Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Genistein C15H10O5 270.2 Tyrosine-kinases Constantinou A. and Huberman E. (1995) Proc. Soc. Exp. Biol. Med. 208 109 Wei H. (1995) Proc. Soc. Exp. Biol. Med. 208 124 WO1999045920 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
50µM
5µM
10µM
25µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 86 14
MKK2 102 7
MKK6 98 14
ERK1 109 7
ERK2 106 6
JNK1 103 10
JNK2 98 5
JNK3 92 6
p38 alpha MAPK 117 13
p38 beta MAPK 101 11
p38 gamma MAPK 95 3
p38 delta MAPK 100 2
ERK8 95 7
RSK1 97 3
RSK2 103 14
PDK1 87 3
PKB alpha 104 7
PKB beta 83 6
SGK1 100 3
S6K1 84 8
PKA 103 10
ROCK 2 95 1
PRK2 105 13
PKC alpha 81 3
PKC zeta 99 6
PKD1 98 7
MSK1 87 11
MNK1 88 1
MNK2 61 5
MAPKAP-K2 108 5
MAPKAP-K3 87 1
PRAK 89 6
CAMKK beta 94 8
CAMK1 93 6
SmMLCK 77 1
PHK 106 6
DAPK1 77 2
CHK1 95 13
CHK2 83 4
GSK3 beta 90 0
CDK2-Cyclin A 101 2
PLK1 101 10
Aurora A 110 2
Aurora B 90 12
LKB1 96 2
AMPK 97 1
MARK1 106 0
MARK2 103 6
MARK3 108 7
MARK4 99 4
BRSK1 100 6
BRSK2 117 9
MELK 88 9
NUAK1 104 2
CK1 delta 90 7
CK2 95 9
DYRK1A 54 2
DYRK2 78 5
DYRK3 58 3
NEK2a 115 5
NEK6 93 2
IKK beta 102 8
IKK epsilon 106 5
TBK1 99 3
PIM1 54 0
PIM2 90 9
PIM3 40 0
SRPK1 102 8
EF2K 87 8
HIPK1 93 4
HIPK2 79 12
HIPK3 102 3
CLK2 71 9
PAK2 99 7
PAK4 78 4
PAK5 97 3
PAK6 83 9
MST2 81 2
MST4 96 4
GCK 48 1
MINK1 109 9
MEKK1 98 1
MLK1 114 9
MLK3 95 3
TAO1 93 3
ASK1 93 9
TAK1 96 5
IRAK4 86 9
RIPK2 48 5
TTK 107 5
Src 92 9
Lck 104 2
CSK 96 4
YES1 105 13
BTK 88 9
JAK2 84 9
SYK 124 9
EPH-A2 85 7
EPH-A4 91 0
EPH-B1 86 12
EPH-B2 109 9
EPH-B3 101 6
EPH-B4 107 13
FGF-R1 96 4
HER4 86 2
IGF-1R 96 3
IR 95 9
IRR 58 2
TrkA 105 4
VEGFR1 70 15
Screening Concentration: 50µM
Kinase % Activity Remaining Standard Deviation
MKK1 56 12
ERK2 101 8
JNK1 68 5
JNK2 73 8
p38 alpha MAPK 114 7
p38 beta MAPK 82 1
p38 gamma MAPK 82 4
p38 delta MAPK 91 4
ERK8 19 0
RSK1 53 1
RSK2 54 11
PDK1 80 3
PKB alpha 96 5
PKB beta 73 1
SGK1 25 2
S6K1 44 1
PKA 71 7
ROCK 2 62 3
PRK2 39 4
PKC alpha 59 0
PKD1 73 2
MSK1 41 4
MNK1 22 0
MNK2 14 5
MAPKAP-K2 80 0
MAPKAP-K3 85 0
PRAK 73 6
CAMK1 61 1
SmMLCK 19 2
PHK 79 5
CHK1 73 6
CHK2 47 4
GSK3 beta 20 0
CDK2-Cyclin A 83 3
PLK1 85 8
Aurora B 13 2
AMPK 58 2
MARK3 86 1
CK1 delta 6 4
CK2 43 10
DYRK1A 11 0
