Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
BIRB-0796 (Doramapimod) C31H37N5O3 527.66 p38 MAPK Regan J. (2002) J. Med. Chem 45 2994-3008 WO2004014387 Axon Download

Results as Barchart

View results as a bar chart
1µM
0.1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 55 4
ERK1 97 0
ERK2 95 10
JNK1 90 1
JNK2 4 0
JNK3 68 0
p38 alpha MAPK 3 0
p38 beta MAPK 13 4
p38 gamma MAPK 35 3
p38 delta MAPK 40 5
ERK8 95 6
RSK1 34 2
RSK2 48 6
PDK1 86 5
PKB alpha 89 7
PKB beta 89 2
SGK1 72 1
S6K1 99 6
PKA 68 4
ROCK 2 79 2
PRK2 73 7
PKC alpha 62 2
PKC zeta 116 6
PKD1 93 7
MSK1 84 5
MNK1 79 1
MNK2 90 0
MAPKAP-K2 105 3
MAPKAP-K3 89 3
PRAK 93 4
CAMKK alpha 95 4
CAMKK beta 87 2
CAMK1 84 6
SmMLCK 94 1
PHK 67 7
CHK1 73 2
CHK2 117 0
GSK3 beta 53 7
CDK2-Cyclin A 83 6
PLK1 86 9
Aurora B 82 1
Aurora C 78 6
AMPK 75 2
MARK3 62 4
BRSK2 47 6
MELK 60 2
CK1 delta 97 8
CK2 96 5
DYRK1A 97 5
DYRK2 82 4
DYRK3 101 4
NEK2a 86 5
NEK6 86 2
NEK7 103 0
IKK beta 74 4
IKK epsilon 85 5
TBK1 92 1
PIM1 80 3
PIM2 124 5
PIM3 60 3
SRPK1 94 1
EF2K 92 3
HIPK2 99 2
HIPK3 103 1
PAK4 70 5
PAK5 92 2
PAK6 82 0
MST2 88 6
MST4 100 14
Src 93 4
Lck 51 7
CSK 69 1
YES1 73 4
BTK 101 0
SYK 62 0
EPH-A2 75 5
EPH-B3 57 3
FGF-R1 40 4
IGF-1R 72 0
IR 113 0
IRR 75 11
VEGFR1 14 0
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 61 8
ERK1 99 5
ERK2 97 8
JNK1 102 0
JNK2 27 1
p38 alpha MAPK 28 4
p38 beta MAPK 69 1
p38 gamma MAPK 75 4
p38 delta MAPK 89 1
ERK8 103 6
RSK1 86 12
RSK2 100 8
PDK1 99 10
PKB alpha 84 20
PKB beta 100 11
SGK1 88 7
S6K1 95 27
PKA 92 6
ROCK 2 91 9
PRK2 98 3
PKC alpha 113 6
PKC zeta 89 7
PKD1 100 11
MSK1 91 3
MNK1 100 1
MNK2 91 1
MAPKAP-K2 87 5
PRAK 96 5
CAMKK beta 95 0
CAMK1 88 4
SmMLCK 95 2
PHK 117 11
CHK1 96 7
CHK2 94 2
GSK3 beta 107 0
CDK2-Cyclin A 102 11
PLK1 100 17
Aurora B 98 0
AMPK 89 3
MARK3 91 14
BRSK2 94 0
MELK 108 20
CK1 delta 97 10
CK2 120 13
DYRK1A 94 0
DYRK2 88 3
DYRK3 91 6
NEK2a 98 3
NEK6 100 3
IKK beta 94 9
IKK epsilon 96 6
TBK1 95 4
PIM1 95 1
PIM2 91 3
PIM3 95 11
SRPK1 100 0
EF2K 102 1
HIPK2 95 0
PAK4 83 2
PAK5 108 10
PAK6 93 4
MST2 95 16
MST4 88 4
Src 88 1
Lck 88 4
CSK 93 2
YES1 94 7
BTK 106 1
SYK 76 0
EPH-A2 112 0
EPH-B3 100 4
FGF-R1 81 12
IGF-1R 77 12
IR 91 1
IRR 88 14
VEGFR1 66 0

Do you need any help? Please get in touch and we’ll be happy to lend a hand.