Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
BAY-11-7082 C10H9NO2S 207.2 NFKBIA Kamthong P.J. (2001) Biochem. J. 356 Izban K.F. (2000) Hum. Pathol. 31 1482 WO2003072038 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 105 8
ERK1 121 5
ERK2 84 5
JNK1 91 7
JNK2 85 3
JNK3 107 20
p38 alpha MAPK 100 13
p38 beta MAPK 81 15
p38 gamma MAPK 112 9
p38 delta MAPK 95 8
ERK8 110 7
RSK1 98 11
RSK2 79 2
PDK1 91 4
PKB alpha 102 4
PKB beta 86 15
SGK1 88 10
S6K1 100 16
PKA 91 0
ROCK 2 96 7
PRK2 100 0
PKC alpha 95 6
PKC zeta 100 10
PKD1 83 1
MSK1 95 6
MNK1 117 16
MNK2 95 3
MAPKAP-K2 93 7
MAPKAP-K3 89 8
PRAK 98 13
CAMKK beta 102 6
CAMK1 59 13
SmMLCK 104 13
PHK 91 3
DAPK1 107 13
CHK1 113 18
CHK2 99 6
GSK3 beta 93 6
CDK2-Cyclin A 84 4
PLK1 108 1
Aurora A 103 14
Aurora B 82 12
LKB1 93 1
AMPK 94 5
MARK1 104 2
MARK2 80 11
MARK3 90 3
MARK4 95 1
BRSK1 80 11
BRSK2 106 4
MELK 101 6
NUAK1 93 5
CK1 delta 101 3
CK2 103 2
DYRK1A 96 16
DYRK2 96 0
DYRK3 108 3
NEK2a 104 0
NEK6 100 12
IKK beta 101 10
IKK epsilon 103 1
TBK1 94 1
PIM1 104 5
PIM2 103 9
PIM3 74 6
SRPK1 107 6
EF2K 103 13
HIPK1 108 18
HIPK2 97 4
HIPK3 90 3
CLK2 103 1
PAK2 96 15
PAK4 83 10
PAK5 97 7
PAK6 87 4
MST2 90 16
MST4 89 6
GCK 103 1
MINK1 103 3
MEKK1 88 2
MLK1 86 13
MLK3 93 7
TAK1 108 24
IRAK4 95 1
RIPK2 109 1
TTK 107 14
Src 177 4
Lck 108 10
CSK 98 2
YES1 127 34
BTK 81 3
JAK2 99 9
SYK 94 3
EPH-A2 98 6
EPH-A4 106 1
EPH-B2 101 8
EPH-B3 92 1
EPH-B4 125 4
FGF-R1 90 5
HER4 117 11
IGF-1R 77 40
IR 99 7
IRR 99 1
TrkA 124 5
VEGFR1 80 1
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 92 11
MKK2 89 7
MKK6 85 1
ERK1 102 8
ERK2 79 2
JNK1 99 1
JNK2 78 5
JNK3 83 0
p38 alpha MAPK 88 7
p38 beta MAPK 87 4
p38 gamma MAPK 97 6
p38 delta MAPK 93 1
ERK8 101 6
RSK1 86 1
RSK2 8 0
PDK1 90 4
PKB alpha 90 4
PKB beta 8 1
SGK1 99 6
S6K1 84 2
PKA 89 6
ROCK 2 82 7
PRK2 70 5
PKC alpha 75 0
PKC zeta 92 2
PKD1 72 5
MSK1 79 5
MNK1 89 1
MNK2 96 11
MAPKAP-K2 92 0
MAPKAP-K3 75 0
PRAK 76 3
CAMKK beta 99 1
CAMK1 19 2
SmMLCK 85 9
PHK 106 5
DAPK1 73 6
CHK1 79 2
CHK2 86 0
GSK3 beta 101 3
CDK2-Cyclin A 87 8
PLK1 93 5
Aurora A 14 0
Aurora B 101 14
LKB1 75 4
AMPK 76 4
MARK1 100 1
MARK2 70 1
MARK3 95 7
MARK4 58 3
BRSK1 73 6
BRSK2 41 7
MELK 89 13
NUAK1 20 1
CK1 delta 97 6
CK2 104 4
DYRK1A 86 3
DYRK2 78 5
DYRK3 96 3
NEK2a 88 10
NEK6 92 1
IKK beta 87 2
IKK epsilon 35 1
TBK1 75 6
PIM1 71 3
PIM2 83 7
PIM3 82 1
SRPK1 90 2
EF2K 85 4
HIPK1 82 4
HIPK2 96 5
HIPK3 88 7
CLK2 96 6
PAK2 83 5
PAK4 95 10
PAK5 89 8
PAK6 80 7
MST2 51 5
MST4 61 6
GCK 67 6
MINK1 27 4
MEKK1 94 6
MLK1 78 2
MLK3 93 8
TAO1 81 3
ASK1 101 5
TAK1 99 6
IRAK4 92 2
RIPK2 80 0
TTK 86 3
Src 162 6
Lck 107 4
CSK 92 10
YES1 158 14
BTK 58 6
JAK2 84 3
SYK 78 1
EPH-A2 75 7
EPH-A4 95 4
EPH-B1 94 3
EPH-B2 112 4
EPH-B3 97 6
EPH-B4 87 5
FGF-R1 92 11
HER4 68 2
IGF-1R 95 2
IR 105 10
IRR 87 3
TrkA 87 7
VEGFR1 40 9

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