Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
BMS345541 (IKK Inhibitor III) C14H17N5 255.32 IKBKB Du Z. (2012) J Interferon Cytokine Res. 368-77 DE4329970 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remainingsort ascending Standard Deviation
TrkA 169 18
HER4 145 13
PAK4 139 28
PAK5 139 14
Src 135 27
CSK 135 1
MAPKAP-K3 129 15
CHK1 129 19
IRAK4 127 19
EPH-B2 126 9
PKC zeta 124 2
MLK3 123 16
ERK1 121 7
CHK2 121 7
MNK2 119 3
IKK epsilon 119 13
MARK2 118 6
Aurora A 117 6
NEK2a 117 3
MINK1 117 25
PKB beta 117 14
EF2K 117 12
ERK2 116 23
JNK2 116 2
PRK2 116 8
CK2 116 8
YES1 115 7
p38 gamma MAPK 114 9
p38 alpha MAPK 113 16
PAK2 113 9
PIM2 113 1
MKK1 113 10
PKA 112 6
PLK1 111 9
MAPKAP-K2 111 3
JAK2 111 12
TBK1 111 2
SRPK1 111 3
EPH-B4 111 9
JNK1 111 19
PKD1 110 7
GCK 110 3
SmMLCK 110 7
ROCK 2 110 2
Lck 109 9
RSK2 109 5
MARK1 109 2
PHK 109 3
DAPK1 109 8
IR 109 1
DYRK1A 108 2
DYRK3 107 1
Aurora B 107 35
PDK1 107 2
MARK4 107 3
HIPK3 106 4
NEK6 105 0
BTK 105 17
CAMKK beta 105 1
PIM1 105 1
S6K1 105 1
TAK1 105 10
MLK1 104 34
CK1 delta 104 19
JNK3 104 20
PAK6 103 11
EPH-A4 103 7
BRSK2 103 6
MELK 103 5
FGF-R1 103 12
CLK2 102 12
SGK1 102 17
BRSK1 102 8
RIPK2 102 4
GSK3 beta 102 19
TTK 102 8
p38 delta MAPK 101 2
MEKK1 101 2
HIPK1 101 9
p38 beta MAPK 100 4
LKB1 99 6
EPH-A2 98 11
HIPK2 98 3
CDK2-Cyclin A 97 9
MNK1 97 22
RSK1 97 3
AMPK 97 4
SYK 97 1
MARK3 97 11
EPH-B3 97 5
NUAK1 97 5
PKC alpha 96 13
IRR 94 3
VEGFR1 94 4
MST4 94 1
MSK1 93 7
ERK8 93 5
PRAK 93 8
PKB alpha 92 0
DYRK2 89 8
PIM3 87 4
MST2 86 8
CAMK1 85 26
IGF-1R 81 3
IKK beta 57 2
Screening Concentration: 10µM
Kinase % Activity Remainingsort ascending Standard Deviation
EPH-B4 132 13
DAPK1 118 45
PLK1 116 2
RIPK2 113 19
PRAK 111 7
PAK2 110 1
MARK1 110 3
MARK3 109 11
IR 109 1
Aurora A 108 3
PAK4 106 7
HER4 105 9
SRPK1 104 4
MARK2 103 5
PKB beta 103 1
MARK4 103 10
PKC zeta 102 8
p38 gamma MAPK 102 3
TAK1 101 13
JNK1 101 0
p38 alpha MAPK 101 3
p38 beta MAPK 101 2
RSK1 101 2
IKK epsilon 101 8
PRK2 100 3
MNK2 100 6
MAPKAP-K2 100 3
CAMKK beta 99 1
EF2K 99 3
TrkA 99 8
PDK1 98 6
BTK 98 15
ERK2 97 2
IRAK4 97 7
PAK5 97 7
MKK1 96 3
HIPK1 96 14
HIPK3 96 9
PAK6 96 7
SYK 96 1
PIM1 95 2
PKA 94 4
MELK 94 13
MAPKAP-K3 94 3
MINK1 93 7
IGF-1R 93 2
CSK 93 6
MEKK1 92 3
EPH-B2 92 12
MST2 92 7
SGK1 91 4
MLK3 91 2
p38 delta MAPK 91 3
AMPK 91 1
PKC alpha 90 4
Src 90 7
NEK2a 90 7
TBK1 89 9
BRSK1 89 21
MLK1 89 6
MST4 89 5
PKB alpha 88 5
PHK 88 4
CHK2 88 2
MNK1 88 3
GCK 87 5
ERK1 87 6
JAK2 87 2
CHK1 86 3
NEK6 86 7
TTK 85 4
BRSK2 84 4
YES1 84 12
EPH-A4 83 1
PIM2 83 5
S6K1 83 3
JNK2 83 2
GSK3 beta 82 7
MSK1 82 2
JNK3 81 3
RSK2 81 8
ROCK 2 80 5
CK2 79 1
Lck 79 4
SmMLCK 77 2
DYRK1A 77 3
IRR 76 3
CLK2 74 3
CAMK1 73 8
FGF-R1 73 18
DYRK3 71 2
LKB1 71 8
PIM3 70 3
VEGFR1 69 2
HIPK2 67 1
EPH-A2 65 0
Aurora B 64 7
EPH-B3 61 1
CDK2-Cyclin A 60 4
CK1 delta 55 5
PKD1 54 5
DYRK2 46 0
NUAK1 45 5
ERK8 18 2
IKK beta 16 6

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