Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
BIO (6-Bromoindirubin-3'-oxime) C16H10BrN3O2 356.2 GSK3 Tseng A.S. (2006) Chem. Biol. 13 957 Polychronopoulos P. (2004) J. Med. Chem. 47 935 WO2007016485 Sigma Download

Results as Barchart

View results as a bar chart
0.01µM
1µM
10µM
0.1µM

Results as Table

Screening Concentration: 0.01µM
Kinase % Activity Remaining Standard Deviation
MKK1 96 1
ERK1 88 13
ERK2 93 12
JNK1 98 6
JNK2 94 5
p38 alpha MAPK 103 22
p38 beta MAPK 87 7
p38 gamma MAPK 95 1
p38 delta MAPK 108 10
ERK8 95 10
RSK1 107 3
RSK2 93 4
PDK1 100 6
PKB alpha 89 10
PKB beta 100 3
SGK1 88 8
S6K1 87 10
PKA 102 1
ROCK 2 100 5
PRK2 103 15
PKC alpha 113 1
PKC zeta 107 12
PKD1 98 6
MSK1 97 6
MNK1 118 4
MNK2 86 5
MAPKAP-K2 103 6
PRAK 97 3
CAMKK beta 93 0
CAMK1 97 17
SmMLCK 84 19
PHK 101 18
CHK1 82 18
CHK2 77 19
GSK3 beta 85 9
CDK2-Cyclin A 88 7
PLK1 91 6
Aurora B 94 11
AMPK 91 21
MARK3 97 4
BRSK2 112 5
MELK 86 12
CK1 delta 87 10
CK2 96 3
DYRK1A 102 10
DYRK2 93 16
DYRK3 108 4
NEK2a 96 6
NEK6 88 12
IKK beta 106 11
IKK epsilon 101 0
TBK1 94 13
PIM1 100 10
PIM2 111 5
PIM3 96 8
SRPK1 87 8
EF2K 108 9
HIPK2 101 2
PAK4 95 18
PAK5 107 0
PAK6 102 16
MST2 87 8
MST4 98 4
Src 73 13
Lck 89 10
CSK 109 9
YES1 76 6
BTK 93 12
SYK 99 2
EPH-A2 94 3
EPH-B3 89 10
FGF-R1 95 5
IGF-1R 106 8
IR 107 0
IRR 93 8
VEGFR1 95 6
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 100 13
MKK2 104 9
MKK6 118 12
ERK1 104 3
ERK2 112 12
JNK1 110 2
JNK2 105 9
JNK3 88 6
p38 alpha MAPK 105 2
p38 beta MAPK 77 6
p38 gamma MAPK 94 5
p38 delta MAPK 106 4
ERK8 76 2
RSK1 82 2
RSK2 114 6
PDK1 84 6
PKB alpha 104 2
PKB beta 86 1
SGK1 77 10
S6K1 93 6
PKA 109 4
ROCK 2 105 8
PRK2 103 2
PKC alpha 97 5
PKC zeta 96 1
PKD1 112 15
MSK1 94 8
MNK1 96 1
MNK2 76 2
MAPKAP-K2 91 2
MAPKAP-K3 91 11
PRAK 103 2
CAMKK beta 83 2
CAMK1 26 7
SmMLCK 71 6
PHK 51 3
DAPK1 60 0
CHK1 78 5
CHK2 67 3
GSK3 beta 7 0
CDK2-Cyclin A 29 1
PLK1 95 6
Aurora A 50 3
Aurora B 51 11
LKB1 75 1
AMPK 40 5
MARK1 100 8
MARK2 94 5
MARK3 72 5
MARK4 81 4
BRSK1 14 3
BRSK2 48 1
MELK 71 1
NUAK1 51 8
CK1 delta 111 4
CK2 92 1
DYRK1A 91 5
DYRK2 85 8
DYRK3 96 2
NEK2a 102 3
NEK6 102 8
IKK beta 106 5
IKK epsilon 80 12
TBK1 54 0
PIM1 99 7
PIM2 88 8
PIM3 73 3
SRPK1 107 10
EF2K 85 2
HIPK1 98 3
HIPK2 58 2
