Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
BX-795 C23H26IN7O2S 591.47 PDK1 Feldman R.I. (2005) Journal of Biological Chemistry 280 19867-19874 WO2004048343 Axon Download

Results as Barchart

View results as a bar chart
0.01µM
10µM
0.1µM
1µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 64 16
ERK1 95 13
ERK2 91 3
JNK1 100 3
JNK2 98 5
JNK3 93 3
p38 alpha MAPK 104 10
p38 beta MAPK 71 1
p38 gamma MAPK 97 7
p38 delta MAPK 102 11
ERK8 72 58
RSK1 83 5
RSK2 102 17
PDK1 9 2
PKB alpha 117 11
PKB beta 104 1
SGK1 95 4
S6K1 89 1
PKA 96 0
ROCK 2 58 7
PRK2 58 3
PKC alpha 87 8
PKC zeta 96 0
PKD1 78 0
MSK1 84 5
MNK1 60 0
MNK2 18 7
MAPKAP-K2 108 2
MAPKAP-K3 99 2
PRAK 106 3
CAMKK beta 30 1
CAMK1 107 10
SmMLCK 93 4
PHK 71 2
DAPK1 87 4
CHK1 57 5
CHK2 74 5
GSK3 beta 71 4
CDK2-Cyclin A 19 6
PLK1 95 2
Aurora A 20 2
Aurora B 5 0
LKB1 120 4
AMPK 23 2
MARK1 13 2
MARK2 10 1
MARK3 6 1
MARK4 15 3
BRSK1 77 21
BRSK2 78 5
MELK 57 3
NUAK1 7 4
CK1 delta 106 21
CK2 99 9
DYRK1A 91 2
DYRK2 81 5
DYRK3 82 5
NEK2a 100 11
NEK6 106 12
IKK beta 106 0
IKK epsilon 9 0
TBK1 9 4
PIM1 107 4
PIM2 98 9
PIM3 99 1
SRPK1 108 4
EF2K 113 3
HIPK1 105 3
HIPK2 87 8
HIPK3 103 4
CLK2 65 8
PAK2 106 3
PAK4 97 8
PAK5 100 8
PAK6 114 4
MST2 106 6
MST4 145 12
GCK 21 5
MINK1 105 6
MEKK1 78 3
MLK1 17 2
MLK3 11 0
TAK1 8 1
IRAK4 76 7
RIPK2 105 3
TTK 89 5
Src 98 6
Lck 104 4
CSK 91 6
YES1 117 0
BTK 100 15
JAK2 7 0
SYK 91 12
EPH-A2 79 12
EPH-A4 100 9
EPH-B2 112 5
EPH-B3 100 2
EPH-B4 94 5
FGF-R1 46 3
HER4 98 1
IGF-1R 111 15
IR 103 17
IRR 57 3
TrkA 52 2
VEGFR1 37 1
Screening Concentration: 0.01µM
Kinase % Activity Remaining Standard Deviation
MKK1 49 3
ERK1 81 8
ERK2 88 3
JNK1 103 6
JNK2 100 12
JNK3 93 3
p38 alpha MAPK 85 2
p38 beta MAPK 93 13
p38 gamma MAPK 94 2
p38 delta MAPK 90 5
ERK8 40 3
RSK1 100 6
RSK2 100 9
PDK1 29 2
PKB alpha 90 14
PKB beta 112 6
SGK1 86 6
S6K1 100 3
PKA 101 1
ROCK 2 90 6
PRK2 79 4
PKC alpha 105 1
PKC zeta 95 11
PKD1 83 3
MSK1 88 0
MNK1 80 7
MNK2 46 3
MAPKAP-K2 107 8
MAPKAP-K3 102 6
PRAK 96 5
CAMKK alpha 85 13
CAMKK beta 82 5
CAMK1 86 10
SmMLCK 110 5
PHK 94 12
CHK1 83 5
CHK2 90 0
GSK3 beta 82 14
CDK2-Cyclin A 56 6
PLK1 94 6
Aurora B 17 1
Aurora C 26 3
AMPK 51 0
MARK3 12 0
BRSK2 91 3
MELK 95 3
CK1 delta 78 4
CK2 93 10
DYRK1A 94 7
DYRK2 104 9
DYRK3 85 9
NEK2a 91 6
NEK6 95 3
NEK7 110 7
IKK beta 108 2
IKK epsilon 40 6
TBK1 25 2
PIM1 102 7
PIM2 108 2
PIM3 95 7
SRPK1 98 11
EF2K 97 5
HIPK2 95 11
