Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
BX-517 Analog (compound 7b) C19H15N5O2 345.35 PDK1 Islam I. (2007) Bioorganic and Medicinal Chemistry Letters 17 3819-3825 Download

Results as Barchart

View results as a bar chart
0.1µM
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
CHK2 -5 0
PHK 1 0
MKK1 1 0
FGF-R1 2 0
MST2 2 1
ERK8 2 0
DYRK2 2 0
PKD1 3 0
VEGFR1 3 1
MELK 3 0
PDK1 3 0
CHK1 4 0
DYRK3 4 1
PRK2 5 3
MARK3 5 1
AMPK 6 4
GSK3 beta 7 3
TBK1 7 6
HIPK2 7 0
Src 7 0
YES1 8 0
PIM1 9 0
PIM3 9 2
BRSK2 10 3
RSK1 10 4
Lck 10 0
SmMLCK 11 1
DYRK1A 11 6
IKK epsilon 12 1
CDK2-Cyclin A 14 2
IRR 16 5
MST4 18 0
BTK 29 5
PAK4 31 0
SGK1 32 0
S6K1 32 0
RSK2 32 14
IGF-1R 33 7
PIM2 34 0
ROCK 2 37 4
SYK 40 1
ERK2 41 9
CAMKK beta 41 12
PLK1 42 4
JNK2 43 0
PAK5 43 0
MNK2 46 5
MAPKAP-K2 49 6
PRAK 50 6
EPH-A2 54 5
MNK1 54 0
CK1 delta 59 10
ERK1 60 52
p38 delta MAPK 62 1
CK2 65 5
PKA 66 0
PKC zeta 66 1
PKB alpha 69 0
CAMK1 69 5
CSK 69 6
MSK1 73 2
NEK2a 75 2
IKK beta 75 27
SRPK1 75 1
NEK6 76 10
PKB beta 77 7
PAK6 77 3
p38 alpha MAPK 80 4
p38 beta MAPK 80 5
PKC alpha 83 5
EF2K 86 3
p38 gamma MAPK 86 4
EPH-B3 90 11
JNK1 99 1
IR 101 11
Screening Concentration: 0.1µM
Kinase % Activity Remainingsort descending Standard Deviation
CHK2 -1 0
ERK8 5 0
AMPK 5 0
VEGFR1 7 0
MKK1 8 1
MST2 8 0
GSK3 beta 11 1
PHK 13 0
BRSK2 13 3
MARK3 16 3
MELK 16 0
FGF-R1 17 3
DYRK2 19 3
DYRK3 19 3
PDK1 20 1
RSK1 24 4
PRK2 25 11
TBK1 27 17
PIM3 30 0
PKD1 30 2
YES1 32 4
HIPK2 33 1
IRR 35 0
RSK2 38 4
Src 41 2
DYRK1A 42 9
PIM1 43 2
Lck 44 4
IGF-1R 49 49
IKK epsilon 51 14
SmMLCK 54 7
MST4 55 32
CDK2-Cyclin A 63 0
PAK4 64 5
CAMKK beta 67 7
ERK1 71 7
MNK2 75 12
PAK5 75 10
IKK beta 75 1
S6K1 76 0
PIM2 76 6
SGK1 77 5
PKA 78 0
MNK1 80 0
ERK2 81 10
p38 alpha MAPK 81 8
PKB alpha 85 4
CHK1 85 2
PKC zeta 85 4
p38 delta MAPK 85 9
MAPKAP-K2 86 3
PAK6 86 1
PLK1 86 5
BTK 86 11
PKB beta 88 3
CK1 delta 90 0
SRPK1 90 4
NEK6 92 6
CK2 93 17
EPH-A2 93 0
p38 gamma MAPK 93 6
PRAK 95 6
SYK 95 23
CSK 98 0
MSK1 98 1
NEK2a 100 10
EF2K 102 14
ROCK 2 103 25
p38 beta MAPK 103 0
PKC alpha 106 3
EPH-B3 107 1
IR 112 14
CAMK1 112 12
JNK1 124 1
JNK2 214 172
Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
MST2 0 0
MELK 0 0
PDK1 0 2
DYRK2 0 0
PHK 0 0
IGF-1R 1 0
HIPK2 1 0
VEGFR1 1 0
ERK8 1 0
Src 1 0
DYRK3 1 0
SmMLCK 1 1
FGF-R1 1 0
CHK1 1 0
CHK2 1 4
MKK1 2 1
PIM1 2 2
YES1 3 1
PKD1 3 2
MARK3 3 1
Lck 3 0
GSK3 beta 3 2
AMPK 4 1
ERK1 4 0
RSK1 5 0
IRR 5 2
PRK2 6 0
CDK2-Cyclin A 6 0
SGK1 6 2
PIM3 7 2
ROCK 2 7 1
SYK 7 0
PAK5 8 0
PRAK 8 1
PIM2 8 0
BTK 9 6
MAPKAP-K2 10 6
IKK epsilon 11 6
TBK1 11 9
S6K1 12 1
MNK2 16 2
ERK2 16 3
JNK2 17 0
PLK1 18 6
BRSK2 18 3
CAMK1 19 0
CK1 delta 20 5
EPH-A2 20 1
PKC zeta 21 4
CK2 21 1
MST4 21 6
p38 delta MAPK 22 1
RSK2 22 3
IR 26 6
IKK beta 26 4
PKC alpha 27 7
DYRK1A 27 33
NEK2a 28 1
PAK4 29 31
MSK1 30 0
MNK1 30 14
PKA 32 5
CAMKK beta 35 3
SRPK1 36 3
PKB beta 36 4
PAK6 38 4
NEK6 38 2
CSK 42 6
p38 alpha MAPK 45 6
JNK1 48 4
p38 beta MAPK 49 9
EPH-B3 53 8
PKB alpha 62 7
p38 gamma MAPK 75 27
EF2K 116 7

Do you need any help? Please get in touch and we’ll be happy to lend a hand.