HIPK3 108 14
CLK2 81 1
PAK2 77 1
PAK4 78 7
PAK5 92 2
PAK6 100 6
MST2 19 1
MST4 112 1
GCK 52 0
MINK1 67 1
MEKK1 78 7
MLK1 48 2
MLK3 14 3
TAO1 109 7
ASK1 94 2
TAK1 71 2
IRAK4 74 8
RIPK2 111 6
TTK 86 6
Src 16 5
Lck 38 2
CSK 87 8
YES1 41 4
BTK 29 4
JAK2 56 2
SYK 75 9
EPH-A2 75 14
EPH-A4 88 5
EPH-B1 102 1
EPH-B2 85 6
EPH-B3 93 5
EPH-B4 111 3
FGF-R1 43 5
HER4 100 1
IGF-1R 63 5
IR 129 12
IRR 88 2
TrkA 13 0
VEGFR1 27 1
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 34 5
ERK1 41 2
ERK2 83 4
JNK1 48 3
JNK2 46 2
p38 alpha MAPK 54 10
p38 beta MAPK 31 2
p38 gamma MAPK 43 1
p38 delta MAPK 53 11
ERK8 2 0
RSK1 9 5
RSK2 36 0
PDK1 4 0
PKB alpha 67 4
PKB beta 24 12
SGK1 0 0
S6K1 3 0
PKA 28 2
ROCK 2 14 0
PRK2 46 5
PKC alpha 25 0
PKC zeta 47 5
PKD1 52 8
MSK1 7 1
MNK1 56 1
MNK2 58 6
MAPKAP-K2 33 27
PRAK 23 14
CAMKK beta 6 1
CAMK1 7 0
SmMLCK 14 2
PHK 1 0
CHK1 9 1
CHK2 4 0
GSK3 beta 8 6
CDK2-Cyclin A 5 0
PLK1 36 0
AMPK 6 0
MARK3 10 1
BRSK2 16 0
MELK 4 1
CK1 delta 34 2
CK2 59 4
DYRK1A 14 1
DYRK2 31 4
DYRK3 48 1
NEK2a 81 5
NEK6 13 2
IKK beta 68 6
IKK epsilon 11 8
TBK1 6 0
PIM1 22 1
PIM2 14 4
PIM3 5 2
SRPK1 57 0
EF2K 82 1
HIPK2 6 3
PAK4 7 2
PAK5 9 1
PAK6 22 0
MST2 8 5
MST4 11 0
Src 5 0
Lck 5 2
CSK 19 6
YES1 4 0
BTK 2 0
SYK 2 0
EPH-A2 11 1
EPH-B3 25 8
FGF-R1 2 0
IGF-1R 6 2
IR 20 3
IRR 17 3
VEGFR1 2 1
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 35 4
ERK1 67 4
ERK2 88 2
JNK1 57 4
JNK2 53 1
p38 alpha MAPK 70 19
p38 beta MAPK 41 0
p38 gamma MAPK 49 2
p38 delta MAPK 70 0
ERK8 2 0
RSK1 7 1
RSK2 35 3
PDK1 1 0
PKB alpha 72 3
PKB beta 51 6
SGK1 9 0
S6K1 21 1
PKA 81 4
ROCK 2 24 1
PRK2 45 7
PKC alpha 37 0
PKC zeta 69 4
PKD1 66 3
MSK1 27 2
MNK1 55 3
MNK2 50 0
MAPKAP-K2 68 7
PRAK 45 5
CAMKK beta 9 0
CAMK1 10 0
SmMLCK 14 3
PHK 3 0
CHK1 12 3
CHK2 4 2
GSK3 beta 8 8
CDK2-Cyclin A 4 0
PLK1 51 8
AMPK 6 0
MARK3 17 4
BRSK2 13 4
MELK 4 2
CK1 delta 57 3
CK2 76 0
DYRK1A 22 0
DYRK2 44 2
DYRK3 58 0
NEK2a 91 16
NEK6 73 5
IKK beta 86 6
IKK epsilon 9 0
TBK1 7 1
PIM1 35 2
PIM2 26 9
PIM3 12 3
SRPK1 68 5
EF2K 81 2
HIPK2 3 0
PAK4 9 4
PAK5 13 0
PAK6 22 0
MST2 2 0
MST4 11 0
Src 5 1
Lck 3 1
CSK 20 0
YES1 4 0
BTK 2 0
SYK 17 20
EPH-A2 11 0
EPH-B3 35 13
FGF-R1 3 0
IGF-1R 11 2
IR 38 3
IRR 18 3
VEGFR1 5 2

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