HIPK3 94 1
PAK4 90 14
PAK5 97 2
PAK6 91 2
MST2 95 2
MST4 126 11
Src 90 4
Lck 97 3
CSK 113 11
YES1 90 6
BTK 107 4
SYK 89 9
EPH-A2 109 7
EPH-B3 110 6
FGF-R1 84 11
IGF-1R 108 8
IR 85 13
IRR 89 0
VEGFR1 75 10
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 2 0
ERK1 5 0
ERK2 6 0
JNK1 16 1
JNK2 17 5
JNK3 38 0
p38 alpha MAPK 87 10
p38 beta MAPK 60 3
p38 gamma MAPK 17 3
p38 delta MAPK 27 1
ERK8 2 1
RSK1 4 1
RSK2 11 0
PDK1 1 0
PKB alpha 46 7
PKB beta 55 11
SGK1 8 0
S6K1 6 0
PKA 10 0
ROCK 2 2 0
PRK2 1 7
PKC alpha 10 0
PKC zeta 66 7
PKD1 2 0
MSK1 25 4
MNK1 1 0
MNK2 6 8
MAPKAP-K2 70 8
MAPKAP-K3 80 1
PRAK 43 0
CAMKK beta 10 1
CAMK1 12 2
SmMLCK 84 10
PHK 2 1
CHK1 2 0
CHK2 2 0
GSK3 beta 3 0
CDK2-Cyclin A 0 0
PLK1 55 0
Aurora B 1 0
Aurora C 2 2
AMPK 1 0
MARK3 2 2
BRSK2 0 0
MELK 4 1
CK1 delta 83 3
CK2 38 5
DYRK1A 35 16
DYRK2 7 0
DYRK3 4 7
NEK2a 7 0
NEK6 63 8
NEK7 84 9
IKK beta 41 1
IKK epsilon 0 0
TBK1 2 0
PIM1 53 0
PIM2 75 9
PIM3 18 6
SRPK1 79 15
EF2K 74 1
HIPK2 14 0
HIPK3 33 2
PAK4 6 4
PAK5 15 4
PAK6 16 3
MST2 15 2
MST4 13 1
Src 10 0
Lck 14 0
CSK 69 3
YES1 11 1
SYK 6 4
EPH-A2 66 6
FGF-R1 2 0
IRR 10 0
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 21 1
ERK1 48 9
ERK2 46 1
JNK1 69 2
JNK2 57 4
JNK3 68 6
p38 alpha MAPK 108 4
p38 beta MAPK 89 1
p38 gamma MAPK 61 2
p38 delta MAPK 58 5
ERK8 16 3
RSK1 28 1
RSK2 42 5
PDK1 3 0
PKB alpha 93 2
PKB beta 95 1
SGK1 42 2
S6K1 37 2
PKA 64 4
ROCK 2 10 2
PRK2 18 1
PKC alpha 50 12
PKC zeta 90 1
PKD1 22 1
MSK1 60 6
MNK1 18 0
MNK2 15 8
MAPKAP-K2 88 8
MAPKAP-K3 93 5
PRAK 91 14
CAMKK beta 13 0
CAMK1 79 2
SmMLCK 92 1
PHK 27 2
DAPK1 38 5
CHK1 19 1
CHK2 20 1
GSK3 beta 17 3
CDK2-Cyclin A 5 4
PLK1 93 7
Aurora A 2 0
Aurora B 3 1
LKB1 63 8
AMPK 3 0
MARK1 8 1
MARK2 5 1
MARK3 3 1
MARK4 9 0
BRSK1 34 0
BRSK2 31 4
MELK 11 1
NUAK1 7 0
CK1 delta 93 3
CK2 87 1
DYRK1A 58 1
DYRK2 28 1
DYRK3 24 2
NEK2a 64 4
NEK6 80 10
IKK beta 82 4
IKK epsilon 5 0
TBK1 6 2
PIM1 92 4
PIM2 92 8
PIM3 74 2
SRPK1 101 0
EF2K 99 2
HIPK1 82 6
HIPK2 59 0
HIPK3 76 7
CLK2 13 1
PAK2 94 2
PAK4 40 1
PAK5 66 3
PAK6 87 10
MST2 64 8
MST4 111 1
GCK 10 2
MINK1 70 2
MEKK1 32 2
MLK1 5 1
MLK3 2 0
TAK1 1 0
IRAK4 22 1
RIPK2 77 1
TTK 53 14
Src 64 4
Lck 66 0
CSK 65 6
YES1 66 4
BTK 61 10
JAK2 2 1
SYK 35 3
EPH-A2 70 2
EPH-A4 82 1
EPH-B2 100 2
EPH-B3 115 37
EPH-B4 94 16
FGF-R1 12 0
HER4 82 2
IGF-1R 85 13
IR 77 1
IRR 28 1
TrkA 28 2
VEGFR1 8 1

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