Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Akti 1/2 C34H29N7O 551.6 Akt1, Akt2 Logie L. (2007) Diabetes 2218-27 Barnett S.F. (2005) Biochem. J. 385 399 WO2013147649 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
0.1µM
10µM
100µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort ascending Standard Deviation
DYRK2 118 1
Src 118 1
p38 beta MAPK 113 3
CK1 delta 110 2
CAMKK beta 108 9
TBK1 106 10
CSK 103 15
PHK 101 9
ERK1 99 5
NEK2a 99 3
p38 alpha MAPK 98 13
p38 delta MAPK 98 11
CDK2-Cyclin A 97 13
PKC zeta 96 9
MARK3 95 12
PDK1 94 7
DYRK1A 93 12
p38 gamma MAPK 93 9
MSK1 93 14
PAK6 92 1
AMPK 92 10
BRSK2 92 12
CK2 91 14
ROCK 2 91 1
IKK beta 89 2
PLK1 89 2
PIM2 89 3
YES1 88 8
PKB beta 87 14
PKC alpha 87 8
CHK1 85 2
NEK7 84 10
EPH-A2 84 7
MNK1 84 1
SYK 84 10
SRPK1 84 9
HIPK2 84 3
SGK1 82 3
CHK2 82 7
PKD1 82 14
JNK2 81 12
IRR 81 13
JNK3 80 7
MST4 80 4
MNK2 79 3
PRAK 79 5
MST2 78 2
GSK3 beta 77 9
MKK1 76 10
PKA 76 5
ERK2 75 14
NEK6 75 3
FGF-R1 75 3
DYRK3 74 1
RSK2 74 1
S6K1 71 6
MAPKAP-K3 71 5
JNK1 70 9
ERK8 70 1
PRK2 67 10
RSK1 67 1
IKK epsilon 67 6
MELK 67 0
HIPK3 65 2
Aurora C 65 0
PKB alpha 64 8
Lck 64 6
CAMKK alpha 62 3
PAK5 60 3
Aurora B 60 3
PIM3 59 6
MAPKAP-K2 59 1
PIM1 56 6
PAK4 48 4
EF2K 40 6
SmMLCK 11 4
CAMK1 3 0
Screening Concentration: 1µM
Kinase % Activity Remainingsort ascending Standard Deviation
NEK6 117 8
PKC zeta 113 4
CK2 111 0
MNK1 110 2
IR 109 3
PAK6 109 8
ASK1 109 3
CDK2-Cyclin A 108 14
p38 beta MAPK 108 9
PDK1 108 4
S6K1 106 8
Src 105 9
JNK3 104 9
CAMKK beta 104 1
GSK3 beta 103 1
JAK2 103 2
MARK4 103 3
EPH-A2 103 6
ERK2 103 4
CSK 102 2
PHK 102 11
MKK2 101 3
MKK6 101 11
EPH-A4 101 1
Aurora B 100 10
MNK2 100 2
EPH-B1 100 8
PKA 100 10
EPH-B2 100 8
PLK1 98 4
MARK3 98 5
MEKK1 98 2
SGK1 98 4
CHK1 98 10
p38 gamma MAPK 97 3
RSK1 97 4
CLK2 96 10
IGF-1R 96 0
EPH-B3 96 14
EPH-B4 95 13
HIPK3 95 8
HER4 95 4
PKB alpha 95 4
BRSK2 95 5
CK1 delta 94 0
MSK1 94 4
Aurora A 94 4
IRR 94 3
BRSK1 94 4
IRAK4 93 6
IKK beta 93 8
MARK2 93 3
JNK2 92 11
PAK2 92 8
TTK 92 3
PRAK 92 5
ERK1 92 8
DYRK3 91 11
MAPKAP-K2 91 3
DAPK1 91 4
NEK2a 90 3
Lck 90 4
JNK1 90 2
CHK2 89 11
LKB1 89 0
GCK 89 2
SYK 89 7
MLK3 89 4
DYRK2 88 5
p38 delta MAPK 88 8
MAPKAP-K3 88 2
TBK1 88 4
ERK8 87 4
AMPK 87 6
TAO1 87 4
PKD1 86 7
PIM2 86 1
DYRK1A 84 2
MKK1 84 12
SRPK1 84 7
MST4 83 2
PKC alpha 82 3
