Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
BI 2536 C28H39N7O3 521.65 PLK1 Steegmaier M. (2007) Current Biology 17 316-322 Axon Download

Results as Barchart

View results as a bar chart
10µM
1µM
0.1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remainingsort ascending Standard Deviation
EPH-B2 140 21
ASK1 120 12
Aurora A 119 11
BRK 118 5
PKC alpha 117 10
FGF-R1 115 2
TLK1 115 1
EPH-B3 114 2
MNK1 112 2
SIK2 111 7
PKC zeta 109 8
ERK8 109 15
YES1 109 7
HIPK1 109 0
SGK1 108 5
PKC gamma 106 4
p38 beta MAPK 106 12
PKB alpha 106 4
S6K1 106 4
HER4 105 8
PIM2 105 11
MSK1 105 1
TTBK1 105 4
p38 gamma MAPK 104 3
DDR2 104 2
PDK1 104 10
MKK2 104 0
CDK2-Cyclin A 103 2
ERK1 103 3
BRSK1 102 10
PIM1 102 4
EPH-B4 102 4
BTK 102 6
PKA 101 3
CSK 101 2
EPH-B1 100 1
WNK1 100 4
p38 delta MAPK 100 15
EF2K 100 2
HIPK3 100 7
RIPK2 99 8
IKK epsilon 99 2
VEGFR1 99 3
CK2 99 4
TESK1 99 7
MKK1 99 13
CHK1 98 9
PIM3 98 2
MAPKAP-K3 98 8
MARK1 98 2
ABL 97 9
TAO1 97 10
PRAK 97 15
AMPK 97 7
TTK 96 3
IRAK1 96 5
PAK4 95 2
ERK2 94 3
PAK6 94 13
p38 alpha MAPK 94 12
MLK1 94 2
HIPK2 94 5
ZAP70 94 0
DYRK3 94 4
JNK1 93 1
JNK2 93 10
MST3 93 15
MPSK1 93 10
MARK2 93 5
TIE2 93 11
MARK3 92 1
IKK beta 92 4
BRSK2 92 2
TrkA 92 16
GCK 92 2
MNK2 92 7
JAK2 92 3
DYRK2 92 6
PAK2 92 8
EPH-A4 91 3
MST2 91 1
PAK5 90 0
JNK3 90 0
GSK3 beta 90 4
MEKK1 90 5
MAPKAP-K2 90 2
PKB beta 90 6
ROCK 2 89 4
CK1 gamma 2 89 3
DYRK1A 89 8
CAMK1 89 3
EPH-A2 88 7
MST4 88 8
Lck 88 6
CK1 delta 88 10
IGF-1R 86 7
MLK3 86 5
NEK6 85 10
PRK2 85 7
IRR 85 7
LKB1 85 2
CDK9-Cyclin T1 84 1
MARK4 83 9
MKK6 83 1
TBK1 82 2
SIK3 82 5
PHK 80 3
TAK1 80 3
IRAK4 79 2
Src 79 5
STK33 78 18
TSSK1 78 3
MINK1 77 1
SRPK1 77 11
NUAK1 75 1
OSR1 73 2
RSK1 73 6
Aurora B 73 1
RSK2 69 4
SYK 63 7
NEK2a 62 1
IR 61 4
DAPK1 60 2
CHK2 58 4
MELK 48 1
PKD1 48 2
EIF2AK3 24 0
SmMLCK 23 0
CLK2 21 1
CAMKK beta 16 4
PLK1 6 1
Screening Concentration: 10µM
Kinase % Activity Remainingsort ascending Standard Deviation
PIM2 128 4
NUAK1 116 10
ERK8 115 6
VEGFR1 114 1
PAK4 113 3
MARK3 106 4
MST2 102 5
GSK3 beta 101 14
p38 gamma MAPK 101 13
MST4 100 5
MNK2 98 11
MLK3 97 5
p38 delta MAPK 96 4
BRSK2 95 6
PAK5 95 7
DYRK3 95 2
CSK 95 7
PRK2 95 4
PKC zeta 95 12
IKK epsilon 94 5
PRAK 93 4
BTK 93 8
ERK2 92 11
PIM1 92 4
MNK1 91 9
PDK1 91 6
TBK1 90 1
p38 alpha MAPK 90 1
ROCK 2 89 3
Aurora B 89 1
