Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Chelerythrine Chloride C21H18NO4Cl 383.8 PKC Kandasamy R.A. (1995) J. Biol. Chem. 270 29209 Jarvis W.D. (1994) Cancer Res. 54 1707 WO2003077917 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
10µM
1µM
0.1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 74 0
MKK2 82 1
MKK6 123 7
ERK1 98 11
ERK2 84 0
JNK1 80 2
JNK2 102 14
JNK3 87 0
p38 alpha MAPK 110 6
p38 beta MAPK 108 3
p38 gamma MAPK 103 0
p38 delta MAPK 80 2
ERK8 70 7
RSK1 98 14
RSK2 73 3
PDK1 86 2
PKB alpha 89 14
PKB beta 60 7
SGK1 90 5
S6K1 104 7
PKA 92 15
ROCK 2 84 6
PRK2 83 0
PKC alpha 65 13
PKC gamma 86 6
PKC zeta 100 3
PKD1 64 4
STK33 92 7
MSK1 110 1
MNK1 104 2
MNK2 101 9
MAPKAP-K2 95 4
MAPKAP-K3 84 9
PRAK 85 10
CAMKK beta 103 4
CAMK1 81 14
SmMLCK 96 1
PHK 95 3
DAPK1 94 4
CHK1 96 5
CHK2 91 11
GSK3 beta 81 0
CDK2-Cyclin A 106 14
PLK1 64 2
Aurora A 90 0
Aurora B 67 3
LKB1 115 14
AMPK 96 5
MARK1 96 2
MARK2 93 11
MARK3 90 6
MARK4 99 5
BRSK1 111 11
BRSK2 79 2
MELK 88 9
NUAK1 85 16
CK1 delta 102 13
CK2 89 4
DYRK1A 83 8
DYRK2 92 1
DYRK3 84 5
NEK2a 34 1
NEK6 59 2
IKK beta 76 5
IKK epsilon 108 5
TBK1 84 11
PIM1 80 15
PIM2 95 6
PIM3 79 7
SRPK1 95 1
EF2K 96 11
HIPK1 86 1
HIPK2 94 12
HIPK3 95 7
CLK2 101 6
PAK2 93 7
PAK4 87 0
PAK5 76 4
PAK6 86 6
MST2 99 0
MST4 69 2
GCK 81 1
MINK1 50 3
MEKK1 113 0
MLK1 78 15
MLK3 81 4
TAO1 89 5
ASK1 110 9
TAK1 88 9
IRAK4 93 3
RIPK2 98 7
TTK 76 1
MPSK1 99 14
Src 83 7
Lck 52 9
CSK 83 8
YES1 68 1
ABL 100 6
BTK 77 1
JAK2 99 8
SYK 88 7
ZAP70 107 10
TIE2 60 10
BRK 95 8
EPH-A2 99 3
EPH-A4 109 6
EPH-B1 103 3
EPH-B2 105 4
EPH-B3 57 0
EPH-B4 104 5
FGF-R1 70 1
HER4 95 1
IGF-1R 62 0
IR 107 9
IRR 91 8
TrkA 133 7
VEGFR1 53 13
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 65 6
MKK2 72 1
MKK6 100 5
ERK1 108 4
ERK2 97 6
JNK1 57 1
JNK2 80 2
JNK3 61 6
p38 alpha MAPK 71 1
p38 beta MAPK 99 2
p38 gamma MAPK 109 9
p38 delta MAPK 83 3
ERK8 28 1
RSK1 77 3
RSK2 47 6
PDK1 98 3
PKB alpha 75 2
PKB beta 22 2
SGK1 93 5
S6K1 79 4
PKA 106 6
ROCK 2 74 0
PRK2 82 1
PKC alpha 107 6
PKC gamma 51 2
PKC zeta 69 0
PKD1 67 2
STK33 79 1
MSK1 74 1
MNK1 83 11
MNK2 96 5
MAPKAP-K2 85 6
MAPKAP-K3 45 7
PRAK 69 0
CAMKK beta 61 3
CAMK1 12 3
SmMLCK 71 5
PHK 103 2
DAPK1 81 7
CHK1 85 2
CHK2 94 4
GSK3 beta 103 9
CDK2-Cyclin A 107 9
PLK1 57 1
Aurora A 62 6
Aurora B 88 4
