Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
AG490 C17H14N2O3 294.3 EGFR, JAK Jaleel M. (2004) Biochemistry 43 8247 Eriksen K.W. (2001) Leukemia 15 787 WO2004052359 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
SGK1 18 2
DYRK1A 24 2
PIM3 25 1
MSK1 28 5
DYRK3 44 5
DYRK2 50 5
PKB beta 52 7
MLK1 52 5
CHK2 52 6
PIM1 53 0
Src 56 1
IRR 58 1
NUAK1 58 4
HER4 62 11
Aurora B 64 3
Aurora A 64 3
NEK2a 65 2
MLK3 65 6
MARK3 70 12
YES1 72 4
BRSK2 75 0
TTK 76 1
PRAK 77 4
MARK2 77 3
ROCK 2 78 4
GSK3 beta 78 3
MELK 79 4
MKK1 82 9
p38 alpha MAPK 82 3
ERK8 83 5
ERK1 83 13
HIPK2 83 0
TrkA 85 8
RSK1 85 11
BTK 85 13
BRSK1 85 5
HIPK1 85 1
VEGFR1 86 14
MST4 86 0
SYK 86 9
AMPK 87 9
EPH-B2 87 7
IKK epsilon 88 0
JNK1 88 5
CK1 delta 88 5
PAK2 88 11
IKK beta 89 3
PAK4 89 10
EF2K 91 5
PRK2 91 8
JNK3 91 7
EPH-A2 92 5
SRPK1 92 2
PKD1 92 3
MINK1 93 6
PIM2 93 10
MKK6 93 12
EPH-B1 93 5
FGF-R1 93 4
LKB1 94 11
SmMLCK 94 15
EPH-A4 94 10
DAPK1 94 11
NEK6 95 13
CSK 95 6
MARK1 95 5
p38 beta MAPK 95 0
S6K1 96 4
RIPK2 96 11
Lck 97 2
EPH-B4 97 6
MNK1 98 2
JAK2 98 4
MARK4 98 9
PHK 98 11
PKA 98 11
p38 delta MAPK 99 3
PAK5 99 5
MEKK1 99 6
JNK2 99 6
CK2 99 5
MST2 101 2
MNK2 102 3
GCK 102 7
CLK2 102 5
PDK1 103 6
HIPK3 103 1
IRAK4 103 1
ERK2 105 9
ASK1 105 2
PKC zeta 105 5
PAK6 106 4
CAMK1 106 4
TBK1 107 2
PKC alpha 107 7
RSK2 109 4
CAMKK beta 109 7
MKK2 109 2
CDK2-Cyclin A 111 11
MAPKAP-K2 112 10
IR 115 6
TAK1 116 1
PKB alpha 117 4
EPH-B3 117 15
CHK1 119 15
PLK1 119 4
IGF-1R 119 5
MAPKAP-K3 122 6
TAO1 125 10
p38 gamma MAPK 129 1
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
SGK1 54 4
MSK1 55 2
PIM3 70 6
DYRK2 71 0
PKB beta 71 7
MLK1 72 4
Src 74 3
DYRK1A 74 1
MARK2 75 4
p38 alpha MAPK 75 4
PAK4 76 3
SYK 76 1
Aurora B 77 2
MLK3 77 1
RSK1 78 4
MELK 78 1
NEK2a 79 8
MINK1 79 3
HIPK1 79 6
LKB1 80 3
SmMLCK 80 1
TTK 81 0
TrkA 82 10
MKK1 82 10
ERK1 82 9
EF2K 82 1
VEGFR1 83 15
CHK1 83 10
PRK2 83 3
MST2 84 1
RSK2 84 8
BTK 84 3
TBK1 84 6
PIM1 84 7
ROCK 2 84 9
NUAK1 84 15
TAK1 84 1
CSK 85 0
SRPK1 85 12
DAPK1 85 10
CHK2 85 12
p38 beta MAPK 86 4
MAPKAP-K3 86 9
EPH-B3 86 9
IRAK4 86 4
DYRK3 87 0
PAK6 87 8
MAPKAP-K2 87 7
MKK2 88 9
GSK3 beta 88 6
HER4 88 1
EPH-A2 89 5
S6K1 89 2
JNK1 89 15
PKD1 90 12
PAK5 90 2
MARK4 90 8
MKK6 90 5
TAO1 90 7
CK1 delta 90 5
CLK2 90 13
IRR 91 6
IKK epsilon 91 0
EPH-B1 91 7
PKA 91 1
EPH-B2 91 6
PLK1 92 7
PDK1 92 12
PRAK 92 1
GCK 92 6
JNK2 93 0
AMPK 94 11
BRSK2 94 12
p38 delta MAPK 96 9
MARK1 96 3
IKK beta 97 4
MARK3 97 3
PKC alpha 98 1
Aurora A 99 1
PKB alpha 99 3
EPH-A4 99 5
HIPK3 99 2
PAK2 100 9
BRSK1 100 5
RIPK2 100 4
IGF-1R 101 1
NEK6 101 12
CDK2-Cyclin A 101 8
ERK8 102 6
PHK 102 7
ASK1 102 7
FGF-R1 102 11
MST4 103 2
JAK2 104 6
PIM2 104 13
EPH-B4 104 9
Lck 105 1
IR 106 2
MNK2 106 5
YES1 106 0
CAMKK beta 106 4
ERK2 106 4
HIPK2 106 4
PKC zeta 107 4
JNK3 109 7
MEKK1 111 6
MNK1 112 0
CAMK1 113 5
CK2 114 1
p38 gamma MAPK 116 5

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