Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Akti 1/2 C34H29N7O 551.6 Akt1, Akt2 Logie L. (2007) Diabetes 2218-27 Barnett S.F. (2005) Biochem. J. 385 399 WO2013147649 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
0.1µM
10µM
100µM
1µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 75 2
ERK1 95 3
ERK2 71 15
JNK1 85 0
JNK2 95 0
JNK3 79 3
p38 alpha MAPK 111 5
p38 beta MAPK 103 10
p38 gamma MAPK 110 7
p38 delta MAPK 104 5
ERK8 80 5
RSK1 94 4
RSK2 85 7
PDK1 91 9
PKB alpha 85 3
PKB beta 101 6
SGK1 106 5
S6K1 98 1
PKA 90 8
ROCK 2 92 7
PRK2 78 1
PKC alpha 101 5
PKC zeta 101 0
PKD1 90 4
MSK1 84 2
MNK1 81 0
MNK2 93 11
MAPKAP-K2 84 6
MAPKAP-K3 76 3
PRAK 93 5
CAMK1 90 3
SmMLCK 86 7
PHK 104 1
CHK1 97 0
CHK2 83 7
GSK3 beta 83 3
CDK2-Cyclin A 92 3
PLK1 83 2
Aurora B 83 5
Aurora C 83 0
AMPK 96 14
MARK3 86 1
BRSK2 93 0
MELK 86 10
CK1 delta 106 7
CK2 85 1
DYRK1A 97 11
DYRK2 105 3
DYRK3 87 6
NEK2a 92 6
NEK6 83 1
NEK7 86 0
IKK beta 91 11
IKK epsilon 107 7
TBK1 103 11
PIM1 83 12
PIM2 95 6
PIM3 97 5
SRPK1 87 1
EF2K 107 11
HIPK2 98 6
HIPK3 72 2
PAK4 99 4
PAK5 87 7
PAK6 112 8
MST2 103 0
MST4 92 1
Src 97 3
Lck 81 4
CSK 97 11
YES1 86 4
SYK 83 2
EPH-A2 95 6
FGF-R1 89 8
IRR 91 3
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 84 12
MKK2 101 3
MKK6 101 11
ERK1 92 8
ERK2 103 4
JNK1 90 2
JNK2 92 11
JNK3 104 9
p38 alpha MAPK 82 1
p38 beta MAPK 108 9
p38 gamma MAPK 97 3
p38 delta MAPK 88 8
ERK8 87 4
RSK1 97 4
RSK2 74 1
PDK1 108 4
PKB alpha 95 4
PKB beta 65 7
SGK1 98 4
S6K1 106 8
PKA 100 10
ROCK 2 82 10
PRK2 79 7
PKC alpha 82 3
PKC zeta 113 4
PKD1 86 7
MSK1 94 4
MNK1 110 2
MNK2 100 2
MAPKAP-K2 91 3
MAPKAP-K3 88 2
PRAK 92 5
CAMKK beta 104 1
CAMK1 44 7
SmMLCK 82 13
PHK 102 11
DAPK1 91 4
CHK1 98 10
CHK2 89 11
GSK3 beta 103 1
CDK2-Cyclin A 108 14
PLK1 98 4
Aurora A 94 4
Aurora B 100 10
LKB1 89 0
AMPK 87 6
MARK1 79 1
MARK2 93 3
MARK3 98 5
MARK4 103 3
BRSK1 94 4
BRSK2 95 5
MELK 79 2
NUAK1 71 0
CK1 delta 94 0
CK2 111 0
DYRK1A 84 2
DYRK2 88 5
DYRK3 91 11
NEK2a 90 3
NEK6 117 8
IKK beta 93 8
IKK epsilon 76 3
TBK1 88 4
PIM1 80 0
PIM2 86 1
PIM3 63 1
SRPK1 84 7
EF2K 61 6
HIPK1 77 2
HIPK2 81 4
HIPK3 95 8
CLK2 96 10
PAK2 92 8
PAK4 68 9
PAK5 63 1
PAK6 109 8
MST2 66 1
MST4 83 2
GCK 89 2
MINK1 54 9
MEKK1 98 2
MLK1 73 0
MLK3 89 4
TAO1 87 4
