Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Chelerythrine Chloride C21H18NO4Cl 383.8 PKC Kandasamy R.A. (1995) J. Biol. Chem. 270 29209 Jarvis W.D. (1994) Cancer Res. 54 1707 WO2003077917 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
10µM
1µM
0.1µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remainingsort ascending Standard Deviation
TrkA 144 33
LKB1 125 11
PHK 120 2
FGF-R1 120 4
CAMKK beta 119 0
BTK 119 5
MSK1 116 2
Lck 116 11
PLK1 115 4
PKA 114 6
BRK 113 5
EPH-A4 113 2
MNK2 113 31
IR 113 5
EPH-A2 112 6
MST2 112 32
MKK6 112 1
JNK2 111 10
S6K1 110 7
BRSK1 110 5
BRSK2 110 4
CHK1 110 2
HER4 110 1
TIE2 109 7
SYK 108 9
p38 alpha MAPK 108 7
DYRK2 107 9
EPH-B4 107 2
ZAP70 106 48
HIPK2 106 6
ERK8 106 10
PDK1 106 6
GCK 106 3
ERK1 105 1
MARK4 105 11
PIM3 105 10
JNK3 105 2
RSK1 105 6
MNK1 105 2
ERK2 104 12
SmMLCK 104 4
ASK1 104 5
p38 gamma MAPK 104 13
PAK5 104 6
IRR 104 6
ROCK 2 103 3
CK1 delta 103 5
TAO1 102 0
HIPK1 102 1
HIPK3 102 9
CLK2 102 9
Aurora A 102 3
MPSK1 102 10
PKB alpha 102 12
VEGFR1 101 19
MLK3 101 7
DYRK3 101 2
MAPKAP-K3 101 15
TBK1 101 2
JNK1 100 7
MELK 100 33
TTK 100 0
EPH-B2 100 9
Aurora B 100 5
CSK 100 2
IRAK4 99 4
IKK epsilon 99 3
MARK2 99 4
CAMK1 98 1
PIM2 98 2
CK2 98 2
RIPK2 98 5
ABL 98 11
PIM1 98 3
MEKK1 97 3
EPH-B1 97 11
MARK1 97 8
MST4 97 6
SRPK1 96 0
PKC zeta 96 5
PKD1 96 6
CDK2-Cyclin A 96 2
PAK4 96 2
PKC alpha 95 5
PKC gamma 95 6
GSK3 beta 95 2
EPH-B3 95 16
RSK2 95 1
NEK6 95 13
YES1 95 4
DYRK1A 94 1
p38 delta MAPK 94 9
AMPK 94 22
IKK beta 94 2
PKB beta 94 19
SGK1 94 8
MARK3 94 0
JAK2 93 0
NUAK1 93 6
NEK2a 93 10
PRAK 93 7
MAPKAP-K2 91 12
PAK2 90 12
MLK1 89 2
Src 89 7
EF2K 88 15
p38 beta MAPK 88 6
MKK1 87 0
IGF-1R 87 6
PRK2 86 4
STK33 86 8
PAK6 84 8
MINK1 84 8
DAPK1 83 8
MKK2 79 1
CHK2 76 6
TAK1 76 3
Screening Concentration: 1µM
Kinase % Activity Remainingsort ascending Standard Deviation
TrkA 133 7
MKK6 123 7
LKB1 115 14
MEKK1 113 0
BRSK1 111 11
p38 alpha MAPK 110 6
MSK1 110 1
ASK1 110 9
EPH-A4 109 6
p38 beta MAPK 108 3
IKK epsilon 108 5
IR 107 9
ZAP70 107 10
CDK2-Cyclin A 106 14
EPH-B2 105 4
MNK1 104 2
EPH-B4 104 5
S6K1 104 7
p38 gamma MAPK 103 0
EPH-B1 103 3
CAMKK beta 103 4
CK1 delta 102 13
JNK2 102 14
CLK2 101 6
MNK2 101 9
PKC zeta 100 3
ABL 100 6
EPH-A2 99 3
MPSK1 99 14
MST2 99 0
MARK4 99 5
JAK2 99 8
RIPK2 98 7
RSK1 98 14
ERK1 98 11
AMPK 96 5
MARK1 96 2
SmMLCK 96 1
