Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
BI 2536 C28H39N7O3 521.65 PLK1 Steegmaier M. (2007) Current Biology 17 316-322 Axon Download

Results as Barchart

View results as a bar chart
10µM
1µM
0.1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 72 6
ERK1 74 2
ERK2 92 11
JNK1 84 5
JNK2 84 1
p38 alpha MAPK 90 1
p38 beta MAPK 84 4
p38 gamma MAPK 101 13
p38 delta MAPK 96 4
ERK8 115 6
RSK1 30 4
RSK2 27 5
PDK1 91 6
PKB alpha 81 1
PKB beta 85 2
SGK1 84 3
S6K1 77 10
PKA 81 0
ROCK 2 89 3
PRK2 95 4
PKC alpha 83 2
PKC zeta 95 12
PKD1 10 1
MSK1 85 0
MNK1 91 9
MNK2 98 11
MAPKAP-K2 74 4
PRAK 93 4
CAMKK beta 14 1
CAMK1 47 1
SmMLCK 14 3
PHK 29 3
CHK1 77 1
CHK2 26 3
GSK3 beta 101 14
CDK2-Cyclin A 75 7
PLK1 7 1
Aurora B 89 1
LKB1 83 7
AMPK 86 3
MARK3 106 4
BRSK2 95 6
MELK 9 2
NUAK1 116 10
CK1 delta 27 0
CK2 78 3
DYRK1A 54 0
DYRK2 73 11
DYRK3 95 2
NEK2a 4 2
NEK6 43 3
IKK beta 76 3
IKK epsilon 94 5
TBK1 90 1
PIM1 92 4
PIM2 128 4
PIM3 74 1
SRPK1 66 1
EF2K 73 3
HIPK2 36 1
PAK4 113 3
PAK5 95 7
PAK6 79 5
MST2 102 5
MST4 100 5
GCK 67 4
MINK1 55 3
MLK1 80 16
MLK3 97 5
IRAK4 44 3
TTK 66 21
Src 80 1
Lck 39 4
CSK 95 7
YES1 68 7
BTK 93 8
SYK 54 4
EPH-A2 76 7
EPH-B3 82 5
FGF-R1 81 5
HER4 77 1
IGF-1R 19 2
IR 66 1
IRR 70 0
VEGFR1 114 1
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 95 8
MKK2 93 10
MKK6 99 11
ERK1 92 6
ERK2 94 8
JNK1 85 6
JNK2 94 1
JNK3 96 2
p38 alpha MAPK 102 6
p38 beta MAPK 109 3
p38 gamma MAPK 99 6
p38 delta MAPK 99 1
ERK8 107 2
RSK1 95 1
RSK2 104 3
PDK1 103 11
PKB alpha 103 4
PKB beta 97 5
SGK1 101 4
S6K1 94 14
PKA 98 7
ROCK 2 83 3
PRK2 94 2
PKC alpha 113 5
PKC gamma 107 8
PKC zeta 104 0
PKD1 90 12
STK33 97 9
MSK1 96 13
MNK1 112 2
MNK2 93 9
MAPKAP-K2 92 7
MAPKAP-K3 99 13
PRAK 96 4
CAMKK beta 24 6
CAMK1 99 6
SmMLCK 69 0
PHK 89 2
DAPK1 88 6
CHK1 105 12
CHK2 90 4
GSK3 beta 84 1
CDK2-Cyclin A 90 2
CDK9-Cyclin T1 95 6
PLK1 6 1
Aurora A 100 2
Aurora B 80 11
Aurora C 116 3
TLK1 100 1
LKB1 94 10
AMPK 95 6
MARK1 90 6
MARK2 93 3
MARK3 82 1
MARK4 93 3
BRSK1 109 1
BRSK2 93 5
MELK 78 6
NUAK1 97 5
SIK2 83 9
SIK3 88 4
TSSK1 87 5
CK1 gamma 2 76 13
CK1 delta 76 3
CK2 88 1
TTBK1 95 5
DYRK1A 102 4
DYRK2 97 4
DYRK3 94 9
NEK2a 90 10
NEK6 107 1
IKK beta 92 9
IKK epsilon 91 4
TBK1 106 1
PIM1 85 10
PIM2 97 1
PIM3 103 12