ASK1 109 3
TAK1 78 8
IRAK4 93 6
RIPK2 57 3
TTK 92 3
Src 105 9
Lck 90 4
CSK 102 2
YES1 79 6
BTK 75 2
JAK2 103 2
SYK 89 7
EPH-A2 103 6
EPH-A4 101 1
EPH-B1 100 8
EPH-B2 100 8
EPH-B3 96 14
EPH-B4 95 13
FGF-R1 80 7
HER4 95 4
IGF-1R 96 0
IR 109 3
IRR 94 3
TrkA 76 7
VEGFR1 71 3
Screening Concentration: 100µM
Kinase % Activity Remaining Standard Deviation
MKK1 14 3
ERK1 87 2
ERK2 45 1
JNK1 48 1
JNK2 80 7
JNK3 42 1
p38 alpha MAPK 83 2
p38 beta MAPK 86 15
p38 gamma MAPK 87 0
p38 delta MAPK 89 3
ERK8 51 1
RSK1 36 1
RSK2 22 1
PDK1 98 15
PKB alpha 6 0
PKB beta 26 2
SGK1 14 5
S6K1 34 11
PKA 39 0
ROCK 2 92 9
PRK2 59 2
PKC alpha 96 3
PKC zeta 104 8
PKD1 81 3
MSK1 41 1
MNK1 82 0
MNK2 77 10
MAPKAP-K2 12 0
MAPKAP-K3 52 2
PRAK 51 4
CAMK1 8 0
SmMLCK -1 0
PHK 59 2
CHK1 88 5
CHK2 58 3
GSK3 beta 43 9
CDK2-Cyclin A 93 3
PLK1 83 2
Aurora B 56 11
Aurora C 70 15
AMPK 97 0
MARK3 90 8
BRSK2 76 9
MELK 45 5
CK1 delta 88 5
CK2 84 7
DYRK1A 99 5
DYRK2 106 0
DYRK3 60 4
NEK2a 70 2
NEK6 44 1
NEK7 15 0
IKK beta 98 2
IKK epsilon 100 1
TBK1 100 4
PIM1 17 1
PIM2 23 0
PIM3 16 1
SRPK1 67 0
EF2K 43 1
HIPK2 61 1
HIPK3 68 2
PAK4 33 1
PAK5 63 5
PAK6 66 1
MST2 83 7
MST4 92 6
Src 62 5
Lck 31 3
CSK 92 0
YES1 61 2
SYK 44 2
EPH-A2 69 1
FGF-R1 55 0
IRR 68 1
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 76 10
ERK1 99 5
ERK2 75 14
JNK1 70 9
JNK2 81 12
JNK3 80 7
p38 alpha MAPK 98 13
p38 beta MAPK 113 3
p38 gamma MAPK 93 9
p38 delta MAPK 98 11
ERK8 70 1
RSK1 67 1
RSK2 74 1
PDK1 94 7
PKB alpha 64 8
PKB beta 87 14
SGK1 82 3
S6K1 71 6
PKA 76 5
ROCK 2 91 1
PRK2 67 10
PKC alpha 87 8
PKC zeta 96 9
PKD1 82 14
MSK1 93 14
MNK1 84 1
MNK2 79 3
MAPKAP-K2 59 1
MAPKAP-K3 71 5
PRAK 79 5
CAMKK alpha 62 3
CAMKK beta 108 9
CAMK1 3 0
SmMLCK 11 4
PHK 101 9
CHK1 85 2
CHK2 82 7
GSK3 beta 77 9
CDK2-Cyclin A 97 13
PLK1 89 2
Aurora B 60 3
Aurora C 65 0
AMPK 92 10
MARK3 95 12
BRSK2 92 12
MELK 67 0
CK1 delta 110 2
CK2 91 14
DYRK1A 93 12
DYRK2 118 1
DYRK3 74 1
NEK2a 99 3
NEK6 75 3
NEK7 84 10
IKK beta 89 2
IKK epsilon 67 6
TBK1 106 10
PIM1 56 6
PIM2 89 3
PIM3 59 6
SRPK1 84 9
EF2K 40 6
HIPK2 84 3
HIPK3 65 2
PAK4 48 4
PAK5 60 3
PAK6 92 1
MST2 78 2
MST4 80 4
Src 118 1
Lck 64 6
CSK 103 15
YES1 88 8
SYK 84 10
EPH-A2 84 7
FGF-R1 75 3
IRR 81 13

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