Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
BI-D-1870 C19H23N5O2F2 391.42 RSK Sapkota G.P. (2007) Biochem. J. 401 29–38 WO2003020722 Axon Download

Results as Barchart

View results as a bar chart
0.01µM
0.1µM
10µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 48 1
MKK2 25 9
MKK6 80 1
ERK1 42 1
ERK2 73 0
JNK1 83 8
JNK2 71 4
JNK3 71 1
p38 alpha MAPK 76 11
p38 beta MAPK 90 9
p38 gamma MAPK 89 4
p38 delta MAPK 88 9
ERK8 54 8
RSK1 2 0
RSK2 1 0
PDK1 78 6
PKB alpha 94 8
PKB beta 95 7
SGK1 67 11
S6K1 54 1
PKA 65 5
ROCK 2 69 3
PRK2 67 6
PKC alpha 36 6
PKC gamma 44 4
PKC zeta 86 6
PKD1 53 5
STK33 20 1
MSK1 70 7
MNK1 76 0
MNK2 86 4
MAPKAP-K2 89 8
MAPKAP-K3 92 3
PRAK 73 4
CAMKK beta 9 0
CAMK1 60 9
SmMLCK 46 6
PHK 99 4
DAPK1 74 13
CHK1 74 6
CHK2 65 2
GSK3 beta 21 3
CDK2-Cyclin A 30 6
PLK1 2 0
Aurora A 4 0
Aurora B 4 0
LKB1 49 2
AMPK 67 1
MARK1 33 5
MARK2 38 0
MARK3 36 2
MARK4 27 0
BRSK1 43 0
BRSK2 21 1
MELK 3 0
NUAK1 9 0
CK1 delta 32 0
CK2 99 3
DYRK1A 46 6
DYRK2 44 4
DYRK3 29 1
NEK2a 80 0
NEK6 92 0
IKK beta 74 3
IKK epsilon 31 3
TBK1 28 5
PIM1 6 0
PIM2 61 4
PIM3 3 0
SRPK1 80 9
EF2K 96 0
HIPK1 64 1
HIPK2 15 1
HIPK3 72 4
CLK2 11 11
PAK2 74 8
PAK4 12 0
PAK5 29 0
PAK6 35 0
MST2 12 1
MST4 3 0
GCK 8 2
MINK1 8 5
MEKK1 86 6
MLK1 12 6
MLK3 4 0
TAO1 8 2
ASK1 93 3
TAK1 9 2
IRAK4 63 3
RIPK2 73 1
TTK 30 8
MPSK1 69 2
Src 59 3
Lck 34 1
CSK 80 12
YES1 23 6
ABL 40 2
BTK 45 6
JAK2 12 0
SYK 36 5
ZAP70 85 4
TIE2 15 3
BRK 87 5
EPH-A2 52 0
EPH-A4 65 3
EPH-B1 51 2
EPH-B2 48 4
EPH-B3 43 1
EPH-B4 106 8
FGF-R1 13 1
HER4 59 0
IGF-1R 14 3
IR 13 2
IRR 20 1
TrkA 8 2
VEGFR1 3 0
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 98 4
ERK1 114 2
ERK2 84 1
JNK1 88 6
JNK2 115 12
JNK3 96 10
p38 alpha MAPK 87 12
p38 beta MAPK 100 4
p38 gamma MAPK 111 3
p38 delta MAPK 105 8
ERK8 81 6
RSK1 1 0
RSK2 2 5
PDK1 94 7
PKB alpha 97 1
PKB beta 101 14
SGK1 111 7
S6K1 119 8
PKA 88 8
ROCK 2 83 13
PRK2 97 5
PKC alpha 90 9
PKC zeta 80 1
PKD1 62 11
MSK1 124 5
MNK1 87 9
MNK2 96 11
MAPKAP-K2 89 14
MAPKAP-K3 108 12
PRAK 88 14
CAMKK alpha 92 8
CAMKK beta 72 12
CAMK1 103 8
SmMLCK 107 4
PHK 114 13
CHK1 73 0
CHK2 96 2
GSK3 beta 77 5
CDK2-Cyclin A 84 0
PLK1 5 1
Aurora B 22 4
Aurora C 76 4
AMPK 107 6
MARK3 78 5
BRSK2 78 9
MELK 40 5
CK1 delta 81 5
CK2 97 4
DYRK1A 95 9
DYRK2 90 0
DYRK3 90 3
NEK2a 97 10
NEK6 114 8
NEK7 108 0
IKK beta 105 10
IKK epsilon 88 5
TBK1 97 1
PIM1 75 1
PIM2 100 8
PIM3 65 3
SRPK1 94 7
EF2K 87 0
HIPK2 102 6
HIPK3 104 5
PAK4 81 11
PAK5 89 5
PAK6 101 9
MST2 41 3
MST4 77 8
Src 96 3
Lck 85 0
CSK 98 8
YES1 86 0
BTK 96 9
SYK 94 18
