Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
AG490 C17H14N2O3 294.3 EGFR, JAK Jaleel M. (2004) Biochemistry 43 8247 Eriksen K.W. (2001) Leukemia 15 787 WO2004052359 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 82 9
MKK2 109 2
MKK6 93 12
ERK1 83 13
ERK2 105 9
JNK1 88 5
JNK2 99 6
JNK3 91 7
p38 alpha MAPK 82 3
p38 beta MAPK 95 0
p38 gamma MAPK 129 1
p38 delta MAPK 99 3
ERK8 83 5
RSK1 85 11
RSK2 109 4
PDK1 103 6
PKB alpha 117 4
PKB beta 52 7
SGK1 18 2
S6K1 96 4
PKA 98 11
ROCK 2 78 4
PRK2 91 8
PKC alpha 107 7
PKC zeta 105 5
PKD1 92 3
MSK1 28 5
MNK1 98 2
MNK2 102 3
MAPKAP-K2 112 10
MAPKAP-K3 122 6
PRAK 77 4
CAMKK beta 109 7
CAMK1 106 4
SmMLCK 94 15
PHK 98 11
DAPK1 94 11
CHK1 119 15
CHK2 52 6
GSK3 beta 78 3
CDK2-Cyclin A 111 11
PLK1 119 4
Aurora A 64 3
Aurora B 64 3
LKB1 94 11
AMPK 87 9
MARK1 95 5
MARK2 77 3
MARK3 70 12
MARK4 98 9
BRSK1 85 5
BRSK2 75 0
MELK 79 4
NUAK1 58 4
CK1 delta 88 5
CK2 99 5
DYRK1A 24 2
DYRK2 50 5
DYRK3 44 5
NEK2a 65 2
NEK6 95 13
IKK beta 89 3
IKK epsilon 88 0
TBK1 107 2
PIM1 53 0
PIM2 93 10
PIM3 25 1
SRPK1 92 2
EF2K 91 5
HIPK1 85 1
HIPK2 83 0
HIPK3 103 1
CLK2 102 5
PAK2 88 11
PAK4 89 10
PAK5 99 5
PAK6 106 4
MST2 101 2
MST4 86 0
GCK 102 7
MINK1 93 6
MEKK1 99 6
MLK1 52 5
MLK3 65 6
TAO1 125 10
ASK1 105 2
TAK1 116 1
IRAK4 103 1
RIPK2 96 11
TTK 76 1
Src 56 1
Lck 97 2
CSK 95 6
YES1 72 4
BTK 85 13
JAK2 98 4
SYK 86 9
EPH-A2 92 5
EPH-A4 94 10
EPH-B1 93 5
EPH-B2 87 7
EPH-B3 117 15
EPH-B4 97 6
FGF-R1 93 4
HER4 62 11
IGF-1R 119 5
IR 115 6
IRR 58 1
TrkA 85 8
VEGFR1 86 14
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 82 10
MKK2 88 9
MKK6 90 5
ERK1 82 9
ERK2 106 4
JNK1 89 15
JNK2 93 0
JNK3 109 7
p38 alpha MAPK 75 4
p38 beta MAPK 86 4
p38 gamma MAPK 116 5
p38 delta MAPK 96 9
ERK8 102 6
RSK1 78 4
RSK2 84 8
PDK1 92 12
PKB alpha 99 3
PKB beta 71 7
SGK1 54 4
S6K1 89 2
PKA 91 1
ROCK 2 84 9
PRK2 83 3
PKC alpha 98 1
PKC zeta 107 4
PKD1 90 12
MSK1 55 2
MNK1 112 0
MNK2 106 5
MAPKAP-K2 87 7
MAPKAP-K3 86 9
PRAK 92 1
CAMKK beta 106 4
CAMK1 113 5
SmMLCK 80 1
PHK 102 7
DAPK1 85 10
CHK1 83 10
CHK2 85 12
GSK3 beta 88 6
CDK2-Cyclin A 101 8
PLK1 92 7
Aurora A 99 1
Aurora B 77 2
LKB1 80 3
AMPK 94 11
MARK1 96 3
MARK2 75 4
MARK3 97 3
MARK4 90 8
BRSK1 100 5
BRSK2 94 12
MELK 78 1
NUAK1 84 15
CK1 delta 90 5
CK2 114 1
DYRK1A 74 1
DYRK2 71 0
DYRK3 87 0
NEK2a 79 8
NEK6 101 12
IKK beta 97 4
IKK epsilon 91 0
TBK1 84 6
PIM1 84 7
PIM2 104 13
PIM3 70 6
SRPK1 85 12
EF2K 82 1
HIPK1 79 6
HIPK2 106 4
HIPK3 99 2
CLK2 90 13
PAK2 100 9
PAK4 76 3
PAK5 90 2
PAK6 87 8
MST2 84 1
MST4 103 2
GCK 92 6
MINK1 79 3
MEKK1 111 6
MLK1 72 4
MLK3 77 1
TAO1 90 7
ASK1 102 7
TAK1 84 1
IRAK4 86 4
RIPK2 100 4
TTK 81 0
Src 74 3
Lck 105 1
CSK 85 0
YES1 106 0
BTK 84 3
JAK2 104 6
SYK 76 1
EPH-A2 89 5
EPH-A4 99 5
EPH-B1 91 7
EPH-B2 91 6
EPH-B3 86 9
EPH-B4 104 9
FGF-R1 102 11
HER4 88 1
IGF-1R 101 1
IR 106 2
IRR 91 6
TrkA 82 10
VEGFR1 83 15

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