Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
BX-517 C15H14N4O2 282.3 PDK1 Islam I. (2007) Bioorganic and Medicinal Chemistry Letters 17 3814-3818 CN102639566 EMD Millipore Download

Results as Barchart

View results as a bar chart
0.001µM
0.01µM
0.1µM

Results as Table

Screening Concentration: 0.001µM
Kinase % Activity Remaining Standard Deviation
MKK1 87 0
ERK1 97 3
ERK2 108 11
JNK1 114 2
JNK2 159 63
p38 alpha MAPK 87 4
p38 beta MAPK 104 15
p38 gamma MAPK 89 12
p38 delta MAPK 96 10
ERK8 85 7
RSK1 89 3
RSK2 82 4
PDK1 94 6
PKB alpha 85 1
PKB beta 79 7
SGK1 98 16
S6K1 95 16
PKA 92 1
ROCK 2 88 10
PRK2 67 3
PKC alpha 102 9
PKC zeta 78 8
PKD1 81 2
MSK1 83 1
MNK1 92 9
MNK2 93 2
MAPKAP-K2 98 11
PRAK 100 16
CAMKK beta 101 5
CAMK1 104 12
SmMLCK 90 0
PHK 97 10
CHK1 89 8
CHK2 32 7
GSK3 beta 97 21
CDK2-Cyclin A 102 3
PLK1 86 18
AMPK 62 0
MARK3 93 18
BRSK2 59 5
MELK 86 4
CK1 delta 94 3
CK2 92 7
DYRK1A 110 18
DYRK2 88 5
DYRK3 83 3
NEK2a 92 14
NEK6 86 7
IKK beta 76 5
IKK epsilon 85 6
TBK1 99 4
PIM1 97 12
PIM2 97 23
PIM3 96 13
SRPK1 98 14
EF2K 99 29
HIPK2 89 6
PAK4 80 7
PAK5 84 13
PAK6 97 10
MST2 83 5
MST4 87 11
Src 84 0
Lck 97 10
CSK 114 32
YES1 77 8
BTK 95 4
SYK 100 7
EPH-A2 97 1
EPH-B3 114 10
FGF-R1 96 8
IGF-1R 71 59
IR 109 20
IRR 91 1
VEGFR1 95 7
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 7 0
ERK1 82 15
ERK2 79 5
JNK1 106 1
JNK2 118 12
p38 alpha MAPK 84 11
p38 beta MAPK 105 3
p38 gamma MAPK 82 1
p38 delta MAPK 86 9
ERK8 7 2
RSK1 24 2
RSK2 19 1
PDK1 20 5
PKB alpha 80 21
PKB beta 84 22
SGK1 58 9
S6K1 83 0
PKA 81 13
ROCK 2 84 4
PRK2 36 5
PKC alpha 107 15
PKC zeta 83 0
PKD1 27 7
MSK1 80 6
MNK1 82 1
MNK2 78 8
MAPKAP-K2 94 33
PRAK 94 12
CAMKK beta 60 12
CAMK1 103 17
SmMLCK 65 6
PHK 18 1
CHK1 21 2
CHK2 0 5
GSK3 beta 49 14
CDK2-Cyclin A 85 13
PLK1 72 8
AMPK 7 1
MARK3 14 3
BRSK2 12 0
MELK 9 0
CK1 delta 89 0
CK2 86 0
DYRK1A 67 7
DYRK2 18 3
DYRK3 33 1
NEK2a 86 14
NEK6 82 7
IKK beta 84 20
IKK epsilon 69 0
TBK1 43 3
PIM1 69 0
PIM2 65 14
PIM3 25 4
SRPK1 93 9
EF2K 106 1
HIPK2 51 2
PAK4 76 8
PAK5 78 7
PAK6 88 9
MST2 10 2
MST4 56 20
Src 71 4
Lck 64 4
CSK 102 10
YES1 42 2
BTK 93 5
SYK 97 16
EPH-A2 87 2
EPH-B3 101 2
FGF-R1 18 2
IGF-1R 94 2
IR 110 3
IRR 47 10
VEGFR1 13 2
Screening Concentration: 0.01µM
Kinase % Activity Remaining Standard Deviation
MKK1 33 1
ERK1 89 8
ERK2 95 8
JNK1 117 18
JNK2 123 9
p38 alpha MAPK 86 1
p38 beta MAPK 100 3
p38 gamma MAPK 87 2
p38 delta MAPK 89 6
ERK8 49 1
RSK1 75 13
RSK2 65 2
PDK1 62 3
PKB alpha 76 6
PKB beta 82 11
SGK1 86 4
S6K1 91 10
PKA 87 8
ROCK 2 90 3
PRK2 61 4
PKC alpha 113 1
PKC zeta 84 2
PKD1 55 2
MSK1 87 0
MNK1 87 2
MNK2 86 6
MAPKAP-K2 86 1
PRAK 90 4
CAMKK beta 90 5
CAMK1 116 15
SmMLCK 89 5
PHK 66 5
CHK1 66 22
CHK2 7 7
GSK3 beta 92 7
CDK2-Cyclin A 87 3
PLK1 82 8
AMPK 25 4
MARK3 61 2
BRSK2 21 3
MELK 47 1
CK1 delta 94 0
CK2 91 10
DYRK1A 91 13
DYRK2 59 0
DYRK3 74 4
NEK2a 92 2
NEK6 84 6
IKK beta 74 0
IKK epsilon 84 7
TBK1 83 5
PIM1 98 2
PIM2 92 4
PIM3 73 3
SRPK1 96 2
EF2K 101 8
HIPK2 82 3
PAK4 85 11
PAK5 83 24
PAK6 102 0
MST2 36 2
MST4 80 5
Src 79 4
Lck 95 15
CSK 97 9
YES1 60 9
BTK 85 4
SYK 104 5
EPH-A2 101 15
EPH-B3 99 2
FGF-R1 61 4
IGF-1R 63 34
IR 102 7
IRR 75 7
VEGFR1 50 1

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