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Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
BI-D-1870 C19H23N5O2F2 391.42 RSK Sapkota G.P. (2007) Biochem. J. 401 29–38 WO2003020722 Axon Download

Results as Barchart

View results as a bar chart
0.01µM
0.1µM
10µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
RSK1 0 0
RSK2 4 1
PLK1 6 2
Aurora B 7 1
MST2 7 0
MINK1 7 3
MLK3 8 4
MELK 9 0
CDK2-Cyclin A 15 2
MLK1 16 4
TAO1 18 2
VEGFR1 19 0
PIM3 19 0
Aurora A 24 0
MST4 25 2
CLK2 26 7
IRAK4 31 5
MARK3 31 5
GSK3 beta 35 3
GCK 37 3
ERK8 39 8
CAMKK beta 40 7
S6K1 41 3
IRR 43 7
PIM1 43 1
NUAK1 44 4
TAK1 49 8
MARK2 51 4
AMPK 55 2
IGF-1R 57 3
PAK4 58 0
NEK2a 59 4
DYRK1A 60 4
TrkA 60 1
HIPK2 61 1
PKD1 61 0
STK33 62 0
CK1 delta 63 1
TTK 63 2
Lck 63 7
MKK2 64 4
JAK2 66 3
PAK6 70 4
Src 72 11
MSK1 73 0
PAK5 73 1
SmMLCK 73 6
PRK2 74 2
MKK1 74 3
ERK2 74 5
ROCK 2 76 0
BRSK2 76 5
CSK 76 0
PKC gamma 77 7
MARK4 77 7
CAMK1 78 11
DYRK3 80 8
YES1 82 15
JNK2 83 0
DAPK1 83 2
SGK1 83 0
PKA 83 7
CHK2 84 5
PDK1 84 7
DYRK2 85 1
MARK1 85 2
EPH-B1 86 1
BRSK1 86 0
SYK 87 8
PAK2 88 0
IR 88 0
PRAK 88 6
HER4 89 4
MAPKAP-K3 89 1
SRPK1 90 4
EF2K 90 6
HIPK1 90 5
MNK1 90 4
ABL 90 3
TIE2 91 4
p38 alpha MAPK 91 0
MAPKAP-K2 91 5
IKK epsilon 91 0
CK2 92 1
RIPK2 92 0
LKB1 92 3
PKC zeta 93 0
EPH-B2 93 4
p38 delta MAPK 93 2
EPH-B4 94 6
ERK1 94 5
BRK 95 10
MNK2 95 3
TBK1 95 10
BTK 95 7
PKC alpha 96 14
EPH-A2 98 12
p38 gamma MAPK 98 11
NEK6 98 8
JNK3 99 3
PIM2 99 12
IKK beta 101 4
ASK1 102 3
PKB alpha 102 7
PKB beta 103 10
JNK1 104 0
EPH-A4 105 5
MPSK1 105 2
p38 beta MAPK 107 4
PHK 108 3
CHK1 108 11
FGF-R1 108 13
MKK6 108 5
MEKK1 108 13
EPH-B3 109 4
ZAP70 112 8
HIPK3 113 2
Screening Concentration: 0.1µM
Kinase % Activity Remainingsort descending Standard Deviation
RSK1 1 0
RSK2 2 5
PLK1 5 1
Aurora B 22 4
MELK 40 5
MST2 41 3
VEGFR1 59 2
PKD1 62 11
PIM3 65 3
CAMKK beta 72 12
CHK1 73 0
IRR 75 5
PIM1 75 1
Aurora C 76 4
GSK3 beta 77 5
MST4 77 8
MARK3 78 5
BRSK2 78 9
IGF-1R 79 3
FGF-R1 79 11
PKC zeta 80 1
ERK8 81 6
CK1 delta 81 5
PAK4 81 11
ROCK 2 83 13
ERK2 84 1
CDK2-Cyclin A 84 0
Lck 85 0
YES1 86 0
MNK1 87 9
EF2K 87 0
p38 alpha MAPK 87 12
PRAK 88 14
IKK epsilon 88 5
PKA 88 8
JNK1 88 6
MAPKAP-K2 89 14
PAK5 89 5
DYRK2 90 0
DYRK3 90 3
PKC alpha 90 9
EPH-A2 91 3
CAMKK alpha 92 8
SYK 94 18
SRPK1 94 7
PDK1 94 7
DYRK1A 95 9
MNK2 96 11
BTK 96 9
Src 96 3
CHK2 96 2
JNK3 96 10
PKB alpha 97 1
CK2 97 4
TBK1 97 1
NEK2a 97 10
PRK2 97 5
MKK1 98 4
CSK 98 8
p38 beta MAPK 100 4
PIM2 100 8
PKB beta 101 14
PAK6 101 9
HIPK2 102 6
CAMK1 103 8
HIPK3 104 5
p38 delta MAPK 105 8
IKK beta 105 10
IR 106 4
AMPK 107 6
