Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
A-769662 C20H12N2O3S 360.39 AMPK Activator Cool B. (2006) Cell Metabolism 3 403-416 US7119205 Tocris Download

Results as Barchart

View results as a bar chart
50µM
10µM
100µM

Results as Table

Screening Concentration: 100µM
Kinase % Activity Remainingsort ascending Standard Deviation
ASK1 250 7
RIPK2 139 3
NEK6 137 5
p38 delta MAPK 124 10
CDK2-Cyclin A 121 0
EPH-B1 97 4
PKA 95 10
JNK1 93 8
MNK1 93 5
PDK1 90 2
PKC alpha 90 11
p38 alpha MAPK 90 5
JNK2 88 1
CK1 delta 88 4
CK2 86 5
MNK2 86 1
MKK6 84 10
DAPK1 83 5
p38 gamma MAPK 83 6
PAK6 82 8
CSK 82 10
PKB alpha 78 2
CAMKK beta 78 4
p38 beta MAPK 77 3
ROCK 2 75 5
PHK 73 1
TAK1 72 8
IR 69 9
MARK1 68 6
IGF-1R 65 5
LKB1 65 6
EPH-A4 64 4
EF2K 64 5
Aurora A 64 4
ERK1 63 11
PAK2 63 8
JNK3 62 11
AMPK 62 5
PRK2 59 2
Lck 58 5
EPH-B3 55 4
BRSK1 51 4
IRR 51 6
FGF-R1 50 8
MARK2 49 2
ERK2 49 10
EPH-B4 49 4
SGK1 48 1
TTK 48 1
GSK3 beta 46 6
MARK4 45 4
CHK1 43 3
HIPK3 43 6
SYK 42 10
MSK1 42 7
PAK4 41 2
EPH-A2 40 5
PAK5 39 1
IKK beta 39 3
MARK3 38 4
S6K1 38 1
SRPK1 35 1
HIPK1 35 2
IRAK4 34 3
CHK2 33 3
DYRK2 33 2
JAK2 32 1
CLK2 30 4
MAPKAP-K2 30 4
TBK1 29 2
MKK1 29 3
BRSK2 28 1
PKC zeta 28 6
TrkA 28 4
DYRK1A 26 3
PLK1 25 2
PKD1 24 1
ERK8 24 4
Aurora B 22 2
MELK 21 0
SmMLCK 20 0
MST2 20 0
MKK2 19 0
HIPK2 19 3
NEK2a 19 0
PIM2 18 1
MLK1 18 2
TAO1 18 1
YES1 16 0
PRAK 15 4
GCK 14 2
MST4 14 0
EPH-B2 13 2
RSK2 13 2
RSK1 12 5
IKK epsilon 12 0
PKB beta 11 2
VEGFR1 11 2
NUAK1 10 0
Src 10 1
BTK 10 1
HER4 8 4
MAPKAP-K3 8 3
PIM1 7 1
CAMK1 7 1
MEKK1 7 0
PIM3 7 2
DYRK3 6 1
MINK1 5 0
MLK3 4 1
Screening Concentration: 10µM
Kinase % Activity Remainingsort ascending Standard Deviation
ASK1 140 5
AMPK 135 15
EPH-B1 110 6
CK2 110 5
RIPK2 110 4
FGF-R1 109 11
SRPK1 107 0
DAPK1 107 1
p38 delta MAPK 107 7
SYK 106 0
MNK1 104 2
NEK6 104 6
SGK1 103 1
ERK2 103 8
IR 103 1
MNK2 102 3
CDK2-Cyclin A 100 3
JNK1 99 5
HIPK2 99 6
HIPK3 97 1
p38 alpha MAPK 97 2
YES1 96 7
PHK 96 0
PKC zeta 96 7
p38 gamma MAPK 95 3
