Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Chelerythrine Chloride C21H18NO4Cl 383.8 PKC Kandasamy R.A. (1995) J. Biol. Chem. 270 29209 Jarvis W.D. (1994) Cancer Res. 54 1707 WO2003077917 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
10µM
1µM
0.1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
MLK3 1 0
MINK1 6 0
NEK6 10 0
VEGFR1 10 3
CAMK1 12 3
MLK1 13 1
NEK2a 18 0
TIE2 18 1
IKK beta 20 8
PKB beta 22 2
IKK epsilon 22 1
HIPK3 22 1
GCK 27 2
IRAK4 27 5
ERK8 28 1
FGF-R1 29 3
DYRK3 31 1
HIPK2 32 8
BTK 36 2
Src 40 7
BRSK1 41 9
MAPKAP-K3 45 7
YES1 45 8
RSK2 47 6
SYK 48 2
PKC gamma 51 2
PIM1 53 2
TrkA 53 4
JNK1 57 1
PLK1 57 1
HIPK1 58 1
CAMKK beta 61 3
JNK3 61 6
HER4 61 3
Aurora A 62 6
LKB1 64 1
PIM3 64 4
TAK1 64 6
MKK1 65 6
DYRK2 65 1
MARK4 66 4
CLK2 66 1
AMPK 67 4
PKD1 67 2
BRSK2 68 8
DYRK1A 68 7
PRAK 69 0
PKC zeta 69 0
NUAK1 69 9
TBK1 70 1
MEKK1 70 1
JAK2 70 7
SmMLCK 71 5
SRPK1 71 2
p38 alpha MAPK 71 1
MKK2 72 1
TTK 73 4
PAK6 74 8
ROCK 2 74 0
MSK1 74 1
PAK4 74 3
PKB alpha 75 2
MST2 75 0
MARK2 75 7
PIM2 75 5
RSK1 77 3
EPH-A2 78 4
ABL 78 6
S6K1 79 4
STK33 79 1
RIPK2 79 1
PAK2 79 7
JNK2 80 2
DAPK1 81 7
PRK2 82 1
MELK 82 5
p38 delta MAPK 83 3
MNK1 83 11
MARK1 84 4
CSK 84 7
EPH-B3 85 1
CHK1 85 2
MAPKAP-K2 85 6
IRR 87 3
Aurora B 88 4
TAO1 88 3
CK1 delta 91 1
BRK 91 5
SGK1 93 5
MPSK1 93 11
CHK2 94 4
PAK5 95 0
MARK3 95 2
CK2 96 6
MNK2 96 5
ERK2 97 6
PDK1 98 3
p38 beta MAPK 99 2
MKK6 100 5
EPH-A4 101 6
IGF-1R 101 1
Lck 103 0
PHK 103 2
GSK3 beta 103 9
EPH-B1 104 6
EPH-B2 105 8
PKA 106 6
EF2K 106 1
PKC alpha 107 6
CDK2-Cyclin A 107 9
ERK1 108 4
ASK1 108 3
p38 gamma MAPK 109 9
EPH-B4 110 9
IR 110 5
ZAP70 111 4
MST4 129 6
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
NEK2a 34 1
MINK1 50 3
Lck 52 9
VEGFR1 53 13
EPH-B3 57 0
NEK6 59 2
TIE2 60 10
PKB beta 60 7
IGF-1R 62 0
PKD1 64 4
PLK1 64 2
PKC alpha 65 13
Aurora B 67 3
YES1 68 1
MST4 69 2
ERK8 70 7
FGF-R1 70 1
RSK2 73 3
MKK1 74 0
TTK 76 1
PAK5 76 4
IKK beta 76 5
BTK 77 1
MLK1 78 15
PIM3 79 7
BRSK2 79 2
JNK1 80 2
p38 delta MAPK 80 2
PIM1 80 15
CAMK1 81 14
MLK3 81 4
GSK3 beta 81 0
GCK 81 1
MKK2 82 1
PRK2 83 0
DYRK1A 83 8
Src 83 7
CSK 83 8
ERK2 84 0
ROCK 2 84 6
DYRK3 84 5
MAPKAP-K3 84 9
TBK1 84 11
NUAK1 85 16
PRAK 85 10
HIPK1 86 1
PKC gamma 86 6
PAK6 86 6
PDK1 86 2
JNK3 87 0
PAK4 87 0
SYK 88 7
MELK 88 9
TAK1 88 9
TAO1 89 5