SRPK1 92 10
EF2K 89 8
EIF2AK3 64 3
HIPK1 104 4
HIPK2 93 3
HIPK3 97 9
CLK2 64 10
PAK2 85 4
PAK4 86 1
PAK5 93 5
PAK6 98 12
MST2 81 0
MST3 109 19
MST4 83 10
GCK 95 9
MINK1 85 2
MEKK1 94 19
MLK1 99 6
MLK3 89 6
TESK1 91 6
TAO1 92 1
ASK1 93 8
TAK1 83 0
IRAK1 99 3
IRAK4 88 5
RIPK2 98 12
OSR1 104 7
TTK 93 1
MPSK1 96 9
WNK1 98 7
Src 93 5
Lck 108 8
CSK 91 11
YES1 109 0
ABL 104 4
BTK 85 8
JAK2 106 11
SYK 80 11
ZAP70 92 1
TIE2 98 4
BRK 124 1
EPH-A2 96 9
EPH-A4 115 1
EPH-B1 88 1
EPH-B2 110 7
EPH-B3 115 1
EPH-B4 106 9
FGF-R1 108 6
HER4 107 8
IGF-1R 73 6
IR 79 6
IRR 105 5
TrkA 110 14
DDR2 100 2
VEGFR1 103 1
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 99 13
MKK2 104 0
MKK6 83 1
ERK1 103 3
ERK2 94 3
JNK1 93 1
JNK2 93 10
JNK3 90 0
p38 alpha MAPK 94 12
p38 beta MAPK 106 12
p38 gamma MAPK 104 3
p38 delta MAPK 100 15
ERK8 109 15
RSK1 73 6
RSK2 69 4
PDK1 104 10
PKB alpha 106 4
PKB beta 90 6
SGK1 108 5
S6K1 106 4
PKA 101 3
ROCK 2 89 4
PRK2 85 7
PKC alpha 117 10
PKC gamma 106 4
PKC zeta 109 8
PKD1 48 2
STK33 78 18
MSK1 105 1
MNK1 112 2
MNK2 92 7
MAPKAP-K2 90 2
MAPKAP-K3 98 8
PRAK 97 15
CAMKK beta 16 4
CAMK1 89 3
SmMLCK 23 0
PHK 80 3
DAPK1 60 2
CHK1 98 9
CHK2 58 4
GSK3 beta 90 4
CDK2-Cyclin A 103 2
CDK9-Cyclin T1 84 1
PLK1 6 1
Aurora A 119 11
Aurora B 73 1
TLK1 115 1
LKB1 85 2
AMPK 97 7
MARK1 98 2
MARK2 93 5
MARK3 92 1
MARK4 83 9
BRSK1 102 10
BRSK2 92 2
MELK 48 1
NUAK1 75 1
SIK2 111 7
SIK3 82 5
TSSK1 78 3
CK1 gamma 2 89 3
CK1 delta 88 10
CK2 99 4
TTBK1 105 4
DYRK1A 89 8
DYRK2 92 6
DYRK3 94 4
NEK2a 62 1
NEK6 85 10
IKK beta 92 4
IKK epsilon 99 2
TBK1 82 2
PIM1 102 4
PIM2 105 11
PIM3 98 2
SRPK1 77 11
EF2K 100 2
EIF2AK3 24 0
HIPK1 109 0
HIPK2 94 5
HIPK3 100 7
CLK2 21 1
PAK2 92 8
PAK4 95 2
PAK5 90 0
PAK6 94 13
MST2 91 1
MST3 93 15
MST4 88 8
GCK 92 2
MINK1 77 1
MEKK1 90 5
MLK1 94 2
MLK3 86 5
TESK1 99 7
TAO1 97 10
ASK1 120 12
TAK1 80 3
IRAK1 96 5
IRAK4 79 2
RIPK2 99 8
OSR1 73 2
TTK 96 3
MPSK1 93 10
WNK1 100 4
Src 79 5
Lck 88 6
CSK 101 2
YES1 109 7
ABL 97 9
BTK 102 6
JAK2 92 3
SYK 63 7
ZAP70 94 0
TIE2 93 11
BRK 118 5
EPH-A2 88 7
EPH-A4 91 3
EPH-B1 100 1
EPH-B2 140 21
EPH-B3 114 2
EPH-B4 102 4
FGF-R1 115 2
HER4 105 8
IGF-1R 86 7
IR 61 4
IRR 85 7
TrkA 92 16
DDR2 104 2
VEGFR1 99 3

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