EPH-A2 91 3
EPH-B3 109 6
FGF-R1 79 11
IGF-1R 79 3
IR 106 4
IRR 75 5
VEGFR1 59 2
Screening Concentration: 0.01µM
Kinase % Activity Remaining Standard Deviation
MKK1 103 4
ERK1 96 13
ERK2 95 2
JNK1 98 4
JNK2 93 2
JNK3 95 5
p38 alpha MAPK 89 3
p38 beta MAPK 89 0
p38 gamma MAPK 99 9
p38 delta MAPK 89 0
ERK8 94 1
RSK1 14 2
RSK2 32 2
PDK1 99 4
PKB alpha 110 5
PKB beta 100 4
SGK1 98 3
S6K1 83 3
PKA 91 4
ROCK 2 104 1
PRK2 80 5
PKC alpha 103 5
PKC zeta 84 9
PKD1 89 5
MSK1 95 5
MNK1 98 6
MNK2 121 4
MAPKAP-K2 92 6
MAPKAP-K3 57 4
PRAK 84 8
CAMKK beta 98 12
CAMK1 93 5
SmMLCK 106 4
PHK 77 2
CHK1 98 7
CHK2 97 9
GSK3 beta 84 0
CDK2-Cyclin A 88 5
PLK1 33 1
Aurora B 53 5
AMPK 101 3
MARK3 101 0
BRSK2 91 4
MELK 85 1
CK1 delta 93 0
CK2 100 3
DYRK1A 90 3
DYRK2 100 4
DYRK3 100 11
NEK2a 93 4
NEK6 88 4
NEK7 107 8
IKK beta 95 5
IKK epsilon 107 1
TBK1 101 2
PIM1 104 0
PIM2 98 5
PIM3 79 10
SRPK1 97 2
EF2K 107 3
HIPK2 97 9
PAK4 85 3
PAK5 91 5
PAK6 88 0
MST2 65 8
MST4 95 8
Src 98 1
Lck 89 2
CSK 91 1
YES1 100 6
BTK 92 7
SYK 100 10
EPH-A2 105 14
EPH-B3 118 13
FGF-R1 131 54
IGF-1R 71 6
IR 96 6
IRR 79 17
VEGFR1 88 2
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 74 3
MKK2 64 4
MKK6 108 5
ERK1 94 5
ERK2 74 5
JNK1 104 0
JNK2 83 0
JNK3 99 3
p38 alpha MAPK 91 0
p38 beta MAPK 107 4
p38 gamma MAPK 98 11
p38 delta MAPK 93 2
ERK8 39 8
RSK1 0 0
RSK2 4 1
PDK1 84 7
PKB alpha 102 7
PKB beta 103 10
SGK1 83 0
S6K1 41 3
PKA 83 7
ROCK 2 76 0
PRK2 74 2
PKC alpha 96 14
PKC gamma 77 7
PKC zeta 93 0
PKD1 61 0
STK33 62 0
MSK1 73 0
MNK1 90 4
MNK2 95 3
MAPKAP-K2 91 5
MAPKAP-K3 89 1
PRAK 88 6
CAMKK beta 40 7
CAMK1 78 11
SmMLCK 73 6
PHK 108 3
DAPK1 83 2
CHK1 108 11
CHK2 84 5
GSK3 beta 35 3
CDK2-Cyclin A 15 2
PLK1 6 2
Aurora A 24 0
Aurora B 7 1
LKB1 92 3
AMPK 55 2
MARK1 85 2
MARK2 51 4
MARK3 31 5
MARK4 77 7
BRSK1 86 0
BRSK2 76 5
MELK 9 0
NUAK1 44 4
CK1 delta 63 1
CK2 92 1
DYRK1A 60 4
DYRK2 85 1
DYRK3 80 8
NEK2a 59 4
NEK6 98 8
IKK beta 101 4
IKK epsilon 91 0
TBK1 95 10
PIM1 43 1
PIM2 99 12
PIM3 19 0
SRPK1 90 4
EF2K 90 6
HIPK1 90 5
HIPK2 61 1
HIPK3 113 2
CLK2 26 7
PAK2 88 0
PAK4 58 0
PAK5 73 1
PAK6 70 4
MST2 7 0
MST4 25 2
GCK 37 3
MINK1 7 3
MEKK1 108 13
MLK1 16 4
MLK3 8 4
TAO1 18 2
ASK1 102 3
TAK1 49 8
IRAK4 31 5
RIPK2 92 0
TTK 63 2
MPSK1 105 2
Src 72 11
Lck 63 7
CSK 76 0
YES1 82 15
ABL 90 3
BTK 95 7
JAK2 66 3
SYK 87 8
ZAP70 112 8
TIE2 91 4
BRK 95 10
EPH-A2 98 12
EPH-A4 105 5
EPH-B1 86 1
EPH-B2 93 4
EPH-B3 109 4
EPH-B4 94 6
FGF-R1 108 13
HER4 89 4
IGF-1R 57 3
IR 88 0
IRR 43 7
TrkA 60 1
VEGFR1 19 0

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