 8
MNK1 57 2
GSK3 beta 57 7
SGK1 65 7
CHK2 67 2
MKK1 68 3
Lck 73 2
NEK2a 74 0
S6K1 74 11
PRK2 74 4
SmMLCK 75 12
PRAK 76 0
CAMK1 77 3
ROCK 2 77 1
JNK2 77 3
IKK beta 78 9
MST2 80 0
JNK1 80 8
p38 delta MAPK 81 20
PKA 81 16
PKC alpha 81 3
CHK1 83 17
p38 alpha MAPK 83 19
AMPK 84 11
NEK7 85 7
MAPKAP-K2 89 6
p38 beta MAPK 90 4
PDK1 90 23
CK2 91 0
PKD1 91 9
SRPK1 92 10
CSK 92 16
MARK3 93 8
MAPKAP-K3 93 8
EF2K 94 2
Src 94 2
PKB beta 96 0
CDK2-Cyclin A 96 3
MSK1 97 2
RSK2 98 0
NEK6 98 1
PLK1 99 14
ERK2 103 3
p38 gamma MAPK 104 13
RSK1 105 15
PKB alpha 105 3
PHK 106 10
Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
PIM3 40 0
RIPK2 48 5
GCK 48 1
DYRK1A 54 2
PIM1 54 0
DYRK3 58 3
IRR 58 2
MNK2 61 5
VEGFR1 70 15
CLK2 71 9
SmMLCK 77 1
DAPK1 77 2
DYRK2 78 5
PAK4 78 4
HIPK2 79 12
PKC alpha 81 3
MST2 81 2
PKB beta 83 6
CHK2 83 4
PAK6 83 9
S6K1 84 8
JAK2 84 9
EPH-A2 85 7
EPH-B1 86 12
IRAK4 86 9
HER4 86 2
MKK1 86 14
EF2K 87 8
MSK1 87 11
MAPKAP-K3 87 1
PDK1 87 3
MELK 88 9
MNK1 88 1
BTK 88 9
PRAK 89 6
PIM2 90 9
CK1 delta 90 7
GSK3 beta 90 0
Aurora B 90 12
EPH-A4 91 0
JNK3 92 6
Src 92 9
CAMK1 93 6
TAO1 93 3
HIPK1 93 4
ASK1 93 9
NEK6 93 2
CAMKK beta 94 8
MLK3 95 3
ROCK 2 95 1
CHK1 95 13
CK2 95 9
p38 gamma MAPK 95 3
IR 95 9
ERK8 95 7
TAK1 96 5
FGF-R1 96 4
IGF-1R 96 3
LKB1 96 2
CSK 96 4
MST4 96 4
PAK5 97 3
RSK1 97 3
AMPK 97 1
MEKK1 98 1
MKK6 98 14
JNK2 98 5
PKD1 98 7
MARK4 99 4
PKC zeta 99 6
PAK2 99 7
TBK1 99 3
SGK1 100 3
BRSK1 100 6
p38 delta MAPK 100 2
EPH-B3 101 6
CDK2-Cyclin A 101 2
p38 beta MAPK 101 11
PLK1 101 10
MKK2 102 7
SRPK1 102 8
HIPK3 102 3
IKK beta 102 8
PKA 103 10
JNK1 103 10
RSK2 103 14
MARK2 103 6
NUAK1 104 2
Lck 104 2
PKB alpha 104 7
PRK2 105 13
TrkA 105 4
YES1 105 13
PHK 106 6
ERK2 106 6
MARK1 106 0
IKK epsilon 106 5
EPH-B4 107 13
TTK 107 5
MAPKAP-K2 108 5
MARK3 108 7
ERK1 109 7
EPH-B2 109 9
MINK1 109 9
Aurora A 110 2
MLK1 114 9
NEK2a 115 5
BRSK2 117 9
p38 alpha MAPK 117 13
SYK 124 9

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