Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
BIO (6-Bromoindirubin-3'-oxime) C16H10BrN3O2 356.2 GSK3 Tseng A.S. (2006) Chem. Biol. 13 957 Polychronopoulos P. (2004) J. Med. Chem. 47 935 WO2007016485 Sigma Download

Results as Barchart

View results as a bar chart
0.01µM
1µM
10µM
0.1µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remainingsort ascending Standard Deviation
IR 129 12
MKK6 118 12
RSK2 114 6
MST4 112 1
ERK2 112 12
PKD1 112 15
CK1 delta 111 4
EPH-B4 111 3
RIPK2 111 6
JNK1 110 2
PKA 109 4
TAO1 109 7
HIPK3 108 14
SRPK1 107 10
p38 delta MAPK 106 4
IKK beta 106 5
JNK2 105 9
ROCK 2 105 8
p38 alpha MAPK 105 2
MKK2 104 9
PKB alpha 104 2
ERK1 104 3
PRAK 103 2
PRK2 103 2
EPH-B1 102 1
NEK2a 102 3
NEK6 102 8
MARK1 100 8
MKK1 100 13
HER4 100 1
PAK6 100 6
PIM1 99 7
HIPK1 98 3
PKC alpha 97 5
PKC zeta 96 1
DYRK3 96 2
MNK1 96 1
PLK1 95 6
MARK2 94 5
ASK1 94 2
p38 gamma MAPK 94 5
MSK1 94 8
S6K1 93 6
EPH-B3 93 5
CK2 92 1
PAK5 92 2
MAPKAP-K3 91 11
DYRK1A 91 5
MAPKAP-K2 91 2
PIM2 88 8
EPH-A4 88 5
JNK3 88 6
IRR 88 2
CSK 87 8
PKB beta 86 1
TTK 86 6
EF2K 85 2
EPH-B2 85 6
DYRK2 85 8
PDK1 84 6
CAMKK beta 83 2
RSK1 82 2
MARK4 81 4
CLK2 81 1
IKK epsilon 80 12
MEKK1 78 7
CHK1 78 5
PAK4 78 7
SGK1 77 10
p38 beta MAPK 77 6
PAK2 77 1
ERK8 76 2
MNK2 76 2
SYK 75 9
EPH-A2 75 14
LKB1 75 1
IRAK4 74 8
PIM3 73 3
MARK3 72 5
SmMLCK 71 6
MELK 71 1
TAK1 71 2
MINK1 67 1
CHK2 67 3
IGF-1R 63 5
DAPK1 60 0
HIPK2 58 2
JAK2 56 2
TBK1 54 0
GCK 52 0
PHK 51 3
NUAK1 51 8
Aurora B 51 11
Aurora A 50 3
MLK1 48 2
BRSK2 48 1
FGF-R1 43 5
YES1 41 4
AMPK 40 5
Lck 38 2
BTK 29 4
CDK2-Cyclin A 29 1
VEGFR1 27 1
CAMK1 26 7
MST2 19 1
Src 16 5
BRSK1 14 3
MLK3 14 3
TrkA 13 0
GSK3 beta 7 0
Screening Concentration: 0.01µM
Kinase % Activity Remainingsort ascending Standard Deviation
MNK1 118 4
PKC alpha 113 1
BRSK2 112 5
PIM2 111 5
CSK 109 9
EF2K 108 9
p38 delta MAPK 108 10
DYRK3 108 4
IR 107 0
RSK1 107 3
PAK5 107 0
PKC zeta 107 12
IKK beta 106 11
IGF-1R 106 8
MAPKAP-K2 103 6
PRK2 103 15
p38 alpha MAPK 103 22
PAK6 102 16
DYRK1A 102 10
PKA 102 1
HIPK2 101 2
IKK epsilon 101 0
PHK 101 18
PDK1 100 6
PKB beta 100 3
ROCK 2 100 5
PIM1 100 10
SYK 99 2
PKD1 98 6
MST4 98 4
JNK1 98 6
MSK1 97 6
MARK3 97 4
PRAK 97 3
CAMK1 97 17
CK2 96 3
NEK2a 96 6
MKK1 96 1
PIM3 96 8
VEGFR1 95 6
p38 gamma MAPK 95 1
ERK8 95 10
PAK4 95 18
