Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Compound C (Dorsomorphin) C24H25N5O 399.5 AMPK Yu P.B. (2008) Nat. Chem. Biol. 4 33 Kim E.K. (2004) J. Biol. Chem. 279 19970 WO2008033408A2 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
1µM
10µM
0.1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 101 1
MKK2 92 11
MKK6 103 2
ERK1 107 8
ERK2 76 2
JNK1 95 3
JNK2 120 9
JNK3 94 2
p38 alpha MAPK 98 7
p38 beta MAPK 78 3
p38 gamma MAPK 102 0
p38 delta MAPK 99 13
ERK8 8 1
RSK1 75 6
RSK2 104 7
PDK1 122 6
PKB alpha 94 1
PKB beta 81 11
SGK1 84 0
S6K1 70 3
PKA 87 2
ROCK 2 80 1
PRK2 40 5
PKC alpha 96 9
PKC zeta 87 3
PKD1 97 15
MSK1 68 5
MNK1 56 4
MNK2 56 1
MAPKAP-K2 115 8
MAPKAP-K3 94 3
PRAK 117 3
CAMKK beta 25 2
CAMK1 94 13
SmMLCK 120 4
PHK 15 10
DAPK1 88 5
CHK1 107 6
CHK2 75 7
GSK3 beta 65 8
CDK2-Cyclin A 40 4
PLK1 89 6
Aurora A 87 6
Aurora B 51 8
LKB1 83 4
AMPK 27 1
MARK1 71 7
MARK2 73 9
MARK3 72 0
MARK4 74 2
BRSK1 83 4
BRSK2 94 7
MELK 27 2
NUAK1 34 13
CK1 delta 14 0
CK2 45 0
DYRK1A 8 0
DYRK2 47 0
DYRK3 27 0
NEK2a 97 1
NEK6 101 9
IKK beta 69 9
IKK epsilon 67 5
TBK1 61 7
PIM1 84 2
PIM2 108 4
PIM3 105 11
SRPK1 108 3
EF2K 77 3
HIPK1 64 3
HIPK2 32 3
HIPK3 99 3
CLK2 9 1
PAK2 118 13
PAK4 75 4
PAK5 96 11
PAK6 110 14
MST2 85 4
MST4 115 3
GCK 9 2
MINK1 20 0
MEKK1 99 11
MLK1 53 2
MLK3 42 4
TAO1 85 3
ASK1 96 7
TAK1 21 0
IRAK4 44 2
RIPK2 9 1
TTK 83 6
Src 37 1
Lck 24 1
CSK 68 5
YES1 18 0
BTK 61 12
JAK2 107 12
SYK 83 1
EPH-A2 66 1
EPH-A4 52 2
EPH-B1 25 1
EPH-B2 21 3
EPH-B3 32 3
EPH-B4 26 2
FGF-R1 36 2
HER4 94 4
IGF-1R 103 14
IR 40 12
IRR 47 5
TrkA 24 4
VEGFR1 18 3
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 88 6
MKK2 106 1
MKK6 97 10
ERK1 117 11
ERK2 84 10
JNK1 95 1
JNK2 99 12
JNK3 89 12
p38 alpha MAPK 103 5
p38 beta MAPK 95 9
p38 gamma MAPK 96 5
p38 delta MAPK 104 8
ERK8 49 1
RSK1 91 2
RSK2 108 6
PDK1 102 3
PKB alpha 96 2
PKB beta 90 6
SGK1 100 2
S6K1 80 0
PKA 87 0
ROCK 2 88 1
PRK2 85 12
PKC alpha 105 12
PKC zeta 91 13
PKD1 101 3
MSK1 91 9
MNK1 99 4
MNK2 112 3
MAPKAP-K2 99 6
MAPKAP-K3 90 4
PRAK 102 3
CAMKK beta 56 0
CAMK1 117 7
SmMLCK 106 9
PHK 43 3
DAPK1 103 1
CHK1 101 1
CHK2 89 4
GSK3 beta 70 3
