Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Curcumin C21H20O6 368.4 Inhibits EGF receptor Cui L. (2007) Antimicrob. Agents Chemother. 51 488 Salvioli S. (2007) eCAM 4 181 WO2000070949 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
PHK 2 0
DYRK2 2 1
DYRK1A 3 0
DYRK3 4 4
MLK3 6 0
GCK 7 1
CLK2 7 0
RIPK2 10 4
HIPK2 11 5
ERK8 11 0
PIM1 12 0
MINK1 12 3
PIM3 12 1
RSK1 15 0
CHK2 16 1
PKB beta 17 1
PIM2 17 0
MLK1 17 1
VEGFR1 18 4
IKK epsilon 21 0
CAMK1 24 4
IRR 24 0
TrkA 25 3
Aurora A 26 5
CAMKK beta 26 1
TTK 28 1
RSK2 29 1
S6K1 30 3
YES1 31 3
FGF-R1 31 6
HIPK3 35 2
IRAK4 35 1
BTK 37 4
MEKK1 38 3
MELK 38 0
MST2 39 1
HER4 39 4
SRPK1 39 4
SmMLCK 40 3
NUAK1 40 3
DAPK1 42 1
TAO1 42 2
PKC alpha 43 2
HIPK1 44 2
TAK1 46 1
ROCK 2 50 4
JAK2 53 1
IR 54 4
MAPKAP-K3 56 2
Aurora B 57 3
PRAK 57 6
MARK2 57 0
Lck 58 4
CDK2-Cyclin A 59 6
IGF-1R 60 8
TBK1 61 2
PAK4 61 2
SYK 62 1
PKD1 63 12
CK2 63 5
PAK5 63 4
PRK2 65 0
GSK3 beta 65 8
CSK 66 4
p38 beta MAPK 68 2
MARK1 68 3
PAK2 69 0
MARK3 70 1
EPH-A2 72 1
EPH-A4 72 2
LKB1 72 3
BRSK1 75 3
EPH-B3 75 13
BRSK2 78 8
MSK1 78 6
MNK1 78 11
Src 78 13
PDK1 78 7
MKK1 78 9
SGK1 79 1
MNK2 79 8
ERK1 80 6
ERK2 80 9
AMPK 81 9
NEK2a 82 7
MARK4 83 7
EPH-B2 83 2
PKB alpha 83 4
PKA 85 1
MST4 86 2
NEK6 88 12
EF2K 89 2
CHK1 90 12
PKC zeta 90 11
p38 delta MAPK 92 5
JNK3 93 7
MAPKAP-K2 94 1
IKK beta 95 6
CK1 delta 96 10
p38 gamma MAPK 96 0
PLK1 97 4
JNK1 98 5
PAK6 99 13
MKK2 100 11
p38 alpha MAPK 102 12
JNK2 107 0
MKK6 112 6
EPH-B1 116 8
ASK1 120 4
EPH-B4 120 1
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
DYRK2 3 1
DYRK3 5 1
MLK3 6 3
PHK 10 1
RIPK2 14 3
PIM3 18 3
DYRK1A 25 1
MLK1 33 3
CLK2 38 1
IRR 39 3
HIPK2 41 2
MINK1 42 5
GCK 43 5
PIM1 48 1
VEGFR1 48 1
YES1 53 4
CAMKK beta 54 1
IGF-1R 55 3
TTK 59 1
MELK 61 5
ERK8 63 9
PIM2 63 3
HER4 64 4
RSK1 66 2
CHK2 68 10
HIPK3 73 10
TAO1 75 3
PAK5 76 9
S6K1 76 3
SmMLCK 77 7
BTK 78 0
SRPK1 80 4
Aurora B 81 10
CAMK1 81 1
p38 gamma MAPK 81 5
JNK3 82 5
PKC alpha 82 12
PAK2 82 2
NEK6 83 4
MEKK1 83 1
PKB beta 84 5
HIPK1 85 10
IRAK4 85 2
TrkA 85 6
EF2K 86 1
MARK3 87 10
ERK1 87 3
DAPK1 87 14
NUAK1 87 7
MAPKAP-K3 88 3
MARK2 88 10
CK2 88 6
p38 beta MAPK 88 13
Aurora A 88 2
MNK1 89 1
IKK epsilon 89 2
LKB1 90 2
PRAK 91 3
TBK1 91 3
FGF-R1 91 2
EPH-A2 92 5
MST4 93 5
CDK2-Cyclin A 93 1
Lck 95 0
MARK1 95 6
MARK4 95 10
EPH-A4 95 7
IR 95 6
PAK4 95 9
PLK1 96 4
CSK 97 4
MST2 97 15
SYK 98 5
SGK1 98 1
PAK6 99 2
EPH-B2 99 5
ROCK 2 99 1
PRK2 99 4
PKD1 101 3
NEK2a 102 3
MAPKAP-K2 102 3
RSK2 102 11
BRSK1 102 0
PKA 102 3
TAK1 102 6
Src 103 10
MNK2 104 1
JAK2 104 7
JNK1 105 0
JNK2 105 13
AMPK 106 12
PKB alpha 106 1
MKK2 106 7
CHK1 106 0
GSK3 beta 106 7
EPH-B1 107 1
EPH-B3 107 5
MSK1 107 4
CK1 delta 108 3
p38 alpha MAPK 108 11
IKK beta 109 5
MKK6 109 10
ERK2 109 14
PDK1 110 11
ASK1 110 3
EPH-B4 111 4
BRSK2 111 2
PKC zeta 118 9
p38 delta MAPK 122 5
MKK1 122 2

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