EF2K 96 11
CHK1 96 5
HIPK3 95 7
MAPKAP-K2 95 4
HER4 95 1
PIM2 95 6
PHK 95 3
SRPK1 95 1
BRK 95 8
HIPK2 94 12
DAPK1 94 4
IRAK4 93 3
PAK2 93 7
MARK2 93 11
STK33 92 7
DYRK2 92 1
PKA 92 15
CHK2 91 11
IRR 91 8
Aurora A 90 0
SGK1 90 5
MARK3 90 6
CK2 89 4
PKB alpha 89 14
TAO1 89 5
TAK1 88 9
SYK 88 7
MELK 88 9
PAK4 87 0
JNK3 87 0
PKC gamma 86 6
PAK6 86 6
PDK1 86 2
HIPK1 86 1
PRAK 85 10
NUAK1 85 16
DYRK3 84 5
MAPKAP-K3 84 9
TBK1 84 11
ERK2 84 0
ROCK 2 84 6
DYRK1A 83 8
Src 83 7
CSK 83 8
PRK2 83 0
MKK2 82 1
GSK3 beta 81 0
GCK 81 1
CAMK1 81 14
MLK3 81 4
p38 delta MAPK 80 2
PIM1 80 15
JNK1 80 2
PIM3 79 7
BRSK2 79 2
MLK1 78 15
BTK 77 1
TTK 76 1
PAK5 76 4
IKK beta 76 5
MKK1 74 0
RSK2 73 3
ERK8 70 7
FGF-R1 70 1
MST4 69 2
YES1 68 1
Aurora B 67 3
PKC alpha 65 13
PKD1 64 4
PLK1 64 2
IGF-1R 62 0
PKB beta 60 7
TIE2 60 10
NEK6 59 2
EPH-B3 57 0
VEGFR1 53 13
Lck 52 9
MINK1 50 3
NEK2a 34 1
Screening Concentration: 10µM
Kinase % Activity Remainingsort ascending Standard Deviation
MST4 129 6
ZAP70 111 4
EPH-B4 110 9
IR 110 5
p38 gamma MAPK 109 9
ASK1 108 3
ERK1 108 4
PKC alpha 107 6
CDK2-Cyclin A 107 9
EF2K 106 1
PKA 106 6
EPH-B2 105 8
EPH-B1 104 6
Lck 103 0
PHK 103 2
GSK3 beta 103 9
IGF-1R 101 1
EPH-A4 101 6
MKK6 100 5
p38 beta MAPK 99 2
PDK1 98 3
ERK2 97 6
CK2 96 6
MNK2 96 5
MARK3 95 2
PAK5 95 0
CHK2 94 4
MPSK1 93 11
SGK1 93 5
CK1 delta 91 1
BRK 91 5
TAO1 88 3
Aurora B 88 4
IRR 87 3
CHK1 85 2
MAPKAP-K2 85 6
EPH-B3 85 1
CSK 84 7
MARK1 84 4
p38 delta MAPK 83 3
MNK1 83 11
PRK2 82 1
MELK 82 5
DAPK1 81 7
JNK2 80 2
STK33 79 1
RIPK2 79 1
PAK2 79 7
S6K1 79 4
ABL 78 6
EPH-A2 78 4
RSK1 77 3
PIM2 75 5
PKB alpha 75 2
MST2 75 0
MARK2 75 7
ROCK 2 74 0
MSK1 74 1
PAK4 74 3
PAK6 74 8
TTK 73 4
MKK2 72 1
SRPK1 71 2
p38 alpha MAPK 71 1
SmMLCK 71 5
MEKK1 70 1
JAK2 70 7
TBK1 70 1
PKC zeta 69 0
NUAK1 69 9
PRAK 69 0
BRSK2 68 8
DYRK1A 68 7
PKD1 67 2
AMPK 67 4
MARK4 66 4
CLK2 66 1
DYRK2 65 1
MKK1 65 6
PIM3 64 4
TAK1 64 6
LKB1 64 1
Aurora A 62 6
JNK3 61 6
HER4 61 3
CAMKK beta 61 3
HIPK1 58 1
JNK1 57 1
PLK1 57 1
PIM1 53 2
TrkA 53 4
PKC gamma 51 2
SYK 48 2
RSK2 47 6
YES1 45 8
MAPKAP-K3 45 7
BRSK1 41 9
Src 40 7
BTK 36 2
HIPK2 32 8
DYRK3 31 1
FGF-R1 29 3
ERK8 28 1
IRAK4 27 5
GCK 27 2
HIPK3 22 1
PKB beta 22 2
IKK epsilon 22 1
IKK beta 20 8
TIE2 18 1
NEK2a 18 0
MLK1 13 1
CAMK1 12 3
VEGFR1 10 3
NEK6 10 0
MINK1 6 0
MLK3 1 0

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