Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Curcumin C21H20O6 368.4 Inhibits EGF receptor Cui L. (2007) Antimicrob. Agents Chemother. 51 488 Salvioli S. (2007) eCAM 4 181 WO2000070949 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 122 2
MKK2 106 7
MKK6 109 10
ERK1 87 3
ERK2 109 14
JNK1 105 0
JNK2 105 13
JNK3 82 5
p38 alpha MAPK 108 11
p38 beta MAPK 88 13
p38 gamma MAPK 81 5
p38 delta MAPK 122 5
ERK8 63 9
RSK1 66 2
RSK2 102 11
PDK1 110 11
PKB alpha 106 1
PKB beta 84 5
SGK1 98 1
S6K1 76 3
PKA 102 3
ROCK 2 99 1
PRK2 99 4
PKC alpha 82 12
PKC zeta 118 9
PKD1 101 3
MSK1 107 4
MNK1 89 1
MNK2 104 1
MAPKAP-K2 102 3
MAPKAP-K3 88 3
PRAK 91 3
CAMKK beta 54 1
CAMK1 81 1
SmMLCK 77 7
PHK 10 1
DAPK1 87 14
CHK1 106 0
CHK2 68 10
GSK3 beta 106 7
CDK2-Cyclin A 93 1
PLK1 96 4
Aurora A 88 2
Aurora B 81 10
LKB1 90 2
AMPK 106 12
MARK1 95 6
MARK2 88 10
MARK3 87 10
MARK4 95 10
BRSK1 102 0
BRSK2 111 2
MELK 61 5
NUAK1 87 7
CK1 delta 108 3
CK2 88 6
DYRK1A 25 1
DYRK2 3 1
DYRK3 5 1
NEK2a 102 3
NEK6 83 4
IKK beta 109 5
IKK epsilon 89 2
TBK1 91 3
PIM1 48 1
PIM2 63 3
PIM3 18 3
SRPK1 80 4
EF2K 86 1
HIPK1 85 10
HIPK2 41 2
HIPK3 73 10
CLK2 38 1
PAK2 82 2
PAK4 95 9
PAK5 76 9
PAK6 99 2
MST2 97 15
MST4 93 5
GCK 43 5
MINK1 42 5
MEKK1 83 1
MLK1 33 3
MLK3 6 3
TAO1 75 3
ASK1 110 3
TAK1 102 6
IRAK4 85 2
RIPK2 14 3
TTK 59 1
Src 103 10
Lck 95 0
CSK 97 4
YES1 53 4
BTK 78 0
JAK2 104 7
SYK 98 5
EPH-A2 92 5
EPH-A4 95 7
EPH-B1 107 1
EPH-B2 99 5
EPH-B3 107 5
EPH-B4 111 4
FGF-R1 91 2
HER4 64 4
IGF-1R 55 3
IR 95 6
IRR 39 3
TrkA 85 6
VEGFR1 48 1
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 78 9
MKK2 100 11
MKK6 112 6
ERK1 80 6
ERK2 80 9
JNK1 98 5
JNK2 107 0
JNK3 93 7
p38 alpha MAPK 102 12
p38 beta MAPK 68 2
p38 gamma MAPK 96 0
p38 delta MAPK 92 5
ERK8 11 0
RSK1 15 0
RSK2 29 1
PDK1 78 7
PKB alpha 83 4
PKB beta 17 1
SGK1 79 1
S6K1 30 3
PKA 85 1
ROCK 2 50 4
PRK2 65 0
PKC alpha 43 2
PKC zeta 90 11
PKD1 63 12
MSK1 78 6
MNK1 78 11
MNK2 79 8
MAPKAP-K2 94 1
MAPKAP-K3 56 2
PRAK 57 6
CAMKK beta 26 1
CAMK1 24 4
SmMLCK 40 3
PHK 2 0
DAPK1 42 1
CHK1 90 12
CHK2 16 1
GSK3 beta 65 8
CDK2-Cyclin A 59 6
PLK1 97 4
Aurora A 26 5
Aurora B 57 3
LKB1 72 3
AMPK 81 9
MARK1 68 3
MARK2 57 0
MARK3 70 1
MARK4 83 7
BRSK1 75 3
BRSK2 78 8
MELK 38 0
NUAK1 40 3
CK1 delta 96 10
CK2 63 5
DYRK1A 3 0
DYRK2 2 1
DYRK3 4 4
NEK2a 82 7
NEK6 88 12
IKK beta 95 6
IKK epsilon 21 0
TBK1 61 2
PIM1 12 0
PIM2 17 0
PIM3 12 1
SRPK1 39 4
EF2K 89 2
HIPK1 44 2
HIPK2 11 5
HIPK3 35 2
CLK2 7 0
PAK2 69 0
PAK4 61 2
PAK5 63 4
PAK6 99 13
MST2 39 1
MST4 86 2
GCK 7 1
MINK1 12 3
MEKK1 38 3
MLK1 17 1
MLK3 6 0
TAO1 42 2
ASK1 120 4
TAK1 46 1
IRAK4 35 1
RIPK2 10 4
TTK 28 1
Src 78 13
Lck 58 4
CSK 66 4
YES1 31 3
BTK 37 4
JAK2 53 1
SYK 62 1
EPH-A2 72 1
EPH-A4 72 2
EPH-B1 116 8
EPH-B2 83 2
EPH-B3 75 13
EPH-B4 120 1
FGF-R1 31 6
HER4 39 4
IGF-1R 60 8
IR 54 4
IRR 24 0
TrkA 25 3
VEGFR1 18 4

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