p38 alpha MAPK 82 1
SmMLCK 82 13
ROCK 2 82 10
HIPK2 81 4
FGF-R1 80 7
PIM1 80 0
PRK2 79 7
YES1 79 6
MARK1 79 1
MELK 79 2
TAK1 78 8
HIPK1 77 2
TrkA 76 7
IKK epsilon 76 3
BTK 75 2
RSK2 74 1
MLK1 73 0
VEGFR1 71 3
NUAK1 71 0
PAK4 68 9
MST2 66 1
PKB beta 65 7
PAK5 63 1
PIM3 63 1
EF2K 61 6
RIPK2 57 3
MINK1 54 9
CAMK1 44 7
Screening Concentration: 0.1µM
Kinase % Activity Remainingsort ascending Standard Deviation
PAK6 112 8
p38 alpha MAPK 111 5
p38 gamma MAPK 110 7
IKK epsilon 107 7
EF2K 107 11
CK1 delta 106 7
SGK1 106 5
DYRK2 105 3
p38 delta MAPK 104 5
PHK 104 1
MST2 103 0
TBK1 103 11
p38 beta MAPK 103 10
PKB beta 101 6
PKC alpha 101 5
PKC zeta 101 0
PAK4 99 4
HIPK2 98 6
S6K1 98 1
DYRK1A 97 11
Src 97 3
CHK1 97 0
CSK 97 11
PIM3 97 5
AMPK 96 14
ERK1 95 3
JNK2 95 0
EPH-A2 95 6
PIM2 95 6
RSK1 94 4
MNK2 93 11
BRSK2 93 0
PRAK 93 5
NEK2a 92 6
ROCK 2 92 7
CDK2-Cyclin A 92 3
MST4 92 1
PDK1 91 9
IKK beta 91 11
IRR 91 3
CAMK1 90 3
PKA 90 8
PKD1 90 4
FGF-R1 89 8
PAK5 87 7
DYRK3 87 6
SRPK1 87 1
MARK3 86 1
MELK 86 10
SmMLCK 86 7
NEK7 86 0
YES1 86 4
RSK2 85 7
CK2 85 1
PKB alpha 85 3
JNK1 85 0
MAPKAP-K2 84 6
MSK1 84 2
CHK2 83 7
NEK6 83 1
GSK3 beta 83 3
PLK1 83 2
PIM1 83 12
Aurora B 83 5
Aurora C 83 0
SYK 83 2
MNK1 81 0
Lck 81 4
ERK8 80 5
JNK3 79 3
PRK2 78 1
MAPKAP-K3 76 3
MKK1 75 2
HIPK3 72 2
ERK2 71 15
Screening Concentration: 100µM
Kinase % Activity Remainingsort ascending Standard Deviation
DYRK2 106 0
PKC zeta 104 8
IKK epsilon 100 1
TBK1 100 4
DYRK1A 99 5
IKK beta 98 2
PDK1 98 15
AMPK 97 0
PKC alpha 96 3
CDK2-Cyclin A 93 3
CSK 92 0
ROCK 2 92 9
MST4 92 6
MARK3 90 8
p38 delta MAPK 89 3
CHK1 88 5
CK1 delta 88 5
ERK1 87 2
p38 gamma MAPK 87 0
p38 beta MAPK 86 15
CK2 84 7
PLK1 83 2
p38 alpha MAPK 83 2
MST2 83 7
MNK1 82 0
PKD1 81 3
JNK2 80 7
MNK2 77 10
BRSK2 76 9
NEK2a 70 2
Aurora C 70 15
EPH-A2 69 1
IRR 68 1
HIPK3 68 2
SRPK1 67 0
PAK6 66 1
PAK5 63 5
Src 62 5
YES1 61 2
HIPK2 61 1
DYRK3 60 4
PRK2 59 2
PHK 59 2
CHK2 58 3
Aurora B 56 11
FGF-R1 55 0
MAPKAP-K3 52 2
ERK8 51 1
PRAK 51 4
JNK1 48 1
ERK2 45 1
MELK 45 5
NEK6 44 1
SYK 44 2
GSK3 beta 43 9
EF2K 43 1
JNK3 42 1
MSK1 41 1
PKA 39 0
RSK1 36 1
S6K1 34 11
PAK4 33 1
Lck 31 3
PKB beta 26 2
PIM2 23 0
RSK2 22 1
PIM1 17 1
PIM3 16 1
NEK7 15 0
MKK1 14 3
SGK1 14 5
MAPKAP-K2 12 0
CAMK1 8 0
PKB alpha 6 0
SmMLCK -1 0

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