CK2 89 4
PKB alpha 89 14
Aurora A 90 0
SGK1 90 5
MARK3 90 6
CHK2 91 11
IRR 91 8
PKA 92 15
STK33 92 7
DYRK2 92 1
IRAK4 93 3
PAK2 93 7
MARK2 93 11
DAPK1 94 4
HIPK2 94 12
PIM2 95 6
PHK 95 3
SRPK1 95 1
BRK 95 8
HIPK3 95 7
MAPKAP-K2 95 4
HER4 95 1
SmMLCK 96 1
EF2K 96 11
CHK1 96 5
AMPK 96 5
MARK1 96 2
ERK1 98 11
RIPK2 98 7
RSK1 98 14
MARK4 99 5
JAK2 99 8
EPH-A2 99 3
MPSK1 99 14
MST2 99 0
PKC zeta 100 3
ABL 100 6
CLK2 101 6
MNK2 101 9
JNK2 102 14
CK1 delta 102 13
p38 gamma MAPK 103 0
EPH-B1 103 3
CAMKK beta 103 4
S6K1 104 7
MNK1 104 2
EPH-B4 104 5
EPH-B2 105 4
CDK2-Cyclin A 106 14
ZAP70 107 10
IR 107 9
p38 beta MAPK 108 3
IKK epsilon 108 5
EPH-A4 109 6
ASK1 110 9
p38 alpha MAPK 110 6
MSK1 110 1
BRSK1 111 11
MEKK1 113 0
LKB1 115 14
MKK6 123 7
TrkA 133 7
Screening Concentration: 0.1µM
Kinase % Activity Remainingsort descending Standard Deviation
CHK2 76 6
TAK1 76 3
MKK2 79 1
DAPK1 83 8
PAK6 84 8
MINK1 84 8
PRK2 86 4
STK33 86 8
MKK1 87 0
IGF-1R 87 6
EF2K 88 15
p38 beta MAPK 88 6
MLK1 89 2
Src 89 7
PAK2 90 12
MAPKAP-K2 91 12
PRAK 93 7
JAK2 93 0
NUAK1 93 6
NEK2a 93 10
AMPK 94 22
IKK beta 94 2
PKB beta 94 19
SGK1 94 8
MARK3 94 0
DYRK1A 94 1
p38 delta MAPK 94 9
RSK2 95 1
NEK6 95 13
YES1 95 4
PKC alpha 95 5
PKC gamma 95 6
GSK3 beta 95 2
EPH-B3 95 16
SRPK1 96 0
PKC zeta 96 5
PKD1 96 6
CDK2-Cyclin A 96 2
PAK4 96 2
MARK1 97 8
MST4 97 6
MEKK1 97 3
EPH-B1 97 11
ABL 98 11
PIM1 98 3
CAMK1 98 1
PIM2 98 2
CK2 98 2
RIPK2 98 5
IKK epsilon 99 3
MARK2 99 4
IRAK4 99 4
CSK 100 2
JNK1 100 7
MELK 100 33
TTK 100 0
EPH-B2 100 9
Aurora B 100 5
MAPKAP-K3 101 15
TBK1 101 2
VEGFR1 101 19
MLK3 101 7
DYRK3 101 2
PKB alpha 102 12
TAO1 102 0
HIPK1 102 1
HIPK3 102 9
CLK2 102 9
Aurora A 102 3
MPSK1 102 10
ROCK 2 103 3
CK1 delta 103 5
IRR 104 6
ERK2 104 12
SmMLCK 104 4
ASK1 104 5
p38 gamma MAPK 104 13
PAK5 104 6
ERK1 105 1
MARK4 105 11
PIM3 105 10
JNK3 105 2
RSK1 105 6
MNK1 105 2
PDK1 106 6
GCK 106 3
ZAP70 106 48
HIPK2 106 6
ERK8 106 10
DYRK2 107 9
EPH-B4 107 2
SYK 108 9
p38 alpha MAPK 108 7
TIE2 109 7
HER4 110 1
S6K1 110 7
BRSK1 110 5
BRSK2 110 4
CHK1 110 2
JNK2 111 10
MST2 112 32
MKK6 112 1
EPH-A2 112 6
MNK2 113 31
IR 113 5
BRK 113 5
EPH-A4 113 2
PKA 114 6
PLK1 115 4
Lck 116 11
MSK1 116 2
CAMKK beta 119 0
BTK 119 5
FGF-R1 120 4
PHK 120 2
LKB1 125 11
TrkA 144 33

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