Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
BX-517 Analog (compound 7b) C19H15N5O2 345.35 PDK1 Islam I. (2007) Bioorganic and Medicinal Chemistry Letters 17 3819-3825 Download

Results as Barchart

View results as a bar chart
0.1µM
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 1 0
ERK1 60 52
ERK2 41 9
JNK1 99 1
JNK2 43 0
p38 alpha MAPK 80 4
p38 beta MAPK 80 5
p38 gamma MAPK 86 4
p38 delta MAPK 62 1
ERK8 2 0
RSK1 10 4
RSK2 32 14
PDK1 3 0
PKB alpha 69 0
PKB beta 77 7
SGK1 32 0
S6K1 32 0
PKA 66 0
ROCK 2 37 4
PRK2 5 3
PKC alpha 83 5
PKC zeta 66 1
PKD1 3 0
MSK1 73 2
MNK1 54 0
MNK2 46 5
MAPKAP-K2 49 6
PRAK 50 6
CAMKK beta 41 12
CAMK1 69 5
SmMLCK 11 1
PHK 1 0
CHK1 4 0
CHK2 -5 0
GSK3 beta 7 3
CDK2-Cyclin A 14 2
PLK1 42 4
AMPK 6 4
MARK3 5 1
BRSK2 10 3
MELK 3 0
CK1 delta 59 10
CK2 65 5
DYRK1A 11 6
DYRK2 2 0
DYRK3 4 1
NEK2a 75 2
NEK6 76 10
IKK beta 75 27
IKK epsilon 12 1
TBK1 7 6
PIM1 9 0
PIM2 34 0
PIM3 9 2
SRPK1 75 1
EF2K 86 3
HIPK2 7 0
PAK4 31 0
PAK5 43 0
PAK6 77 3
MST2 2 1
MST4 18 0
Src 7 0
Lck 10 0
CSK 69 6
YES1 8 0
BTK 29 5
SYK 40 1
EPH-A2 54 5
EPH-B3 90 11
FGF-R1 2 0
IGF-1R 33 7
IR 101 11
IRR 16 5
VEGFR1 3 1
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 8 1
ERK1 71 7
ERK2 81 10
JNK1 124 1
JNK2 214 172
p38 alpha MAPK 81 8
p38 beta MAPK 103 0
p38 gamma MAPK 93 6
p38 delta MAPK 85 9
ERK8 5 0
RSK1 24 4
RSK2 38 4
PDK1 20 1
PKB alpha 85 4
PKB beta 88 3
SGK1 77 5
S6K1 76 0
PKA 78 0
ROCK 2 103 25
PRK2 25 11
PKC alpha 106 3
PKC zeta 85 4
PKD1 30 2
MSK1 98 1
MNK1 80 0
MNK2 75 12
MAPKAP-K2 86 3
PRAK 95 6
CAMKK beta 67 7
CAMK1 112 12
SmMLCK 54 7
PHK 13 0
CHK1 85 2
CHK2 -1 0
GSK3 beta 11 1
CDK2-Cyclin A 63 0
PLK1 86 5
AMPK 5 0
MARK3 16 3
BRSK2 13 3
MELK 16 0
CK1 delta 90 0
CK2 93 17
DYRK1A 42 9
DYRK2 19 3
DYRK3 19 3
NEK2a 100 10
NEK6 92 6
IKK beta 75 1
IKK epsilon 51 14
TBK1 27 17
PIM1 43 2
PIM2 76 6
PIM3 30 0
SRPK1 90 4
EF2K 102 14
HIPK2 33 1
PAK4 64 5
PAK5 75 10
PAK6 86 1
MST2 8 0
MST4 55 32
Src 41 2
Lck 44 4
CSK 98 0
YES1 32 4
BTK 86 11
SYK 95 23
EPH-A2 93 0
EPH-B3 107 1
FGF-R1 17 3
IGF-1R 49 49
IR 112 14
IRR 35 0
VEGFR1 7 0
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 2 1
ERK1 4 0
ERK2 16 3
JNK1 48 4
JNK2 17 0
p38 alpha MAPK 45 6
p38 beta MAPK 49 9
p38 gamma MAPK 75 27
p38 delta MAPK 22 1
ERK8 1 0
RSK1 5 0
RSK2 22 3
PDK1 0 2
PKB alpha 62 7
PKB beta 36 4
SGK1 6 2
S6K1 12 1
PKA 32 5
ROCK 2 7 1
PRK2 6 0
PKC alpha 27 7
PKC zeta 21 4
PKD1 3 2
MSK1 30 0
MNK1 30 14
MNK2 16 2
MAPKAP-K2 10 6
PRAK 8 1
CAMKK beta 35 3
CAMK1 19 0
SmMLCK 1 1
PHK 0 0
CHK1 1 0
CHK2 1 4
GSK3 beta 3 2
CDK2-Cyclin A 6 0
PLK1 18 6
AMPK 4 1
MARK3 3 1
BRSK2 18 3
MELK 0 0
CK1 delta 20 5
CK2 21 1
DYRK1A 27 33
DYRK2 0 0
DYRK3 1 0
NEK2a 28 1
NEK6 38 2
IKK beta 26 4
IKK epsilon 11 6
TBK1 11 9
PIM1 2 2
PIM2 8 0
PIM3 7 2
SRPK1 36 3
EF2K 116 7
HIPK2 1 0
PAK4 29 31
PAK5 8 0
PAK6 38 4
MST2 0 0
MST4 21 6
Src 1 0
Lck 3 0
CSK 42 6
YES1 3 1
BTK 9 6
SYK 7 0
EPH-A2 20 1
EPH-B3 53 8
FGF-R1 1 0
IGF-1R 1 0
IR 26 6
IRR 5 2
VEGFR1 1 0

Do you need any help? Please get in touch and we’ll be happy to lend a hand.