Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
BIRB-0796 (Doramapimod) C31H37N5O3 527.66 p38 MAPK Regan J. (2002) J. Med. Chem 45 2994-3008 WO2004014387 Axon Download

Results as Barchart

View results as a bar chart
1µM
0.1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
p38 alpha MAPK 3 0
JNK2 4 0
p38 beta MAPK 13 4
VEGFR1 14 0
RSK1 34 2
p38 gamma MAPK 35 3
FGF-R1 40 4
p38 delta MAPK 40 5
BRSK2 47 6
RSK2 48 6
Lck 51 7
GSK3 beta 53 7
MKK1 55 4
EPH-B3 57 3
PIM3 60 3
MELK 60 2
SYK 62 0
MARK3 62 4
PKC alpha 62 2
PHK 67 7
PKA 68 4
JNK3 68 0
CSK 69 1
PAK4 70 5
IGF-1R 72 0
SGK1 72 1
YES1 73 4
PRK2 73 7
CHK1 73 2
IKK beta 74 4
IRR 75 11
EPH-A2 75 5
AMPK 75 2
Aurora C 78 6
MNK1 79 1
ROCK 2 79 2
PIM1 80 3
Aurora B 82 1
DYRK2 82 4
PAK6 82 0
CDK2-Cyclin A 83 6
MSK1 84 5
CAMK1 84 6
IKK epsilon 85 5
NEK6 86 2
PLK1 86 9
PDK1 86 5
NEK2a 86 5
CAMKK beta 87 2
MST2 88 6
MAPKAP-K3 89 3
PKB alpha 89 7
PKB beta 89 2
MNK2 90 0
JNK1 90 1
EF2K 92 3
PAK5 92 2
TBK1 92 1
PKD1 93 7
PRAK 93 4
Src 93 4
SRPK1 94 1
SmMLCK 94 1
ERK8 95 6
CAMKK alpha 95 4
ERK2 95 10
CK2 96 5
CK1 delta 97 8
ERK1 97 0
DYRK1A 97 5
HIPK2 99 2
S6K1 99 6
MST4 100 14
BTK 101 0
DYRK3 101 4
NEK7 103 0
HIPK3 103 1
MAPKAP-K2 105 3
IR 113 0
PKC zeta 116 6
CHK2 117 0
PIM2 124 5
Screening Concentration: 0.1µM
Kinase % Activity Remainingsort descending Standard Deviation
JNK2 27 1
p38 alpha MAPK 28 4
MKK1 61 8
VEGFR1 66 0
p38 beta MAPK 69 1
p38 gamma MAPK 75 4
SYK 76 0
IGF-1R 77 12
FGF-R1 81 12
PAK4 83 2
PKB alpha 84 20
RSK1 86 12
MAPKAP-K2 87 5
MST4 88 4
Src 88 1
CAMK1 88 4
DYRK2 88 3
Lck 88 4
SGK1 88 7
IRR 88 14
PKC zeta 89 7
AMPK 89 3
p38 delta MAPK 89 1
ROCK 2 91 9
PIM2 91 3
MSK1 91 3
MARK3 91 14
IR 91 1
MNK2 91 1
DYRK3 91 6
PKA 92 6
PAK6 93 4
CSK 93 2
YES1 94 7
BRSK2 94 0
DYRK1A 94 0
CHK2 94 2
IKK beta 94 9
PIM1 95 1
PIM3 95 11
MST2 95 16
HIPK2 95 0
TBK1 95 4
CAMKK beta 95 0
SmMLCK 95 2
S6K1 95 27
PRAK 96 5
IKK epsilon 96 6
CHK1 96 7
ERK2 97 8
CK1 delta 97 10
PRK2 98 3
Aurora B 98 0
NEK2a 98 3
PDK1 99 10
ERK1 99 5
PLK1 100 17
SRPK1 100 0
PKD1 100 11
MNK1 100 1
EPH-B3 100 4
RSK2 100 8
PKB beta 100 11
NEK6 100 3
JNK1 102 0
CDK2-Cyclin A 102 11
EF2K 102 1
ERK8 103 6
BTK 106 1
GSK3 beta 107 0
MELK 108 20
PAK5 108 10
EPH-A2 112 0
PKC alpha 113 6
PHK 117 11
CK2 120 13

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