LKB1 64 1
AMPK 67 4
MARK1 84 4
MARK2 75 7
MARK3 95 2
MARK4 66 4
BRSK1 41 9
BRSK2 68 8
MELK 82 5
NUAK1 69 9
CK1 delta 91 1
CK2 96 6
DYRK1A 68 7
DYRK2 65 1
DYRK3 31 1
NEK2a 18 0
NEK6 10 0
IKK beta 20 8
IKK epsilon 22 1
TBK1 70 1
PIM1 53 2
PIM2 75 5
PIM3 64 4
SRPK1 71 2
EF2K 106 1
HIPK1 58 1
HIPK2 32 8
HIPK3 22 1
CLK2 66 1
PAK2 79 7
PAK4 74 3
PAK5 95 0
PAK6 74 8
MST2 75 0
MST4 129 6
GCK 27 2
MINK1 6 0
MEKK1 70 1
MLK1 13 1
MLK3 1 0
TAO1 88 3
ASK1 108 3
TAK1 64 6
IRAK4 27 5
RIPK2 79 1
TTK 73 4
MPSK1 93 11
Src 40 7
Lck 103 0
CSK 84 7
YES1 45 8
ABL 78 6
BTK 36 2
JAK2 70 7
SYK 48 2
ZAP70 111 4
TIE2 18 1
BRK 91 5
EPH-A2 78 4
EPH-A4 101 6
EPH-B1 104 6
EPH-B2 105 8
EPH-B3 85 1
EPH-B4 110 9
FGF-R1 29 3
HER4 61 3
IGF-1R 101 1
IR 110 5
IRR 87 3
TrkA 53 4
VEGFR1 10 3
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 87 0
MKK2 79 1
MKK6 112 1
ERK1 105 1
ERK2 104 12
JNK1 100 7
JNK2 111 10
JNK3 105 2
p38 alpha MAPK 108 7
p38 beta MAPK 88 6
p38 gamma MAPK 104 13
p38 delta MAPK 94 9
ERK8 106 10
RSK1 105 6
RSK2 95 1
PDK1 106 6
PKB alpha 102 12
PKB beta 94 19
SGK1 94 8
S6K1 110 7
PKA 114 6
ROCK 2 103 3
PRK2 86 4
PKC alpha 95 5
PKC gamma 95 6
PKC zeta 96 5
PKD1 96 6
STK33 86 8
MSK1 116 2
MNK1 105 2
MNK2 113 31
MAPKAP-K2 91 12
MAPKAP-K3 101 15
PRAK 93 7
CAMKK beta 119 0
CAMK1 98 1
SmMLCK 104 4
PHK 120 2
DAPK1 83 8
CHK1 110 2
CHK2 76 6
GSK3 beta 95 2
CDK2-Cyclin A 96 2
PLK1 115 4
Aurora A 102 3
Aurora B 100 5
LKB1 125 11
AMPK 94 22
MARK1 97 8
MARK2 99 4
MARK3 94 0
MARK4 105 11
BRSK1 110 5
BRSK2 110 4
MELK 100 33
NUAK1 93 6
CK1 delta 103 5
CK2 98 2
DYRK1A 94 1
DYRK2 107 9
DYRK3 101 2
NEK2a 93 10
NEK6 95 13
IKK beta 94 2
IKK epsilon 99 3
TBK1 101 2
PIM1 98 3
PIM2 98 2
PIM3 105 10
SRPK1 96 0
EF2K 88 15
HIPK1 102 1
HIPK2 106 6
HIPK3 102 9
CLK2 102 9
PAK2 90 12
PAK4 96 2
PAK5 104 6
PAK6 84 8
MST2 112 32
MST4 97 6
GCK 106 3
MINK1 84 8
MEKK1 97 3
MLK1 89 2
MLK3 101 7
TAO1 102 0
ASK1 104 5
TAK1 76 3
IRAK4 99 4
RIPK2 98 5
TTK 100 0
MPSK1 102 10
Src 89 7
Lck 116 11
CSK 100 2
YES1 95 4
ABL 98 11
BTK 119 5
JAK2 93 0
SYK 108 9
ZAP70 106 48
TIE2 109 7
BRK 113 5
EPH-A2 112 6
EPH-A4 113 2
EPH-B1 97 11
EPH-B2 100 9
EPH-B3 95 16
EPH-B4 107 2
FGF-R1 120 4
HER4 110 1
IGF-1R 87 6
IR 113 5
IRR 104 6
TrkA 144 33
VEGFR1 101 19

Do you need any help? Please get in touch and we’ll be happy to lend a hand.