NEK2a 81 13
NEK6 71 4
NEK7 64 0
IKK beta 64 2
PIM2 8 0
SRPK1 82 4
EF2K 87 0
MST2 73 10
Src 48 2
Lck 40 1
CSK 70 3
Screening Concentration: 5µM
Kinase % Activity Remaining Standard Deviation
MKK1 68 3
ERK2 103 3
JNK1 80 8
JNK2 77 3
p38 alpha MAPK 83 19
p38 beta MAPK 90 4
p38 gamma MAPK 104 13
p38 delta MAPK 81 20
ERK8 53 5
RSK1 105 15
RSK2 98 0
PDK1 90 23
PKB alpha 105 3
PKB beta 96 0
SGK1 65 7
S6K1 74 11
PKA 81 16
ROCK 2 77 1
PRK2 74 4
PKC alpha 81 3
PKD1 91 9
MSK1 97 2
MNK1 57 2
MNK2 51 1
MAPKAP-K2 89 6
MAPKAP-K3 93 8
PRAK 76 0
CAMK1 77 3
SmMLCK 75 12
PHK 106 10
CHK1 83 17
CHK2 67 2
GSK3 beta 57 7
CDK2-Cyclin A 96 3
PLK1 99 14
Aurora B 48 5
AMPK 84 11
MARK3 93 8
CK1 delta 51 0
CK2 91 0
DYRK1A 53 8
NEK2a 74 0
NEK6 98 1
NEK7 85 7
IKK beta 78 9
PIM2 38 4
SRPK1 92 10
EF2K 94 2
MST2 80 0
Src 94 2
Lck 73 2
CSK 92 16
Screening Concentration: 25µM
Kinase % Activity Remaining Standard Deviation
MKK1 93 4
MKK2 92 15
MKK6 99 7
ERK1 92 3
ERK2 103 8
JNK1 88 1
JNK2 94 5
JNK3 78 10
p38 alpha MAPK 97 1
p38 beta MAPK 109 9
p38 gamma MAPK 98 10
p38 delta MAPK 94 3
ERK8 67 14
RSK1 82 4
RSK2 91 12
PDK1 104 10
PKB alpha 107 7
PKB beta 76 2
SGK1 82 3
S6K1 67 2
PKA 98 1
ROCK 2 85 2
PRK2 83 13
PKC alpha 83 4
PKC zeta 91 8
PKD1 91 5
MSK1 76 3
MNK1 63 3
MNK2 91 3
MAPKAP-K2 100 5
MAPKAP-K3 94 6
PRAK 93 8
CAMKK beta 89 1
CAMK1 95 11
SmMLCK 51 6
PHK 102 11
DAPK1 57 10
CHK1 94 15
CHK2 82 9
GSK3 beta 50 4
CDK2-Cyclin A 78 3
PLK1 102 2
Aurora A 79 14
Aurora B 61 1
LKB1 89 3
AMPK 92 12
MARK1 96 6
MARK2 92 10
MARK3 104 1
MARK4 107 7
BRSK1 83 9
BRSK2 81 5
MELK 76 4
NUAK1 77 9
CK1 delta 44 2
CK2 80 8
DYRK1A 32 3
DYRK2 46 0
DYRK3 24 3
NEK2a 106 8
NEK6 98 7
IKK beta 92 2
IKK epsilon 75 1
TBK1 90 7
PIM1 25 0
PIM2 48 0
PIM3 23 1
SRPK1 87 11
EF2K 88 2
HIPK1 94 2
HIPK2 57 3
HIPK3 86 3
CLK2 39 0
PAK2 91 0
PAK4 97 5
PAK5 96 11
PAK6 100 4
MST2 91 2
MST4 94 2
GCK 21 3
MINK1 74 4
MEKK1 89 9
MLK1 98 5
MLK3 64 6
TAO1 85 3
ASK1 96 4
TAK1 97 2
IRAK4 89 0
RIPK2 21 5
TTK 78 5
Src 75 6
Lck 84 0
CSK 91 1
YES1 74 4
BTK 80 5
JAK2 50 1
SYK 110 1
EPH-A2 96 4
EPH-A4 90 12
EPH-B1 97 7
EPH-B2 105 9
EPH-B3 105 0
EPH-B4 99 7
FGF-R1 85 8
HER4 84 10
IGF-1R 61 3
IR 97 8
IRR 43 2
TrkA 99 2
VEGFR1 62 2

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