Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
CHIR 99021 (CT 99021) C22H18Cl2N8 465.34 GSK3 Ring D.B. (2003) Diabetes 52 588 WO1999065897 Axon Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 70 3
ERK1 77 2
ERK2 89 6
JNK1 84 8
JNK2 87 3
JNK3 70 3
p38 alpha MAPK 82 9
p38 beta MAPK 87 3
p38 gamma MAPK 101 6
p38 delta MAPK 100 6
ERK8 90 1
RSK1 65 8
RSK2 88 6
PDK1 85 0
PKB alpha 105 0
PKB beta 80 5
SGK1 78 4
S6K1 84 2
PKA 89 0
ROCK 2 79 3
PRK2 93 1
PKC alpha 78 8
PKC zeta 90 1
PKD1 75 8
MSK1 83 9
MNK1 81 6
MNK2 85 8
MAPKAP-K2 110 3
MAPKAP-K3 70 7
PRAK 76 7
CAMKK alpha 89 3
CAMKK beta 84 2
CAMK1 83 0
SmMLCK 82 1
PHK 75 1
CHK1 97 2
CHK2 93 3
GSK3 beta 1 1
CDK2-Cyclin A 53 3
PLK1 50 1
Aurora B 85 8
Aurora C 82 7
AMPK 85 4
MARK3 91 8
BRSK2 67 1
MELK 45 5
CK1 delta 85 3
CK2 71 2
DYRK1A 81 9
DYRK2 87 2
DYRK3 66 2
NEK2a 83 0
NEK6 89 5
NEK7 84 0
IKK beta 87 8
IKK epsilon 85 1
TBK1 98 8
PIM1 70 1
PIM2 63 0
PIM3 64 4
SRPK1 81 5
EF2K 99 1
HIPK2 84 3
HIPK3 89 0
PAK4 74 1
PAK5 80 2
PAK6 84 0
MST2 79 6
MST4 91 8
Src 83 1
Lck 88 3
CSK 66 0
YES1 100 3
BTK 101 6
SYK 97 20
EPH-A2 106 15
EPH-B3 130 15
FGF-R1 127 42
IGF-1R 66 2
IR 109 7
IRR 95 4
VEGFR1 86 3
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 75 3
ERK1 105 0
ERK2 97 4
JNK1 75 7
JNK2 66 6
JNK3 81 0
p38 alpha MAPK 93 6
p38 beta MAPK 91 4
p38 gamma MAPK 87 6
p38 delta MAPK 65 4
ERK8 65 5
RSK1 78 1
RSK2 85 3
PDK1 81 7
PKB alpha 112 0
PKB beta 73 7
SGK1 69 4
S6K1 101 3
PKA 75 3
ROCK 2 90 0
PRK2 82 4
PKC alpha 10 0
PKC zeta 71 6
PKD1 46 1
MSK1 50 0
MNK1 74 3
MNK2 86 5
MAPKAP-K2 88 5
MAPKAP-K3 103 0
PRAK 60 1
CAMKK alpha 49 7
CAMKK beta 68 6
CAMK1 88 2
SmMLCK 64 7
PHK 82 1
CHK1 80 5
CHK2 90 2
GSK3 beta 1 1
CDK2-Cyclin A 28 4
PLK1 37 0
Aurora B 61 4
Aurora C 62 2
AMPK 36 2
MARK3 82 0
BRSK2 58 4
MELK 16 1
CK1 delta 71 8
CK2 74 8
DYRK1A 47 5
DYRK2 75 2
DYRK3 65 7
NEK2a 70 7
NEK6 88 1
NEK7 104 2
IKK beta 55 0
PIM1 58 3
PIM2 54 6
PIM3 63 0
SRPK1 62 4
EF2K 84 4
HIPK2 68 1
HIPK3 86 5
PAK4 77 1
PAK5 80 2
PAK6 84 4
MST2 57 9
Src 62 1
Lck 66 5
CSK 74 2

Do you need any help? Please get in touch and we’ll be happy to lend a hand.