Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Compound C (Dorsomorphin) C24H25N5O 399.5 AMPK Yu P.B. (2008) Nat. Chem. Biol. 4 33 Kim E.K. (2004) J. Biol. Chem. 279 19970 WO2008033408A2 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
1µM
10µM
0.1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
CLK2 1 0
ERK8 2 1
CK1 delta 2 0
DYRK1A 2 0
PHK 2 0
MINK1 4 2
DYRK3 5 0
TAK1 5 2
EPH-B4 5 0
GCK 5 2
Lck 5 0
HIPK2 6 1
EPH-B1 6 1
MLK3 7 0
RIPK2 7 2
YES1 8 3
CK2 8 1
CDK2-Cyclin A 8 1
DYRK2 9 0
EPH-A4 10 2
EPH-B2 10 2
EPH-B3 10 0
IRAK4 11 1
FGF-R1 11 2
TrkA 11 5
PRK2 14 4
Src 14 1
VEGFR1 15 0
MSK1 15 1
MELK 16 0
AMPK 16 1
NUAK1 17 3
Aurora B 17 0
CSK 17 1
HIPK1 18 2
ROCK 2 18 4
MNK1 19 4
TBK1 19 1
MARK3 19 0
CAMKK beta 21 2
GSK3 beta 21 1
IRR 21 1
RSK1 22 2
IKK epsilon 22 0
IR 22 3
Aurora A 23 4
SGK1 23 3
MLK1 25 6
MNK2 25 5
BRSK2 27 0
HIPK3 29 2
S6K1 29 1
BTK 30 8
TTK 32 3
DAPK1 33 1
PKB alpha 35 2
BRSK1 36 4
CHK2 36 6
SYK 39 6
EPH-A2 40 1
PKB beta 40 2
PAK4 44 1
PKA 44 2
MARK1 45 1
CHK1 47 1
PIM1 48 5
p38 beta MAPK 50 7
RSK2 50 4
PIM3 52 4
CAMK1 53 0
PKC zeta 53 4
IKK beta 54 3
PKD1 56 12
SmMLCK 56 6
JNK3 56 1
JAK2 57 0
MKK1 57 2
PAK5 57 2
NEK2a 60 6
HER4 61 13
TAO1 62 8
MARK2 62 4
PAK6 63 1
MARK4 63 7
p38 gamma MAPK 67 12
MST4 67 10
MEKK1 67 9
MKK2 71 12
ERK2 71 2
EF2K 72 9
PKC alpha 75 4
IGF-1R 77 11
PRAK 78 10
PLK1 78 1
NEK6 82 3
MST2 83 6
p38 delta MAPK 85 11
LKB1 85 1
MAPKAP-K3 86 15
PAK2 86 3
JNK2 87 7
PDK1 88 7
ASK1 89 2
MAPKAP-K2 90 3
MKK6 96 1
PIM2 96 1
SRPK1 98 3
JNK1 101 1
p38 alpha MAPK 107 12
ERK1 117 13
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
DYRK1A 8 0
ERK8 8 1
CLK2 9 1
RIPK2 9 1
GCK 9 2
CK1 delta 14 0
PHK 15 10
YES1 18 0
VEGFR1 18 3
MINK1 20 0
EPH-B2 21 3
TAK1 21 0
Lck 24 1
TrkA 24 4
CAMKK beta 25 2
EPH-B1 25 1
EPH-B4 26 2
DYRK3 27 0
AMPK 27 1
MELK 27 2
EPH-B3 32 3
HIPK2 32 3
NUAK1 34 13
FGF-R1 36 2
Src 37 1
CDK2-Cyclin A 40 4
IR 40 12
PRK2 40 5
MLK3 42 4
IRAK4 44 2
CK2 45 0
DYRK2 47 0
IRR 47 5
Aurora B 51 8
EPH-A4 52 2
MLK1 53 2
MNK1 56 4
MNK2 56 1
BTK 61 12
TBK1 61 7
HIPK1 64 3
GSK3 beta 65 8
EPH-A2 66 1
IKK epsilon 67 5
MSK1 68 5
CSK 68 5
IKK beta 69 9
S6K1 70 3
MARK1 71 7
MARK3 72 0