CDK2-Cyclin A 71 4
PLK1 105 11
Aurora A 117 3
Aurora B 96 10
LKB1 76 13
AMPK 64 7
MARK1 94 6
MARK2 81 1
MARK3 99 3
MARK4 80 3
BRSK1 91 1
BRSK2 96 4
MELK 43 0
NUAK1 45 4
CK1 delta 47 1
CK2 85 6
DYRK1A 44 0
DYRK2 88 0
DYRK3 74 0
NEK2a 100 8
NEK6 90 6
IKK beta 79 1
IKK epsilon 88 5
TBK1 100 12
PIM1 100 7
PIM2 105 4
PIM3 95 13
SRPK1 102 5
EF2K 81 1
HIPK1 101 0
HIPK2 93 8
HIPK3 96 2
CLK2 38 0
PAK2 111 12
PAK4 87 8
PAK5 108 4
PAK6 95 0
MST2 92 7
MST4 99 6
GCK 29 4
MINK1 62 7
MEKK1 101 6
MLK1 70 11
MLK3 90 0
TAO1 103 11
ASK1 87 0
TAK1 71 3
IRAK4 103 13
RIPK2 23 2
TTK 86 6
Src 76 5
Lck 73 5
CSK 83 6
YES1 50 3
BTK 89 3
JAK2 100 3
SYK 92 6
EPH-A2 91 8
EPH-A4 108 13
EPH-B1 70 5
EPH-B2 80 2
EPH-B3 78 9
EPH-B4 81 3
FGF-R1 90 5
HER4 104 9
IGF-1R 98 6
IR 46 12
IRR 69 3
TrkA 51 2
VEGFR1 18 0
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 57 2
MKK2 71 12
MKK6 96 1
ERK1 117 13
ERK2 71 2
JNK1 101 1
JNK2 87 7
JNK3 56 1
p38 alpha MAPK 107 12
p38 beta MAPK 50 7
p38 gamma MAPK 67 12
p38 delta MAPK 85 11
ERK8 2 1
RSK1 22 2
RSK2 50 4
PDK1 88 7
PKB alpha 35 2
PKB beta 40 2
SGK1 23 3
S6K1 29 1
PKA 44 2
ROCK 2 18 4
PRK2 14 4
PKC alpha 75 4
PKC zeta 53 4
PKD1 56 12
MSK1 15 1
MNK1 19 4
MNK2 25 5
MAPKAP-K2 90 3
MAPKAP-K3 86 15
PRAK 78 10
CAMKK beta 21 2
CAMK1 53 0
SmMLCK 56 6
PHK 2 0
DAPK1 33 1
CHK1 47 1
CHK2 36 6
GSK3 beta 21 1
CDK2-Cyclin A 8 1
PLK1 78 1
Aurora A 23 4
Aurora B 17 0
LKB1 85 1
AMPK 16 1
MARK1 45 1
MARK2 62 4
MARK3 19 0
MARK4 63 7
BRSK1 36 4
BRSK2 27 0
MELK 16 0
NUAK1 17 3
CK1 delta 2 0
CK2 8 1
DYRK1A 2 0
DYRK2 9 0
DYRK3 5 0
NEK2a 60 6
NEK6 82 3
IKK beta 54 3
IKK epsilon 22 0
TBK1 19 1
PIM1 48 5
PIM2 96 1
PIM3 52 4
SRPK1 98 3
EF2K 72 9
HIPK1 18 2
HIPK2 6 1
HIPK3 29 2
CLK2 1 0
PAK2 86 3
PAK4 44 1
PAK5 57 2
PAK6 63 1
MST2 83 6
MST4 67 10
GCK 5 2
MINK1 4 2
MEKK1 67 9
MLK1 25 6
MLK3 7 0
TAO1 62 8
ASK1 89 2
TAK1 5 2
IRAK4 11 1
RIPK2 7 2
TTK 32 3
Src 14 1
Lck 5 0
CSK 17 1
YES1 8 3
BTK 30 8
JAK2 57 0
SYK 39 6
EPH-A2 40 1
EPH-A4 10 2
EPH-B1 6 1
EPH-B2 10 2
EPH-B3 10 0
EPH-B4 5 0
FGF-R1 11 2
HER4 61 13
IGF-1R 77 11
IR 22 3
IRR 21 1
TrkA 11 5
VEGFR1 15 0

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