Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
GDC-0941 C23H29N7O3S2Cl2 586.57 PI3K Folkes AJ. (2008) J Med Chem. 5522-32 WO2007129161 Axon Download

Results as Barchart

View results as a bar chart
0.1µM
10µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 11 0
ERK1 96 14
ERK2 53 19
JNK1 34 7
JNK2 48 2
p38 alpha MAPK 64 11
p38 beta MAPK 84 2
p38 gamma MAPK 75 0
p38 delta MAPK 75 0
ERK8 15 0
RSK1 52 0
RSK2 69 15
PDK1 87 7
PKB alpha 85 0
PKB beta 57 10
SGK1 45 1
S6K1 46 3
PKA 85 4
ROCK 2 74 3
PRK2 84 12
PKC alpha 98 11
PKC zeta 77 2
PKD1 79 8
MSK1 59 2
MNK1 80 4
MNK2 96 2
MAPKAP-K2 75 11
PRAK 108 1
CAMKK beta 54 0
CAMK1 69 26
SmMLCK 67 8
PHK 79 18
CHK1 88 16
CHK2 73 6
GSK3 beta 59 5
CDK2-Cyclin A 36 4
PLK1 76 3
Aurora B 94 4
AMPK 83 4
MARK3 75 12
BRSK2 67 1
MELK 67 8
CK1 delta 95 3
CK2 87 3
DYRK1A 69 5
DYRK2 38 0
DYRK3 63 10
NEK2a 96 4
NEK6 65 11
IKK beta 145 95
IKK epsilon 74 0
TBK1 98 6
PIM1 60 6
PIM2 73 15
PIM3 66 2
SRPK1 92 18
EF2K 76 11
HIPK2 26 6
PAK4 90 0
PAK5 83 8
PAK6 74 3
MST2 86 0
MST4 75 3
Src 58 10
Lck 64 0
CSK 80 10
YES1 40 7
BTK 71 3
SYK 80 19
EPH-A2 90 3
EPH-B3 99 6
FGF-R1 55 1
IGF-1R 46 16
IR 82 1
IRR 33 18
VEGFR1 78 4
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 12 0
ERK1 96 14
ERK2 86 8
JNK1 92 0
JNK2 99 10
p38 alpha MAPK 67 12
p38 beta MAPK 88 5
p38 gamma MAPK 98 2
p38 delta MAPK 86 10
ERK8 95 32
RSK1 85 7
RSK2 89 11
PDK1 97 0
PKB alpha 98 4
PKB beta 75 8
SGK1 79 1
S6K1 89 3
PKA 93 3
ROCK 2 87 4
PRK2 85 8
PKC alpha 98 4
PKC zeta 79 9
PKD1 84 4
MSK1 83 3
MNK1 89 2
MNK2 102 1
MAPKAP-K2 85 3
PRAK 95 13
CAMKK beta 87 5
CAMK1 72 11
SmMLCK 99 4
PHK 101 1
CHK1 92 8
CHK2 85 0
GSK3 beta 76 2
CDK2-Cyclin A 88 2
PLK1 91 6
Aurora B 108 18
AMPK 90 5
MARK3 84 8
BRSK2 83 1
MELK 86 6
CK1 delta 106 3
CK2 99 3
DYRK1A 99 4
DYRK2 93 5
DYRK3 82 2
NEK2a 89 4
NEK6 79 4
IKK beta 200 131
IKK epsilon 77 7
TBK1 90 4
PIM1 98 0
PIM2 97 5
PIM3 92 5
SRPK1 101 9
EF2K 81 0
HIPK2 75 9
PAK4 95 0
PAK5 95 3
PAK6 84 1
MST2 94 4
MST4 110 5
Src 92 0
Lck 91 12
CSK 97 5
YES1 87 5
BTK 89 0
SYK 105 11
EPH-A2 104 2
EPH-B3 96 1
FGF-R1 92 1
IGF-1R 95 7
IR 115 7
IRR 79 6
VEGFR1 89 2
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 80 12
MKK2 82 0
MKK6 77 10
ERK1 93 10
ERK2 72 3
JNK1 97 3
JNK2 83 3
JNK3 72 4
p38 alpha MAPK 78 4
p38 beta MAPK 90 1
p38 gamma MAPK 96 5
p38 delta MAPK 89 9
ERK8 79 1
RSK1 86 2
RSK2 82 0
PDK1 90 9
PKB alpha 89 7
PKB beta 63 8
SGK1 93 6
S6K1 81 2
PKA 103 3
ROCK 2 73 2
PRK2 71 6
PKC alpha 99 10
PKC zeta 82 3
PKD1 79 10
MSK1 72 1
MNK1 95 4
MNK2 91 2
MAPKAP-K2 82 2
MAPKAP-K3 83 1
PRAK 100 6
CAMKK beta 80 0
CAMK1 82 11
SmMLCK 70 9
PHK 98 7
DAPK1 77 11
CHK1 85 3
CHK2 99 5
GSK3 beta 69 6
CDK2-Cyclin A 103 6
PLK1 96 5
Aurora A 94 12
Aurora B 82 9
LKB1 52 5
AMPK 76 8
MARK1 97 1
MARK2 79 6
MARK3 99 0
MARK4 93 1
BRSK1 92 8
BRSK2 87 0
MELK 72 15
NUAK1 79 4
CK1 delta 83 2
CK2 105 3
DYRK1A 92 0
DYRK2 63 3
DYRK3 85 3
NEK2a 78 9
NEK6 100 7
IKK beta 87 0
IKK epsilon 83 3
TBK1 80 0
PIM1 82 13
PIM2 87 10
PIM3 87 0
SRPK1 90 1
EF2K 98 4
HIPK1 83 2
HIPK2 52 2
HIPK3 81 8
CLK2 30 2
PAK2 95 5
PAK4 85 0
PAK5 80 0
PAK6 89 2
MST2 98 11
MST4 93 2
GCK 83 4
MINK1 76 1
MEKK1 92 3
MLK1 74 3
MLK3 74 8
TAO1 83 5
ASK1 83 2
TAK1 80 8
IRAK4 75 1
RIPK2 84 1
TTK 79 1
Src 76 6
Lck 100 6
CSK 83 10
YES1 84 2
BTK 79 4
JAK2 83 4
SYK 100 7
EPH-A2 100 11
EPH-A4 107 8
EPH-B1 101 9
EPH-B2 94 1
EPH-B3 92 0
EPH-B4 88 12
FGF-R1 91 12
HER4 77 8
IGF-1R 84 0
IR 93 7
IRR 81 15
TrkA 67 6
VEGFR1 74 12

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