PKB alpha 94 0
JNK2 94 1
PKC alpha 94 6
PAK2 94 2
IGF-1R 94 8
PDK1 93 3
EPH-A4 93 1
EPH-B2 93 5
Aurora A 93 7
MARK4 92 6
ROCK 2 91 2
PKA 89 1
EF2K 89 4
p38 beta MAPK 89 2
CK1 delta 88 5
PLK1 88 1
Lck 88 5
IRR 88 5
CAMKK beta 87 5
IKK beta 86 0
LKB1 86 3
MKK6 85 15
PRK2 85 8
JAK2 83 6
ERK1 83 3
TAO1 83 4
TAK1 83 3
EPH-A2 82 7
EPH-B4 82 8
IRAK4 82 4
EPH-B3 81 11
CLK2 81 2
ERK8 81 3
RSK1 80 7
GSK3 beta 80 1
MKK1 79 1
CHK2 79 4
CSK 79 2
MARK3 78 4
S6K1 78 1
MAPKAP-K2 77 1
GCK 76 5
SmMLCK 76 2
BRSK1 76 5
TTK 76 2
JNK3 75 3
DYRK1A 75 3
RSK2 74 4
MST4 74 5
MKK2 74 3
HIPK1 74 7
NEK2a 73 1
PIM2 71 5
IKK epsilon 69 4
CHK1 69 2
MSK1 69 3
PAK6 69 3
TrkA 69 2
CAMK1 68 3
TBK1 67 8
VEGFR1 65 4
MINK1 65 6
MARK2 64 4
BRSK2 64 4
DYRK2 63 0
PKD1 62 6
NUAK1 61 7
MST2 60 10
MARK1 59 3
MLK1 59 4
PAK5 58 2
MAPKAP-K3 57 1
PKB beta 56 5
DYRK3 54 6
Aurora B 53 0
BTK 52 5
PRAK 52 4
PAK4 52 8
MELK 46 1
Src 44 5
MLK3 43 6
HER4 33 7
PIM1 26 2
MEKK1 26 5
PIM3 18 1
Screening Concentration: 50µM
Kinase % Activity Remainingsort ascending Standard Deviation
p38 alpha MAPK 122 12
p38 delta MAPK 116 12
ERK1 102 3
JNK1 102 3
NEK7 102 4
CHK1 98 4
CK2 95 0
FGF-R1 95 11
NEK6 94 8
PAK6 92 11
IRR 90 4
JNK2 89 10
MARK3 87 4
PRK2 85 9
DYRK2 84 0
CDK2-Cyclin A 84 6
p38 beta MAPK 84 4
PDK1 81 0
MNK2 80 4
p38 gamma MAPK 80 6
ERK2 74 2
EF2K 73 3
JNK3 70 4
AMPK 67 3
PKC zeta 67 6
MNK1 66 4
S6K1 66 5
PHK 65 3
Src 65 13
MELK 64 5
EPH-A2 64 6
BRSK2 63 4
PKB alpha 62 1
CK1 delta 60 6
DYRK1A 60 10
PKC alpha 60 0
IKK beta 60 0
HIPK2 58 2
Lck 58 4
MST4 57 3
TBK1 55 4
SGK1 54 1
HIPK3 52 2
NEK2a 52 9
CHK2 52 4
PAK5 50 6
ROCK 2 49 7
MAPKAP-K3 48 1
CAMKK beta 48 9
IKK epsilon 47 1
DYRK3 47 4
CSK 46 1
CAMK1 45 0
SRPK1 42 8
PKA 41 10
SmMLCK 39 12
MSK1 39 4
PAK4 38 0
PKB beta 37 5
ERK8 36 4
MST2 36 0
SYK 36 3
MAPKAP-K2 32 2
Aurora C 30 4
PLK1 28 1
RSK2 27 7
MKK1 27 10
PRAK 25 1
PKD1 25 12
Aurora B 25 2
GSK3 beta 17 4
PIM2 17 0
YES1 13 2
RSK1 9 0
PIM1 5 0
PIM3 5 0

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