MARK2 73 9
MARK4 74 2
PAK4 75 4
RSK1 75 6
CHK2 75 7
ERK2 76 2
EF2K 77 3
p38 beta MAPK 78 3
ROCK 2 80 1
PKB beta 81 11
TTK 83 6
LKB1 83 4
SYK 83 1
BRSK1 83 4
PIM1 84 2
SGK1 84 0
MST2 85 4
TAO1 85 3
PKC zeta 87 3
Aurora A 87 6
PKA 87 2
DAPK1 88 5
PLK1 89 6
MKK2 92 11
JNK3 94 2
HER4 94 4
MAPKAP-K3 94 3
PKB alpha 94 1
CAMK1 94 13
BRSK2 94 7
JNK1 95 3
PKC alpha 96 9
PAK5 96 11
ASK1 96 7
PKD1 97 15
NEK2a 97 1
p38 alpha MAPK 98 7
HIPK3 99 3
p38 delta MAPK 99 13
MEKK1 99 11
NEK6 101 9
MKK1 101 1
p38 gamma MAPK 102 0
IGF-1R 103 14
MKK6 103 2
RSK2 104 7
PIM3 105 11
JAK2 107 12
ERK1 107 8
CHK1 107 6
PIM2 108 4
SRPK1 108 3
PAK6 110 14
MAPKAP-K2 115 8
MST4 115 3
PRAK 117 3
PAK2 118 13
SmMLCK 120 4
JNK2 120 9
PDK1 122 6
Screening Concentration: 0.1µM
Kinase % Activity Remainingsort descending Standard Deviation
VEGFR1 18 0
RIPK2 23 2
GCK 29 4
CLK2 38 0
PHK 43 3
MELK 43 0
DYRK1A 44 0
NUAK1 45 4
IR 46 12
CK1 delta 47 1
ERK8 49 1
YES1 50 3
TrkA 51 2
CAMKK beta 56 0
MINK1 62 7
AMPK 64 7
IRR 69 3
MLK1 70 11
GSK3 beta 70 3
EPH-B1 70 5
TAK1 71 3
CDK2-Cyclin A 71 4
Lck 73 5
DYRK3 74 0
Src 76 5
LKB1 76 13
EPH-B3 78 9
IKK beta 79 1
MARK4 80 3
S6K1 80 0
EPH-B2 80 2
EPH-B4 81 3
EF2K 81 1
MARK2 81 1
CSK 83 6
ERK2 84 10
PRK2 85 12
CK2 85 6
TTK 86 6
PKA 87 0
ASK1 87 0
PAK4 87 8
MKK1 88 6
ROCK 2 88 1
DYRK2 88 0
IKK epsilon 88 5
CHK2 89 4
JNK3 89 12
BTK 89 3
PKB beta 90 6
FGF-R1 90 5
MLK3 90 0
NEK6 90 6
MAPKAP-K3 90 4
BRSK1 91 1
PKC zeta 91 13
MSK1 91 9
EPH-A2 91 8
RSK1 91 2
SYK 92 6
MST2 92 7
HIPK2 93 8
MARK1 94 6
PIM3 95 13
JNK1 95 1
p38 beta MAPK 95 9
PAK6 95 0
PKB alpha 96 2
BRSK2 96 4
HIPK3 96 2
p38 gamma MAPK 96 5
Aurora B 96 10
MKK6 97 10
IGF-1R 98 6
MARK3 99 3
JNK2 99 12
MNK1 99 4
MAPKAP-K2 99 6
MST4 99 6
PIM1 100 7
SGK1 100 2
JAK2 100 3
NEK2a 100 8
TBK1 100 12
MEKK1 101 6
CHK1 101 1
HIPK1 101 0
PKD1 101 3
SRPK1 102 5
PDK1 102 3
PRAK 102 3
IRAK4 103 13
DAPK1 103 1
TAO1 103 11
p38 alpha MAPK 103 5
HER4 104 9
p38 delta MAPK 104 8
PIM2 105 4
PKC alpha 105 12
PLK1 105 11
MKK2 106 1
SmMLCK 106 9
PAK5 108 4
EPH-A4 108 13
RSK2 108 6
PAK2 111 12
MNK2 112 3
CAMK1 117 7
ERK1 117 11
Aurora A 117 3

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