SmMLCK 107 4
MAPKAP-K3 108 12
NEK7 108 0
EPH-B3 109 6
SGK1 111 7
p38 gamma MAPK 111 3
ERK1 114 2
PHK 114 13
NEK6 114 8
JNK2 115 12
S6K1 119 8
MSK1 124 5
Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
RSK2 1 0
PLK1 2 0
RSK1 2 0
MST4 3 0
PIM3 3 0
VEGFR1 3 0
MELK 3 0
Aurora A 4 0
Aurora B 4 0
MLK3 4 0
PIM1 6 0
GCK 8 2
MINK1 8 5
TrkA 8 2
TAO1 8 2
CAMKK beta 9 0
NUAK1 9 0
TAK1 9 2
CLK2 11 11
PAK4 12 0
MST2 12 1
JAK2 12 0
MLK1 12 6
FGF-R1 13 1
IR 13 2
IGF-1R 14 3
TIE2 15 3
HIPK2 15 1
STK33 20 1
IRR 20 1
BRSK2 21 1
GSK3 beta 21 3
YES1 23 6
MKK2 25 9
MARK4 27 0
TBK1 28 5
DYRK3 29 1
PAK5 29 0
CDK2-Cyclin A 30 6
TTK 30 8
IKK epsilon 31 3
CK1 delta 32 0
MARK1 33 5
Lck 34 1
PAK6 35 0
MARK3 36 2
SYK 36 5
PKC alpha 36 6
MARK2 38 0
ABL 40 2
ERK1 42 1
EPH-B3 43 1
BRSK1 43 0
DYRK2 44 4
PKC gamma 44 4
BTK 45 6
DYRK1A 46 6
SmMLCK 46 6
EPH-B2 48 4
MKK1 48 1
LKB1 49 2
EPH-B1 51 2
EPH-A2 52 0
PKD1 53 5
ERK8 54 8
S6K1 54 1
Src 59 3
HER4 59 0
CAMK1 60 9
PIM2 61 4
IRAK4 63 3
HIPK1 64 1
PKA 65 5
CHK2 65 2
EPH-A4 65 3
AMPK 67 1
SGK1 67 11
PRK2 67 6
MPSK1 69 2
ROCK 2 69 3
MSK1 70 7
JNK2 71 4
JNK3 71 1
HIPK3 72 4
RIPK2 73 1
PRAK 73 4
ERK2 73 0
PAK2 74 8
IKK beta 74 3
DAPK1 74 13
CHK1 74 6
MNK1 76 0
p38 alpha MAPK 76 11
PDK1 78 6
NEK2a 80 0
CSK 80 12
MKK6 80 1
SRPK1 80 9
JNK1 83 8
ZAP70 85 4
MNK2 86 4
MEKK1 86 6
PKC zeta 86 6
BRK 87 5
p38 delta MAPK 88 9
p38 gamma MAPK 89 4
MAPKAP-K2 89 8
p38 beta MAPK 90 9
NEK6 92 0
MAPKAP-K3 92 3
ASK1 93 3
PKB alpha 94 8
PKB beta 95 7
EF2K 96 0
PHK 99 4
CK2 99 3
EPH-B4 106 8
Screening Concentration: 0.01µM
Kinase % Activity Remainingsort descending Standard Deviation
RSK1 14 2
RSK2 32 2
PLK1 33 1
Aurora B 53 5
MAPKAP-K3 57 4
MST2 65 8
IGF-1R 71 6
PHK 77 2
IRR 79 17
PIM3 79 10
PRK2 80 5
S6K1 83 3
PRAK 84 8
GSK3 beta 84 0
PKC zeta 84 9
PAK4 85 3
MELK 85 1
VEGFR1 88 2
PAK6 88 0
NEK6 88 4
CDK2-Cyclin A 88 5
p38 beta MAPK 89 0
PKD1 89 5
p38 delta MAPK 89 0
Lck 89 2
p38 alpha MAPK 89 3
DYRK1A 90 3
BRSK2 91 4
PAK5 91 5
CSK 91 1
PKA 91 4
BTK 92 7
MAPKAP-K2 92 6
CK1 delta 93 0
CAMK1 93 5
NEK2a 93 4
JNK2 93 2
ERK8 94 1
MSK1 95 5
ERK2 95 2
IKK beta 95 5
MST4 95 8
JNK3 95 5
IR 96 6
ERK1 96 13
SRPK1 97 2
HIPK2 97 9
CHK2 97 9
MNK1 98 6
Src 98 1
CAMKK beta 98 12
SGK1 98 3
CHK1 98 7
JNK1 98 4
PIM2 98 5
p38 gamma MAPK 99 9
PDK1 99 4
CK2 100 3
DYRK2 100 4
DYRK3 100 11
PKB beta 100 4
SYK 100 10
YES1 100 6
AMPK 101 3
MARK3 101 0
TBK1 101 2
MKK1 103 4
PKC alpha 103 5
ROCK 2 104 1
PIM1 104 0
EPH-A2 105 14
SmMLCK 106 4
EF2K 107 3
IKK epsilon 107 1
NEK7 107 8
PKB alpha 110 5
EPH-B3 118 13
MNK2 121 4
FGF-R1 131 54

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