Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
GDC-0941 C23H29N7O3S2Cl2 586.57 PI3K Folkes AJ. (2008) J Med Chem. 5522-32 WO2007129161 Axon Download

Results as Barchart

View results as a bar chart
0.1µM
10µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
MKK1 11 0
ERK8 15 0
HIPK2 26 6
IRR 33 18
JNK1 34 7
CDK2-Cyclin A 36 4
DYRK2 38 0
YES1 40 7
SGK1 45 1
IGF-1R 46 16
S6K1 46 3
JNK2 48 2
RSK1 52 0
ERK2 53 19
CAMKK beta 54 0
FGF-R1 55 1
PKB beta 57 10
Src 58 10
GSK3 beta 59 5
MSK1 59 2
PIM1 60 6
DYRK3 63 10
p38 alpha MAPK 64 11
Lck 64 0
NEK6 65 11
PIM3 66 2
BRSK2 67 1
MELK 67 8
SmMLCK 67 8
RSK2 69 15
DYRK1A 69 5
CAMK1 69 26
BTK 71 3
PIM2 73 15
CHK2 73 6
ROCK 2 74 3
IKK epsilon 74 0
PAK6 74 3
MST4 75 3
p38 gamma MAPK 75 0
MARK3 75 12
p38 delta MAPK 75 0
MAPKAP-K2 75 11
PLK1 76 3
EF2K 76 11
PKC zeta 77 2
VEGFR1 78 4
PKD1 79 8
PHK 79 18
SYK 80 19
MNK1 80 4
CSK 80 10
IR 82 1
AMPK 83 4
PAK5 83 8
PRK2 84 12
p38 beta MAPK 84 2
PKB alpha 85 0
PKA 85 4
MST2 86 0
CK2 87 3
PDK1 87 7
CHK1 88 16
PAK4 90 0
EPH-A2 90 3
SRPK1 92 18
Aurora B 94 4
CK1 delta 95 3
MNK2 96 2
NEK2a 96 4
ERK1 96 14
PKC alpha 98 11
TBK1 98 6
EPH-B3 99 6
PRAK 108 1
IKK beta 145 95
Screening Concentration: 0.1µM
Kinase % Activity Remainingsort descending Standard Deviation
MKK1 12 0
p38 alpha MAPK 67 12
CAMK1 72 11
PKB beta 75 8
HIPK2 75 9
GSK3 beta 76 2
IKK epsilon 77 7
PKC zeta 79 9
IRR 79 6
SGK1 79 1
NEK6 79 4
EF2K 81 0
DYRK3 82 2
MSK1 83 3
BRSK2 83 1
PKD1 84 4
MARK3 84 8
PAK6 84 1
RSK1 85 7
MAPKAP-K2 85 3
CHK2 85 0
PRK2 85 8
ERK2 86 8
p38 delta MAPK 86 10
MELK 86 6
YES1 87 5
CAMKK beta 87 5
ROCK 2 87 4
p38 beta MAPK 88 5
CDK2-Cyclin A 88 2
MNK1 89 2
RSK2 89 11
VEGFR1 89 2
BTK 89 0
NEK2a 89 4
S6K1 89 3
AMPK 90 5
TBK1 90 4
PLK1 91 6
Lck 91 12
PIM3 92 5
FGF-R1 92 1
JNK1 92 0
CHK1 92 8
Src 92 0
DYRK2 93 5
PKA 93 3
MST2 94 4
ERK8 95 32
PRAK 95 13
IGF-1R 95 7
PAK4 95 0
PAK5 95 3
ERK1 96 14
EPH-B3 96 1
CSK 97 5
PDK1 97 0
PIM2 97 5
PKC alpha 98 4
p38 gamma MAPK 98 2
PKB alpha 98 4
PIM1 98 0
JNK2 99 10
CK2 99 3
DYRK1A 99 4
SmMLCK 99 4
SRPK1 101 9
PHK 101 1
MNK2 102 1
EPH-A2 104 2
SYK 105 11
CK1 delta 106 3
Aurora B 108 18
MST4 110 5
IR 115 7
IKK beta 200 131
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
CLK2 30 2
HIPK2 52 2
LKB1 52 5
DYRK2 63 3
PKB beta 63 8
TrkA 67 6
GSK3 beta 69 6
SmMLCK 70 9
PRK2 71 6
JNK3 72 4
MSK1 72 1
ERK2 72 3
MELK 72 15
ROCK 2 73 2
VEGFR1 74 12
MLK1 74 3
MLK3 74 8
IRAK4 75 1
Src 76 6
AMPK 76 8
MINK1 76 1
HER4 77 8
MKK6 77 10
DAPK1 77 11
p38 alpha MAPK 78 4
NEK2a 78 9
PKD1 79 10
TTK 79 1
ERK8 79 1
BTK 79 4
MARK2 79 6
NUAK1 79 4
TAK1 80 8
PAK5 80 0
TBK1 80 0
MKK1 80 12
CAMKK beta 80 0
HIPK3 81 8
IRR 81 15
S6K1 81 2
PKC zeta 82 3
Aurora B 82 9
MAPKAP-K2 82 2
RSK2 82 0
PIM1 82 13
MKK2 82 0
CAMK1 82 11
JNK2 83 3
CK1 delta 83 2
CSK 83 10
MAPKAP-K3 83 1
IKK epsilon 83 3
GCK 83 4
JAK2 83 4
TAO1 83 5
HIPK1 83 2
ASK1 83 2
RIPK2 84 1
IGF-1R 84 0
YES1 84 2
DYRK3 85 3
PAK4 85 0
CHK1 85 3
RSK1 86 2
IKK beta 87 0
PIM2 87 10
PIM3 87 0
BRSK2 87 0
EPH-B4 88 12
p38 delta MAPK 89 9
PAK6 89 2
PKB alpha 89 7
p38 beta MAPK 90 1
PDK1 90 9
SRPK1 90 1
FGF-R1 91 12
MNK2 91 2
DYRK1A 92 0
MEKK1 92 3
BRSK1 92 8
EPH-B3 92 0
IR 93 7
MST4 93 2
MARK4 93 1
SGK1 93 6
ERK1 93 10
Aurora A 94 12
EPH-B2 94 1
PAK2 95 5
MNK1 95 4
PLK1 96 5
p38 gamma MAPK 96 5
MARK1 97 1
JNK1 97 3
MST2 98 11
PHK 98 7
EF2K 98 4
CHK2 99 5
PKC alpha 99 10
MARK3 99 0
Lck 100 6
NEK6 100 7
PRAK 100 6
SYK 100 7
EPH-A2 100 11
EPH-B1 101 9
CDK2-Cyclin A 103 6
PKA 103 3
CK2 105 3
EPH-A4 107 8

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