Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Chelerythrine Chloride C21H18NO4Cl 383.8 PKC Kandasamy R.A. (1995) J. Biol. Chem. 270 29209 Jarvis W.D. (1994) Cancer Res. 54 1707 WO2003077917 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
10µM
1µM
0.1µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remainingsort ascending Standard Deviation
TrkA 144 33
LKB1 125 11
FGF-R1 120 4
PHK 120 2
CAMKK beta 119 0
BTK 119 5
Lck 116 11
MSK1 116 2
PLK1 115 4
PKA 114 6
MNK2 113 31
IR 113 5
BRK 113 5
EPH-A4 113 2
MST2 112 32
MKK6 112 1
EPH-A2 112 6
JNK2 111 10
HER4 110 1
S6K1 110 7
BRSK1 110 5
BRSK2 110 4
CHK1 110 2
TIE2 109 7
SYK 108 9
p38 alpha MAPK 108 7
DYRK2 107 9
EPH-B4 107 2
PDK1 106 6
GCK 106 3
ZAP70 106 48
HIPK2 106 6
ERK8 106 10
ERK1 105 1
MARK4 105 11
PIM3 105 10
JNK3 105 2
RSK1 105 6
MNK1 105 2
IRR 104 6
ERK2 104 12
SmMLCK 104 4
ASK1 104 5
p38 gamma MAPK 104 13
PAK5 104 6
ROCK 2 103 3
CK1 delta 103 5
PKB alpha 102 12
TAO1 102 0
HIPK1 102 1
HIPK3 102 9
CLK2 102 9
Aurora A 102 3
MPSK1 102 10
MAPKAP-K3 101 15
TBK1 101 2
VEGFR1 101 19
MLK3 101 7
DYRK3 101 2
CSK 100 2
JNK1 100 7
MELK 100 33
TTK 100 0
EPH-B2 100 9
Aurora B 100 5
IKK epsilon 99 3
MARK2 99 4
IRAK4 99 4
ABL 98 11
PIM1 98 3
CAMK1 98 1
PIM2 98 2
CK2 98 2
RIPK2 98 5
MARK1 97 8
MST4 97 6
MEKK1 97 3
EPH-B1 97 11
SRPK1 96 0
PKC zeta 96 5
PKD1 96 6
CDK2-Cyclin A 96 2
PAK4 96 2
RSK2 95 1
NEK6 95 13
YES1 95 4
PKC alpha 95 5
PKC gamma 95 6
GSK3 beta 95 2
EPH-B3 95 16
AMPK 94 22
IKK beta 94 2
PKB beta 94 19
SGK1 94 8
MARK3 94 0
DYRK1A 94 1
p38 delta MAPK 94 9
PRAK 93 7
JAK2 93 0
NUAK1 93 6
NEK2a 93 10
MAPKAP-K2 91 12
PAK2 90 12
MLK1 89 2
Src 89 7
EF2K 88 15
p38 beta MAPK 88 6
MKK1 87 0
IGF-1R 87 6
PRK2 86 4
STK33 86 8
PAK6 84 8
MINK1 84 8
DAPK1 83 8
MKK2 79 1
CHK2 76 6
TAK1 76 3
Screening Concentration: 1µM
Kinase % Activity Remainingsort ascending Standard Deviation
TrkA 133 7
MKK6 123 7
LKB1 115 14
MEKK1 113 0
BRSK1 111 11
ASK1 110 9
p38 alpha MAPK 110 6
MSK1 110 1
EPH-A4 109 6
p38 beta MAPK 108 3
IKK epsilon 108 5
ZAP70 107 10
IR 107 9
CDK2-Cyclin A 106 14
EPH-B2 105 4
S6K1 104 7
MNK1 104 2
EPH-B4 104 5
p38 gamma MAPK 103 0
EPH-B1 103 3
CAMKK beta 103 4
JNK2 102 14
CK1 delta 102 13
CLK2 101 6
MNK2 101 9
PKC zeta 100 3
ABL 100 6
MARK4 99 5
JAK2 99 8
EPH-A2 99 3
MPSK1 99 14
MST2 99 0
ERK1 98 11
RIPK2 98 7
RSK1 98 14
SmMLCK 96 1
EF2K 96 11
CHK1 96 5
