Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
AG879 (Tyrphostin) C18H24N2OS 316.5 Tyrosine-kinases Konrad R.J. (1996) J. Biol. Chem. 271 24179 Levitzki A. Gazit A. (1995) Science 267 1782 WO2003068927 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
0.1µM
10µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 95 1
ERK1 88 16
ERK2 91 2
JNK1 99 9
JNK2 90 10
p38 alpha MAPK 105 7
p38 beta MAPK 89 6
p38 gamma MAPK 98 7
p38 delta MAPK 93 11
ERK8 96 2
RSK1 99 9
RSK2 67 2
PDK1 100 0
PKB alpha 103 1
PKB beta 84 3
SGK1 124 15
S6K1 92 4
PKA 85 3
ROCK 2 113 10
PRK2 101 30
PKC alpha 101 10
PKC zeta 86 7
PKD1 99 12
MSK1 82 3
MNK1 101 4
MNK2 84 0
MAPKAP-K2 108 11
PRAK 102 2
CAMKK beta 78 22
CAMK1 85 9
SmMLCK 85 20
PHK 93 19
CHK1 86 1
CHK2 109 23
GSK3 beta 95 7
CDK2-Cyclin A 110 1
PLK1 105 9
AMPK 78 0
MARK3 92 6
BRSK2 87 9
MELK 76 1
CK1 delta 95 0
CK2 123 8
DYRK1A 84 1
DYRK2 110 8
DYRK3 98 11
NEK2a 85 17
NEK6 100 24
IKK beta 109 10
IKK epsilon 78 8
TBK1 90 6
PIM1 102 22
PIM2 98 1
PIM3 98 19
SRPK1 86 0
EF2K 105 4
HIPK2 118 15
PAK4 105 11
PAK5 585 715
PAK6 86 1
MST2 113 8
MST4 83 0
Src 95 11
Lck 99 8
CSK 92 15
YES1 111 13
BTK 55 4
SYK 173 70
EPH-A2 94 12
EPH-B3 96 10
FGF-R1 120 17
IGF-1R 98 16
IR 118 7
IRR 88 0
VEGFR1 92 3
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 83 13
ERK1 90 8
ERK2 87 1
JNK1 87 16
JNK2 70 9
p38 alpha MAPK 81 9
p38 beta MAPK 86 8
p38 gamma MAPK 92 3
p38 delta MAPK 86 11
ERK8 37 0
RSK1 79 1
RSK2 61 4
PDK1 96 5
PKB alpha 94 4
PKB beta 15 9
SGK1 107 13
S6K1 64 14
PKA 93 10
ROCK 2 94 0
PRK2 114 16
PKC alpha 78 6
PKC zeta 67 2
PKD1 80 3
MSK1 88 3
MNK1 99 8
MNK2 76 9
MAPKAP-K2 99 2
PRAK 27 2
CAMKK beta 44 12
CAMK1 88 7
SmMLCK 52 5
PHK 28 1
CHK1 92 19
CHK2 96 14
GSK3 beta 39 4
CDK2-Cyclin A 40 0
PLK1 13 2
AMPK 70 2
MARK3 90 7
BRSK2 66 4
MELK 8 4
CK1 delta 92 6
CK2 118 5
DYRK1A 56 3
DYRK2 102 31
DYRK3 60 1
NEK2a 82 18
NEK6 101 16
IKK beta 105 13
IKK epsilon 63 9
TBK1 97 1
PIM1 25 3
PIM2 53 5
PIM3 34 8
SRPK1 61 12
EF2K 90 8
HIPK2 21 2
PAK4 56 2
PAK5 519 649
PAK6 80 1
MST2 54 1
MST4 72 14
Src 67 0
Lck 107 13
CSK 89 6
YES1 85 1
BTK 46 8
SYK 138 2
EPH-A2 113 11
EPH-B3 55 1
FGF-R1 59 0
IGF-1R 86 4
IR 139 52
IRR 45 4
VEGFR1 50 3

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