FGF-R1 95 5
TBK1 94 13
EPH-A2 94 3
JNK2 94 5
Aurora B 94 11
BTK 93 12
RSK2 93 4
CAMKK beta 93 0
DYRK2 93 16
IRR 93 8
ERK2 93 12
AMPK 91 21
PLK1 91 6
EPH-B3 89 10
PKB alpha 89 10
Lck 89 10
SGK1 88 8
NEK6 88 12
ERK1 88 13
CDK2-Cyclin A 88 7
p38 beta MAPK 87 7
MST2 87 8
CK1 delta 87 10
S6K1 87 10
SRPK1 87 8
MNK2 86 5
MELK 86 12
GSK3 beta 85 9
SmMLCK 84 19
CHK1 82 18
CHK2 77 19
YES1 76 6
Src 73 13
Screening Concentration: 1µM
Kinase % Activity Remainingsort ascending Standard Deviation
NEK2a 91 16
ERK2 88 2
IKK beta 86 6
PKA 81 4
EF2K 81 2
CK2 76 0
NEK6 73 5
PKB alpha 72 3
p38 alpha MAPK 70 19
p38 delta MAPK 70 0
PKC zeta 69 4
MAPKAP-K2 68 7
SRPK1 68 5
ERK1 67 4
PKD1 66 3
DYRK3 58 0
JNK1 57 4
CK1 delta 57 3
MNK1 55 3
JNK2 53 1
PKB beta 51 6
PLK1 51 8
MNK2 50 0
p38 gamma MAPK 49 2
PRAK 45 5
PRK2 45 7
DYRK2 44 2
p38 beta MAPK 41 0
IR 38 3
PKC alpha 37 0
RSK2 35 3
MKK1 35 4
PIM1 35 2
EPH-B3 35 13
MSK1 27 2
PIM2 26 9
ROCK 2 24 1
PAK6 22 0
DYRK1A 22 0
S6K1 21 1
CSK 20 0
IRR 18 3
SYK 17 20
MARK3 17 4
SmMLCK 14 3
BRSK2 13 4
PAK5 13 0
CHK1 12 3
PIM3 12 3
EPH-A2 11 0
MST4 11 0
IGF-1R 11 2
CAMK1 10 0
IKK epsilon 9 0
CAMKK beta 9 0
SGK1 9 0
PAK4 9 4
GSK3 beta 8 8
RSK1 7 1
TBK1 7 1
AMPK 6 0
Src 5 1
VEGFR1 5 2
CHK2 4 2
CDK2-Cyclin A 4 0
YES1 4 0
MELK 4 2
Lck 3 1
FGF-R1 3 0
PHK 3 0
HIPK2 3 0
MST2 2 0
BTK 2 0
ERK8 2 0
PDK1 1 0
Screening Concentration: 10µM
Kinase % Activity Remainingsort ascending Standard Deviation
ERK2 83 4
EF2K 82 1
NEK2a 81 5
IKK beta 68 6
PKB alpha 67 4
CK2 59 4
MNK2 58 6
SRPK1 57 0
MNK1 56 1
p38 alpha MAPK 54 10
p38 delta MAPK 53 11
PKD1 52 8
JNK1 48 3
DYRK3 48 1
PKC zeta 47 5
PRK2 46 5
JNK2 46 2
p38 gamma MAPK 43 1
ERK1 41 2
PLK1 36 0
RSK2 36 0
MKK1 34 5
CK1 delta 34 2
MAPKAP-K2 33 27
p38 beta MAPK 31 2
DYRK2 31 4
PKA 28 2
PKC alpha 25 0
EPH-B3 25 8
PKB beta 24 12
PRAK 23 14
PIM1 22 1
PAK6 22 0
IR 20 3
CSK 19 6
IRR 17 3
BRSK2 16 0
ROCK 2 14 0
PIM2 14 4
DYRK1A 14 1
SmMLCK 14 2
NEK6 13 2
EPH-A2 11 1
MST4 11 0
IKK epsilon 11 8
MARK3 10 1
CHK1 9 1
PAK5 9 1
RSK1 9 5
GSK3 beta 8 6
MST2 8 5
MSK1 7 1
PAK4 7 2
CAMK1 7 0
IGF-1R 6 2
AMPK 6 0
HIPK2 6 3
TBK1 6 0
CAMKK beta 6 1
CDK2-Cyclin A 5 0
PIM3 5 2
Src 5 0
Lck 5 2
CHK2 4 0
YES1 4 0
MELK 4 1
PDK1 4 0
S6K1 3 0
SYK 2 0
VEGFR1 2 1
BTK 2 0
ERK8 2 0
FGF-R1 2 0
PHK 1 0
SGK1 0 0

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