COVID-19 CLOSURE

COVID-19 Closure

Due to the current situation with Covid 19 this facility is currently closed and all staff are working from home. Although we will be checking emails regularly, there may be a longer delay than usual in replying.

Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
BI 2536 C28H39N7O3 521.65 PLK1 Steegmaier M. (2007) Current Biology 17 316-322 Axon Download

Results as Barchart

View results as a bar chart
10µM
1µM
0.1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 72 6
ERK1 74 2
ERK2 92 11
JNK1 84 5
JNK2 84 1
p38 alpha MAPK 90 1
p38 beta MAPK 84 4
p38 gamma MAPK 101 13
p38 delta MAPK 96 4
ERK8 115 6
RSK1 30 4
RSK2 27 5
PDK1 91 6
PKB alpha 81 1
PKB beta 85 2
SGK1 84 3
S6K1 77 10
PKA 81 0
ROCK 2 89 3
PRK2 95 4
PKC alpha 83 2
PKC zeta 95 12
PKD1 10 1
MSK1 85 0
MNK1 91 9
MNK2 98 11
MAPKAP-K2 74 4
PRAK 93 4
CAMKK beta 14 1
CAMK1 47 1
SmMLCK 14 3
PHK 29 3
CHK1 77 1
CHK2 26 3
GSK3 beta 101 14
CDK2-Cyclin A 75 7
PLK1 7 1
Aurora B 89 1
LKB1 83 7
AMPK 86 3
MARK3 106 4
BRSK2 95 6
MELK 9 2
NUAK1 116 10
CK1 delta 27 0
CK2 78 3
DYRK1A 54 0
DYRK2 73 11
DYRK3 95 2
NEK2a 4 2
NEK6 43 3
IKK beta 76 3
IKK epsilon 94 5
TBK1 90 1
PIM1 92 4
PIM2 128 4
PIM3 74 1
SRPK1 66 1
EF2K 73 3
HIPK2 36 1
PAK4 113 3
PAK5 95 7
PAK6 79 5
MST2 102 5
MST4 100 5
GCK 67 4
MINK1 55 3
MLK1 80 16
MLK3 97 5
IRAK4 44 3
TTK 66 21
Src 80 1
Lck 39 4
CSK 95 7
YES1 68 7
BTK 93 8
SYK 54 4
EPH-A2 76 7
EPH-B3 82 5
FGF-R1 81 5
HER4 77 1
IGF-1R 19 2
IR 66 1
IRR 70 0
VEGFR1 114 1
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 95 8
MKK2 93 10
MKK6 99 11
ERK1 92 6
ERK2 94 8
JNK1 85 6
JNK2 94 1
JNK3 96 2
p38 alpha MAPK 102 6
p38 beta MAPK 109 3
p38 gamma MAPK 99 6
p38 delta MAPK 99 1
ERK8 107 2
RSK1 95 1
RSK2 104 3
PDK1 103 11
PKB alpha 103 4
PKB beta 97 5
SGK1 101 4
S6K1 94 14
PKA 98 7
ROCK 2 83 3
PRK2 94 2
PKC alpha 113 5
PKC gamma 107 8
PKC zeta 104 0
PKD1 90 12
STK33 97 9
MSK1 96 13
MNK1 112 2
MNK2 93 9
MAPKAP-K2 92 7
MAPKAP-K3 99 13
PRAK 96 4
CAMKK beta 24 6
CAMK1 99 6
SmMLCK 69 0
PHK 89 2
DAPK1 88 6
CHK1 105 12
CHK2 90 4
GSK3 beta 84 1
CDK2-Cyclin A 90 2
CDK9-Cyclin T1 95 6
PLK1 6 1
Aurora A 100 2
Aurora B 80 11
Aurora C 116 3
TLK1 100 1
LKB1 94 10
AMPK 95 6
MARK1 90 6
MARK2 93 3
MARK3 82 1
MARK4 93 3
BRSK1 109 1
BRSK2 93 5
MELK 78 6
NUAK1 97 5
SIK2 83 9
SIK3 88 4
TSSK1 87 5
CK1 gamma 2 76 13
CK1 delta 76 3
CK2 88 1
TTBK1 95 5
DYRK1A 102 4
DYRK2 97 4
