Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
CHIR 99021 (CT 99021) C22H18Cl2N8 465.34 GSK3 Ring D.B. (2003) Diabetes 52 588 WO1999065897 Axon Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remainingsort ascending Standard Deviation
EPH-B3 130 15
FGF-R1 127 42
MAPKAP-K2 110 3
IR 109 7
EPH-A2 106 15
PKB alpha 105 0
p38 gamma MAPK 101 6
BTK 101 6
p38 delta MAPK 100 6
YES1 100 3
EF2K 99 1
TBK1 98 8
SYK 97 20
CHK1 97 2
IRR 95 4
PRK2 93 1
CHK2 93 3
MST4 91 8
MARK3 91 8
PKC zeta 90 1
ERK8 90 1
CAMKK alpha 89 3
HIPK3 89 0
ERK2 89 6
PKA 89 0
NEK6 89 5
RSK2 88 6
Lck 88 3
IKK beta 87 8
p38 beta MAPK 87 3
DYRK2 87 2
JNK2 87 3
VEGFR1 86 3
Aurora B 85 8
MNK2 85 8
AMPK 85 4
PDK1 85 0
CK1 delta 85 3
IKK epsilon 85 1
NEK7 84 0
HIPK2 84 3
CAMKK beta 84 2
S6K1 84 2
PAK6 84 0
JNK1 84 8
MSK1 83 9
CAMK1 83 0
Src 83 1
NEK2a 83 0
p38 alpha MAPK 82 9
Aurora C 82 7
SmMLCK 82 1
MNK1 81 6
SRPK1 81 5
DYRK1A 81 9
PKB beta 80 5
PAK5 80 2
MST2 79 6
ROCK 2 79 3
PKC alpha 78 8
SGK1 78 4
ERK1 77 2
PRAK 76 7
PKD1 75 8
PHK 75 1
PAK4 74 1
CK2 71 2
JNK3 70 3
PIM1 70 1
MAPKAP-K3 70 7
MKK1 70 3
BRSK2 67 1
IGF-1R 66 2
DYRK3 66 2
CSK 66 0
RSK1 65 8
PIM3 64 4
PIM2 63 0
CDK2-Cyclin A 53 3
PLK1 50 1
MELK 45 5
GSK3 beta 1 1
Screening Concentration: 10µM
Kinase % Activity Remainingsort ascending Standard Deviation
PKB alpha 112 0
ERK1 105 0
NEK7 104 2
MAPKAP-K3 103 0
S6K1 101 3
ERK2 97 4
p38 alpha MAPK 93 6
p38 beta MAPK 91 4
ROCK 2 90 0
CHK2 90 2
NEK6 88 1
MAPKAP-K2 88 5
CAMK1 88 2
p38 gamma MAPK 87 6
MNK2 86 5
HIPK3 86 5
RSK2 85 3
EF2K 84 4
PAK6 84 4
PRK2 82 4
MARK3 82 0
PHK 82 1
JNK3 81 0
PDK1 81 7
CHK1 80 5
PAK5 80 2
RSK1 78 1
PAK4 77 1
JNK1 75 7
MKK1 75 3
DYRK2 75 2
PKA 75 3
CSK 74 2
MNK1 74 3
CK2 74 8
PKB beta 73 7
PKC zeta 71 6
CK1 delta 71 8
NEK2a 70 7
SGK1 69 4
HIPK2 68 1
CAMKK beta 68 6
Lck 66 5
JNK2 66 6
p38 delta MAPK 65 4
ERK8 65 5
DYRK3 65 7
SmMLCK 64 7
PIM3 63 0
Aurora C 62 2
SRPK1 62 4
Src 62 1
Aurora B 61 4
PRAK 60 1
PIM1 58 3
BRSK2 58 4
MST2 57 9
IKK beta 55 0
PIM2 54 6
MSK1 50 0
CAMKK alpha 49 7
DYRK1A 47 5
PKD1 46 1
PLK1 37 0
AMPK 36 2
CDK2-Cyclin A 28 4
MELK 16 1
PKC alpha 10 0
GSK3 beta 1 1

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