Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
BX-517 C15H14N4O2 282.3 PDK1 Islam I. (2007) Bioorganic and Medicinal Chemistry Letters 17 3814-3818 CN102639566 EMD Millipore Download

Results as Barchart

View results as a bar chart
0.001µM
0.01µM
0.1µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remainingsort descending Standard Deviation
CHK2 0 5
MKK1 7 0
AMPK 7 1
ERK8 7 2
MELK 9 0
MST2 10 2
BRSK2 12 0
VEGFR1 13 2
MARK3 14 3
DYRK2 18 3
FGF-R1 18 2
PHK 18 1
RSK2 19 1
PDK1 20 5
CHK1 21 2
RSK1 24 2
PIM3 25 4
PKD1 27 7
DYRK3 33 1
PRK2 36 5
YES1 42 2
TBK1 43 3
IRR 47 10
GSK3 beta 49 14
HIPK2 51 2
MST4 56 20
SGK1 58 9
CAMKK beta 60 12
Lck 64 4
SmMLCK 65 6
PIM2 65 14
DYRK1A 67 7
PIM1 69 0
IKK epsilon 69 0
Src 71 4
PLK1 72 8
PAK4 76 8
MNK2 78 8
PAK5 78 7
ERK2 79 5
PKB alpha 80 21
MSK1 80 6
PKA 81 13
NEK6 82 7
ERK1 82 15
p38 gamma MAPK 82 1
MNK1 82 1
S6K1 83 0
PKC zeta 83 0
PKB beta 84 22
IKK beta 84 20
ROCK 2 84 4
p38 alpha MAPK 84 11
CDK2-Cyclin A 85 13
CK2 86 0
NEK2a 86 14
p38 delta MAPK 86 9
EPH-A2 87 2
PAK6 88 9
CK1 delta 89 0
SRPK1 93 9
BTK 93 5
MAPKAP-K2 94 33
PRAK 94 12
IGF-1R 94 2
SYK 97 16
EPH-B3 101 2
CSK 102 10
CAMK1 103 17
p38 beta MAPK 105 3
JNK1 106 1
EF2K 106 1
PKC alpha 107 15
IR 110 3
JNK2 118 12
Screening Concentration: 0.01µM
Kinase % Activity Remainingsort descending Standard Deviation
CHK2 7 7
BRSK2 21 3
AMPK 25 4
MKK1 33 1
MST2 36 2
MELK 47 1
ERK8 49 1
VEGFR1 50 1
PKD1 55 2
DYRK2 59 0
YES1 60 9
MARK3 61 2
FGF-R1 61 4
PRK2 61 4
PDK1 62 3
IGF-1R 63 34
RSK2 65 2
PHK 66 5
CHK1 66 22
PIM3 73 3
DYRK3 74 4
IKK beta 74 0
RSK1 75 13
IRR 75 7
PKB alpha 76 6
Src 79 4
MST4 80 5
HIPK2 82 3
PKB beta 82 11
PLK1 82 8
TBK1 83 5
PAK5 83 24
PKC zeta 84 2
NEK6 84 6
IKK epsilon 84 7
PAK4 85 11
BTK 85 4
p38 alpha MAPK 86 1
MNK2 86 6
MAPKAP-K2 86 1
SGK1 86 4
p38 gamma MAPK 87 2
MSK1 87 0
MNK1 87 2
PKA 87 8
CDK2-Cyclin A 87 3
p38 delta MAPK 89 6
SmMLCK 89 5
ERK1 89 8
PRAK 90 4
CAMKK beta 90 5
ROCK 2 90 3
CK2 91 10
DYRK1A 91 13
S6K1 91 10
NEK2a 92 2
GSK3 beta 92 7
PIM2 92 4
CK1 delta 94 0
Lck 95 15
ERK2 95 8
SRPK1 96 2
CSK 97 9
PIM1 98 2
EPH-B3 99 2
p38 beta MAPK 100 3
EF2K 101 8
EPH-A2 101 15
IR 102 7
PAK6 102 0
SYK 104 5
PKC alpha 113 1
CAMK1 116 15
JNK1 117 18
JNK2 123 9
Screening Concentration: 0.001µM
Kinase % Activity Remainingsort descending Standard Deviation
CHK2 32 7
BRSK2 59 5
AMPK 62 0
PRK2 67 3
IGF-1R 71 59
IKK beta 76 5
YES1 77 8
PKC zeta 78 8
PKB beta 79 7
PAK4 80 7
PKD1 81 2
RSK2 82 4
MST2 83 5
MSK1 83 1
DYRK3 83 3
PAK5 84 13
Src 84 0
IKK epsilon 85 6
ERK8 85 7
PKB alpha 85 1
PLK1 86 18
MELK 86 4
NEK6 86 7
MKK1 87 0
MST4 87 11
p38 alpha MAPK 87 4
ROCK 2 88 10
DYRK2 88 5
CHK1 89 8
p38 gamma MAPK 89 12
HIPK2 89 6
RSK1 89 3
SmMLCK 90 0
IRR 91 1
PKA 92 1
MNK1 92 9
CK2 92 7
NEK2a 92 14
MARK3 93 18
MNK2 93 2
CK1 delta 94 3
PDK1 94 6
S6K1 95 16
VEGFR1 95 7
BTK 95 4
PIM3 96 13
p38 delta MAPK 96 10
FGF-R1 96 8
EPH-A2 97 1
ERK1 97 3
PIM1 97 12
GSK3 beta 97 21
PIM2 97 23
PAK6 97 10
Lck 97 10
PHK 97 10
SRPK1 98 14
MAPKAP-K2 98 11
SGK1 98 16
TBK1 99 4
EF2K 99 29
SYK 100 7
PRAK 100 16
CAMKK beta 101 5
CDK2-Cyclin A 102 3
PKC alpha 102 9
p38 beta MAPK 104 15
CAMK1 104 12
ERK2 108 11
IR 109 20
DYRK1A 110 18
JNK1 114 2
EPH-B3 114 10
CSK 114 32
JNK2 159 63

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