AMPK 96 5
MARK1 96 2
PIM2 95 6
PHK 95 3
SRPK1 95 1
BRK 95 8
HIPK3 95 7
MAPKAP-K2 95 4
HER4 95 1
DAPK1 94 4
HIPK2 94 12
IRAK4 93 3
PAK2 93 7
MARK2 93 11
PKA 92 15
STK33 92 7
DYRK2 92 1
CHK2 91 11
IRR 91 8
Aurora A 90 0
SGK1 90 5
MARK3 90 6
TAO1 89 5
CK2 89 4
PKB alpha 89 14
SYK 88 7
MELK 88 9
TAK1 88 9
JNK3 87 0
PAK4 87 0
HIPK1 86 1
PKC gamma 86 6
PAK6 86 6
PDK1 86 2
NUAK1 85 16
PRAK 85 10
ERK2 84 0
ROCK 2 84 6
DYRK3 84 5
MAPKAP-K3 84 9
TBK1 84 11
PRK2 83 0
DYRK1A 83 8
Src 83 7
CSK 83 8
MKK2 82 1
CAMK1 81 14
MLK3 81 4
GSK3 beta 81 0
GCK 81 1
JNK1 80 2
p38 delta MAPK 80 2
PIM1 80 15
PIM3 79 7
BRSK2 79 2
MLK1 78 15
BTK 77 1
TTK 76 1
PAK5 76 4
IKK beta 76 5
MKK1 74 0
RSK2 73 3
ERK8 70 7
FGF-R1 70 1
MST4 69 2
YES1 68 1
Aurora B 67 3
PKC alpha 65 13
PKD1 64 4
PLK1 64 2
IGF-1R 62 0
TIE2 60 10
PKB beta 60 7
NEK6 59 2
EPH-B3 57 0
VEGFR1 53 13
Lck 52 9
MINK1 50 3
NEK2a 34 1
Screening Concentration: 10µM
Kinase % Activity Remainingsort ascending Standard Deviation
MST4 129 6
ZAP70 111 4
EPH-B4 110 9
IR 110 5
p38 gamma MAPK 109 9
ERK1 108 4
ASK1 108 3
PKC alpha 107 6
CDK2-Cyclin A 107 9
PKA 106 6
EF2K 106 1
EPH-B2 105 8
EPH-B1 104 6
Lck 103 0
PHK 103 2
GSK3 beta 103 9
EPH-A4 101 6
IGF-1R 101 1
MKK6 100 5
p38 beta MAPK 99 2
PDK1 98 3
ERK2 97 6
CK2 96 6
MNK2 96 5
PAK5 95 0
MARK3 95 2
CHK2 94 4
SGK1 93 5
MPSK1 93 11
CK1 delta 91 1
BRK 91 5
Aurora B 88 4
TAO1 88 3
IRR 87 3
EPH-B3 85 1
CHK1 85 2
MAPKAP-K2 85 6
MARK1 84 4
CSK 84 7
p38 delta MAPK 83 3
MNK1 83 11
PRK2 82 1
MELK 82 5
DAPK1 81 7
JNK2 80 2
S6K1 79 4
STK33 79 1
RIPK2 79 1
PAK2 79 7
EPH-A2 78 4
ABL 78 6
RSK1 77 3
PKB alpha 75 2
MST2 75 0
MARK2 75 7
PIM2 75 5
PAK6 74 8
ROCK 2 74 0
MSK1 74 1
PAK4 74 3
TTK 73 4
MKK2 72 1
SmMLCK 71 5
SRPK1 71 2
p38 alpha MAPK 71 1
TBK1 70 1
MEKK1 70 1
JAK2 70 7
PRAK 69 0
PKC zeta 69 0
NUAK1 69 9
BRSK2 68 8
DYRK1A 68 7
AMPK 67 4
PKD1 67 2
MARK4 66 4
CLK2 66 1
MKK1 65 6
DYRK2 65 1
LKB1 64 1
PIM3 64 4
TAK1 64 6
Aurora A 62 6
CAMKK beta 61 3
JNK3 61 6
HER4 61 3
HIPK1 58 1
JNK1 57 1
PLK1 57 1
PIM1 53 2
TrkA 53 4
PKC gamma 51 2
SYK 48 2
RSK2 47 6
MAPKAP-K3 45 7
YES1 45 8
BRSK1 41 9
Src 40 7
BTK 36 2
HIPK2 32 8
DYRK3 31 1
FGF-R1 29 3
ERK8 28 1
GCK 27 2
IRAK4 27 5
PKB beta 22 2
IKK epsilon 22 1
HIPK3 22 1
IKK beta 20 8
NEK2a 18 0
TIE2 18 1
MLK1 13 1
CAMK1 12 3
NEK6 10 0
VEGFR1 10 3
MINK1 6 0
MLK3 1 0

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