Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
A-769662 C20H12N2O3S 360.39 AMPK Activator Cool B. (2006) Cell Metabolism 3 403-416 US7119205 Tocris Download

Results as Barchart

View results as a bar chart
50µM
10µM
100µM

Results as Table

Screening Concentration: 100µM
Kinase % Activity Remainingsort descending Standard Deviation
MLK3 4 1
MINK1 5 0
DYRK3 6 1
PIM1 7 1
CAMK1 7 1
MEKK1 7 0
PIM3 7 2
HER4 8 4
MAPKAP-K3 8 3
NUAK1 10 0
Src 10 1
BTK 10 1
PKB beta 11 2
VEGFR1 11 2
RSK1 12 5
IKK epsilon 12 0
EPH-B2 13 2
RSK2 13 2
GCK 14 2
MST4 14 0
PRAK 15 4
YES1 16 0
PIM2 18 1
MLK1 18 2
TAO1 18 1
MKK2 19 0
HIPK2 19 3
NEK2a 19 0
SmMLCK 20 0
MST2 20 0
MELK 21 0
Aurora B 22 2
PKD1 24 1
ERK8 24 4
PLK1 25 2
DYRK1A 26 3
BRSK2 28 1
PKC zeta 28 6
TrkA 28 4
TBK1 29 2
MKK1 29 3
CLK2 30 4
MAPKAP-K2 30 4
JAK2 32 1
CHK2 33 3
DYRK2 33 2
IRAK4 34 3
SRPK1 35 1
HIPK1 35 2
MARK3 38 4
S6K1 38 1
PAK5 39 1
IKK beta 39 3
EPH-A2 40 5
PAK4 41 2
SYK 42 10
MSK1 42 7
CHK1 43 3
HIPK3 43 6
MARK4 45 4
GSK3 beta 46 6
SGK1 48 1
TTK 48 1
MARK2 49 2
ERK2 49 10
EPH-B4 49 4
FGF-R1 50 8
BRSK1 51 4
IRR 51 6
EPH-B3 55 4
Lck 58 5
PRK2 59 2
JNK3 62 11
AMPK 62 5
ERK1 63 11
PAK2 63 8
EPH-A4 64 4
EF2K 64 5
Aurora A 64 4
IGF-1R 65 5
LKB1 65 6
MARK1 68 6
IR 69 9
TAK1 72 8
PHK 73 1
ROCK 2 75 5
p38 beta MAPK 77 3
PKB alpha 78 2
CAMKK beta 78 4
PAK6 82 8
CSK 82 10
DAPK1 83 5
p38 gamma MAPK 83 6
MKK6 84 10
CK2 86 5
MNK2 86 1
JNK2 88 1
CK1 delta 88 4
PDK1 90 2
PKC alpha 90 11
p38 alpha MAPK 90 5
JNK1 93 8
MNK1 93 5
PKA 95 10
EPH-B1 97 4
CDK2-Cyclin A 121 0
p38 delta MAPK 124 10
NEK6 137 5
RIPK2 139 3
ASK1 250 7
Screening Concentration: 50µM
Kinase % Activity Remainingsort descending Standard Deviation
PIM1 5 0
PIM3 5 0
RSK1 9 0
YES1 13 2
GSK3 beta 17 4
PIM2 17 0
PRAK 25 1
PKD1 25 12
Aurora B 25 2
RSK2 27 7
MKK1 27 10
PLK1 28 1
Aurora C 30 4
MAPKAP-K2 32 2
ERK8 36 4
MST2 36 0
SYK 36 3
PKB beta 37 5
PAK4 38 0
SmMLCK 39 12
MSK1 39 4
PKA 41 10
SRPK1 42 8
CAMK1 45 0
CSK 46 1
IKK epsilon 47 1
DYRK3 47 4
MAPKAP-K3 48 1
CAMKK beta 48 9
ROCK 2 49 7
PAK5 50 6
HIPK3 52 2
NEK2a 52 9
CHK2 52 4
SGK1 54 1
TBK1 55 4
MST4 57 3
HIPK2 58 2
Lck 58 4
CK1 delta 60 6
DYRK1A 60 10
PKC alpha 60 0
IKK beta 60 0
PKB alpha 62 1
BRSK2 63 4
MELK 64 5
EPH-A2 64 6
PHK 65 3
Src 65 13
MNK1 66 4
S6K1 66 5
AMPK 67 3
PKC zeta 67 6
JNK3 70 4
EF2K 73 3
ERK2 74 2
MNK2 80 4
p38 gamma MAPK 80 6
PDK1 81 0
DYRK2 84 0
CDK2-Cyclin A 84 6
p38 beta MAPK 84 4
PRK2 85 9
MARK3 87 4
JNK2 89 10
IRR 90 4
PAK6 92 11
NEK6 94 8
CK2 95 0
FGF-R1 95 11
CHK1 98 4
ERK1 102 3
JNK1 102 3
NEK7 102 4
p38 delta MAPK 116 12
p38 alpha MAPK 122 12
Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
PIM3 18 1
PIM1 26 2
MEKK1 26 5
HER4 33 7
MLK3 43 6
Src 44 5
MELK 46 1
BTK 52 5
PRAK 52 4
PAK4 52 8
Aurora B 53 0
DYRK3 54 6
PKB beta 56 5
MAPKAP-K3 57 1
PAK5 58 2
MARK1 59 3
MLK1 59 4
MST2 60 10
NUAK1 61 7
PKD1 62 6
DYRK2 63 0
MARK2 64 4
BRSK2 64 4
VEGFR1 65 4
MINK1 65 6
TBK1 67 8
CAMK1 68 3
IKK epsilon 69 4
CHK1 69 2
MSK1 69 3
PAK6 69 3
TrkA 69 2
PIM2 71 5
NEK2a 73 1
RSK2 74 4
MST4 74 5
MKK2 74 3
HIPK1 74 7
JNK3 75 3
DYRK1A 75 3
GCK 76 5
SmMLCK 76 2
BRSK1 76 5
TTK 76 2
MAPKAP-K2 77 1
MARK3 78 4
S6K1 78 1
MKK1 79 1
CHK2 79 4
CSK 79 2
RSK1 80 7
GSK3 beta 80 1
EPH-B3 81 11
CLK2 81 2
ERK8 81 3
EPH-A2 82 7
EPH-B4 82 8
IRAK4 82 4
JAK2 83 6
ERK1 83 3
TAO1 83 4
TAK1 83 3
MKK6 85 15
PRK2 85 8
IKK beta 86 0
LKB1 86 3
CAMKK beta 87 5
CK1 delta 88 5
PLK1 88 1
Lck 88 5
IRR 88 5
PKA 89 1
EF2K 89 4
p38 beta MAPK 89 2
ROCK 2 91 2
MARK4 92 6
PDK1 93 3
EPH-A4 93 1
EPH-B2 93 5
Aurora A 93 7
PKB alpha 94 0
JNK2 94 1
PKC alpha 94 6
PAK2 94 2
IGF-1R 94 8
p38 gamma MAPK 95 3
YES1 96 7
PHK 96 0
PKC zeta 96 7
HIPK3 97 1
p38 alpha MAPK 97 2
JNK1 99 5
HIPK2 99 6
CDK2-Cyclin A 100 3
MNK2 102 3
SGK1 103 1
ERK2 103 8
IR 103 1
MNK1 104 2
NEK6 104 6
SYK 106 0
SRPK1 107 0
DAPK1 107 1
p38 delta MAPK 107 7
FGF-R1 109 11
EPH-B1 110 6
CK2 110 5
RIPK2 110 4
AMPK 135 15
ASK1 140 5

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