AMPK 86 3
PKB beta 85 2
MSK1 85 0
SGK1 84 3
JNK1 84 5
JNK2 84 1
p38 beta MAPK 84 4
LKB1 83 7
PKC alpha 83 2
EPH-B3 82 5
PKB alpha 81 1
FGF-R1 81 5
PKA 81 0
Src 80 1
MLK1 80 16
PAK6 79 5
CK2 78 3
S6K1 77 10
CHK1 77 1
HER4 77 1
IKK beta 76 3
EPH-A2 76 7
CDK2-Cyclin A 75 7
MAPKAP-K2 74 4
ERK1 74 2
PIM3 74 1
DYRK2 73 11
EF2K 73 3
MKK1 72 6
IRR 70 0
YES1 68 7
GCK 67 4
TTK 66 21
SRPK1 66 1
IR 66 1
MINK1 55 3
DYRK1A 54 0
SYK 54 4
CAMK1 47 1
IRAK4 44 3
NEK6 43 3
Lck 39 4
HIPK2 36 1
RSK1 30 4
PHK 29 3
RSK2 27 5
CK1 delta 27 0
CHK2 26 3
IGF-1R 19 2
CAMKK beta 14 1
SmMLCK 14 3
PKD1 10 1
MELK 9 2
PLK1 7 1
NEK2a 4 2
Screening Concentration: 0.1µM
Kinase % Activity Remainingsort ascending Standard Deviation
BRK 124 1
Aurora C 116 3
EPH-A4 115 1
EPH-B3 115 1
PKC alpha 113 5
MNK1 112 2
EPH-B2 110 7
TrkA 110 14
p38 beta MAPK 109 3
BRSK1 109 1
MST3 109 19
YES1 109 0
Lck 108 8
FGF-R1 108 6
PKC gamma 107 8
NEK6 107 1
ERK8 107 2
HER4 107 8
TBK1 106 1
EPH-B4 106 9
JAK2 106 11
IRR 105 5
CHK1 105 12
PKC zeta 104 0
OSR1 104 7
RSK2 104 3
ABL 104 4
HIPK1 104 4
VEGFR1 103 1
PDK1 103 11
PKB alpha 103 4
PIM3 103 12
p38 alpha MAPK 102 6
DYRK1A 102 4
SGK1 101 4
Aurora A 100 2
TLK1 100 1
DDR2 100 2
IRAK1 99 3
p38 gamma MAPK 99 6
p38 delta MAPK 99 1
MAPKAP-K3 99 13
MKK6 99 11
MLK1 99 6
CAMK1 99 6
TIE2 98 4
RIPK2 98 12
PAK6 98 12
WNK1 98 7
PKA 98 7
DYRK2 97 4
STK33 97 9
NUAK1 97 5
PIM2 97 1
PKB beta 97 5
HIPK3 97 9
EPH-A2 96 9
MSK1 96 13
MPSK1 96 9
PRAK 96 4
JNK3 96 2
RSK1 95 1
CDK9-Cyclin T1 95 6
GCK 95 9
MKK1 95 8
TTBK1 95 5
AMPK 95 6
DYRK3 94 9
MEKK1 94 19
S6K1 94 14
ERK2 94 8
LKB1 94 10
JNK2 94 1
PRK2 94 2
MARK2 93 3
MARK4 93 3
PAK5 93 5
BRSK2 93 5
TTK 93 1
MNK2 93 9
Src 93 5
MKK2 93 10
HIPK2 93 3
ASK1 93 8
ZAP70 92 1
IKK beta 92 9
MAPKAP-K2 92 7
SRPK1 92 10
ERK1 92 6
TAO1 92 1
IKK epsilon 91 4
CSK 91 11
TESK1 91 6
MARK1 90 6
CHK2 90 4
NEK2a 90 10
PKD1 90 12
CDK2-Cyclin A 90 2
EF2K 89 8
MLK3 89 6
PHK 89 2
IRAK4 88 5
EPH-B1 88 1
SIK3 88 4
CK2 88 1
DAPK1 88 6
TSSK1 87 5
PAK4 86 1
PAK2 85 4
PIM1 85 10
MINK1 85 2
BTK 85 8
JNK1 85 6
GSK3 beta 84 1
TAK1 83 0
MST4 83 10
SIK2 83 9
ROCK 2 83 3
MARK3 82 1
MST2 81 0
Aurora B 80 11
SYK 80 11
IR 79 6
MELK 78 6
CK1 gamma 2 76 13
CK1 delta 76 3
IGF-1R 73 6
SmMLCK 69 0
CLK2 64 10
EIF2AK3 64 3
CAMKK beta 24 6
PLK1 6 1

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