Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
BX-517 Analog (compound 7b) C19H15N5O2 345.35 PDK1 Islam I. (2007) Bioorganic and Medicinal Chemistry Letters 17 3819-3825 Download

Results as Barchart

View results as a bar chart
0.1µM
1µM
10µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remainingsort ascending Standard Deviation
JNK2 214 172
JNK1 124 1
IR 112 14
CAMK1 112 12
EPH-B3 107 1
PKC alpha 106 3
ROCK 2 103 25
p38 beta MAPK 103 0
EF2K 102 14
NEK2a 100 10
MSK1 98 1
CSK 98 0
SYK 95 23
PRAK 95 6
p38 gamma MAPK 93 6
CK2 93 17
EPH-A2 93 0
NEK6 92 6
SRPK1 90 4
CK1 delta 90 0
PKB beta 88 3
PLK1 86 5
BTK 86 11
MAPKAP-K2 86 3
PAK6 86 1
PKC zeta 85 4
p38 delta MAPK 85 9
PKB alpha 85 4
CHK1 85 2
ERK2 81 10
p38 alpha MAPK 81 8
MNK1 80 0
PKA 78 0
SGK1 77 5
PIM2 76 6
S6K1 76 0
MNK2 75 12
PAK5 75 10
IKK beta 75 1
ERK1 71 7
CAMKK beta 67 7
PAK4 64 5
CDK2-Cyclin A 63 0
MST4 55 32
SmMLCK 54 7
IKK epsilon 51 14
IGF-1R 49 49
Lck 44 4
PIM1 43 2
DYRK1A 42 9
Src 41 2
RSK2 38 4
IRR 35 0
HIPK2 33 1
YES1 32 4
PIM3 30 0
PKD1 30 2
TBK1 27 17
PRK2 25 11
RSK1 24 4
PDK1 20 1
DYRK2 19 3
DYRK3 19 3
FGF-R1 17 3
MARK3 16 3
MELK 16 0
BRSK2 13 3
PHK 13 0
GSK3 beta 11 1
MST2 8 0
MKK1 8 1
VEGFR1 7 0
AMPK 5 0
ERK8 5 0
CHK2 -1 0
Screening Concentration: 10µM
Kinase % Activity Remainingsort ascending Standard Deviation
EF2K 116 7
p38 gamma MAPK 75 27
PKB alpha 62 7
EPH-B3 53 8
p38 beta MAPK 49 9
JNK1 48 4
p38 alpha MAPK 45 6
CSK 42 6
NEK6 38 2
PAK6 38 4
PKB beta 36 4
SRPK1 36 3
CAMKK beta 35 3
PKA 32 5
MSK1 30 0
MNK1 30 14
PAK4 29 31
NEK2a 28 1
PKC alpha 27 7
DYRK1A 27 33
IKK beta 26 4
IR 26 6
p38 delta MAPK 22 1
RSK2 22 3
MST4 21 6
PKC zeta 21 4
CK2 21 1
EPH-A2 20 1
CK1 delta 20 5
CAMK1 19 0
PLK1 18 6
BRSK2 18 3
JNK2 17 0
ERK2 16 3
MNK2 16 2
S6K1 12 1
IKK epsilon 11 6
TBK1 11 9
MAPKAP-K2 10 6
BTK 9 6
PIM2 8 0
PAK5 8 0
PRAK 8 1
ROCK 2 7 1
SYK 7 0
PIM3 7 2
SGK1 6 2
PRK2 6 0
CDK2-Cyclin A 6 0
IRR 5 2
RSK1 5 0
ERK1 4 0
AMPK 4 1
Lck 3 0
GSK3 beta 3 2
YES1 3 1
PKD1 3 2
MARK3 3 1
MKK1 2 1
PIM1 2 2
DYRK3 1 0
SmMLCK 1 1
FGF-R1 1 0
CHK1 1 0
CHK2 1 4
IGF-1R 1 0
HIPK2 1 0
VEGFR1 1 0
ERK8 1 0
Src 1 0
PDK1 0 2
DYRK2 0 0
PHK 0 0
MST2 0 0
MELK 0 0
Screening Concentration: 1µM
Kinase % Activity Remainingsort ascending Standard Deviation
IR 101 11
JNK1 99 1
EPH-B3 90 11
p38 gamma MAPK 86 4
EF2K 86 3
PKC alpha 83 5
p38 alpha MAPK 80 4
p38 beta MAPK 80 5
PAK6 77 3
PKB beta 77 7
NEK6 76 10
NEK2a 75 2
IKK beta 75 27
SRPK1 75 1
MSK1 73 2
PKB alpha 69 0
CAMK1 69 5
CSK 69 6
PKA 66 0
PKC zeta 66 1
CK2 65 5
p38 delta MAPK 62 1
ERK1 60 52
CK1 delta 59 10
MNK1 54 0
EPH-A2 54 5
PRAK 50 6
MAPKAP-K2 49 6
MNK2 46 5
PAK5 43 0
JNK2 43 0
PLK1 42 4
CAMKK beta 41 12
ERK2 41 9
SYK 40 1
ROCK 2 37 4
PIM2 34 0
IGF-1R 33 7
RSK2 32 14
SGK1 32 0
S6K1 32 0
PAK4 31 0
BTK 29 5
MST4 18 0
IRR 16 5
CDK2-Cyclin A 14 2
IKK epsilon 12 1
DYRK1A 11 6
SmMLCK 11 1
BRSK2 10 3
RSK1 10 4
Lck 10 0
PIM1 9 0
PIM3 9 2
YES1 8 0
HIPK2 7 0
Src 7 0
GSK3 beta 7 3
TBK1 7 6
AMPK 6 4
PRK2 5 3
MARK3 5 1
DYRK3 4 1
CHK1 4 0
VEGFR1 3 1
MELK 3 0
PDK1 3 0
PKD1 3 0
ERK8 2 0
DYRK2 2 0
FGF-R1 2 0
MST2 2 1
PHK 1 0
MKK1 1 0
CHK2 -5 0

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