DYRK3 94 9
NEK2a 90 10
NEK6 107 1
IKK beta 92 9
IKK epsilon 91 4
TBK1 106 1
PIM1 85 10
PIM2 97 1
PIM3 103 12
SRPK1 92 10
EF2K 89 8
EIF2AK3 64 3
HIPK1 104 4
HIPK2 93 3
HIPK3 97 9
CLK2 64 10
PAK2 85 4
PAK4 86 1
PAK5 93 5
PAK6 98 12
MST2 81 0
MST3 109 19
MST4 83 10
GCK 95 9
MINK1 85 2
MEKK1 94 19
MLK1 99 6
MLK3 89 6
TESK1 91 6
TAO1 92 1
ASK1 93 8
TAK1 83 0
IRAK1 99 3
IRAK4 88 5
RIPK2 98 12
OSR1 104 7
TTK 93 1
MPSK1 96 9
WNK1 98 7
Src 93 5
Lck 108 8
CSK 91 11
YES1 109 0
ABL 104 4
BTK 85 8
JAK2 106 11
SYK 80 11
ZAP70 92 1
TIE2 98 4
BRK 124 1
EPH-A2 96 9
EPH-A4 115 1
EPH-B1 88 1
EPH-B2 110 7
EPH-B3 115 1
EPH-B4 106 9
FGF-R1 108 6
HER4 107 8
IGF-1R 73 6
IR 79 6
IRR 105 5
TrkA 110 14
DDR2 100 2
VEGFR1 103 1
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 99 13
MKK2 104 0
MKK6 83 1
ERK1 103 3
ERK2 94 3
JNK1 93 1
JNK2 93 10
JNK3 90 0
p38 alpha MAPK 94 12
p38 beta MAPK 106 12
p38 gamma MAPK 104 3
p38 delta MAPK 100 15
ERK8 109 15
RSK1 73 6
RSK2 69 4
PDK1 104 10
PKB alpha 106 4
PKB beta 90 6
SGK1 108 5
S6K1 106 4
PKA 101 3
ROCK 2 89 4
PRK2 85 7
PKC alpha 117 10
PKC gamma 106 4
PKC zeta 109 8
PKD1 48 2
STK33 78 18
MSK1 105 1
MNK1 112 2
MNK2 92 7
MAPKAP-K2 90 2
MAPKAP-K3 98 8
PRAK 97 15
CAMKK beta 16 4
CAMK1 89 3
SmMLCK 23 0
PHK 80 3
DAPK1 60 2
CHK1 98 9
CHK2 58 4
GSK3 beta 90 4
CDK2-Cyclin A 103 2
CDK9-Cyclin T1 84 1
PLK1 6 1
Aurora A 119 11
Aurora B 73 1
TLK1 115 1
LKB1 85 2
AMPK 97 7
MARK1 98 2
MARK2 93 5
MARK3 92 1
MARK4 83 9
BRSK1 102 10
BRSK2 92 2
MELK 48 1
NUAK1 75 1
SIK2 111 7
SIK3 82 5
TSSK1 78 3
CK1 gamma 2 89 3
CK1 delta 88 10
CK2 99 4
TTBK1 105 4
DYRK1A 89 8
DYRK2 92 6
DYRK3 94 4
NEK2a 62 1
NEK6 85 10
IKK beta 92 4
IKK epsilon 99 2
TBK1 82 2
PIM1 102 4
PIM2 105 11
PIM3 98 2
SRPK1 77 11
EF2K 100 2
EIF2AK3 24 0
HIPK1 109 0
HIPK2 94 5
HIPK3 100 7
CLK2 21 1
PAK2 92 8
PAK4 95 2
PAK5 90 0
PAK6 94 13
MST2 91 1
MST3 93 15
MST4 88 8
GCK 92 2
MINK1 77 1
MEKK1 90 5
MLK1 94 2
MLK3 86 5
TESK1 99 7
TAO1 97 10
ASK1 120 12
TAK1 80 3
IRAK1 96 5
IRAK4 79 2
RIPK2 99 8
OSR1 73 2
TTK 96 3
MPSK1 93 10
WNK1 100 4
Src 79 5
Lck 88 6
CSK 101 2
YES1 109 7
ABL 97 9
BTK 102 6
JAK2 92 3
SYK 63 7
ZAP70 94 0
TIE2 93 11
BRK 118 5
EPH-A2 88 7
EPH-A4 91 3
EPH-B1 100 1
EPH-B2 140 21
EPH-B3 114 2
EPH-B4 102 4
FGF-R1 115 2
HER4 105 8
IGF-1R 86 7
IR 61 4
IRR 85 7
TrkA 92 16
DDR2 104 2
VEGFR1 99 3

Do you need any help? Please get in touch and we’ll be happy to lend a hand.